About: Susceptibility of raccoon dogs for experimental SARS-CoV-2 infection

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Susceptibility of raccoon dogs for experimental SARS-CoV-2 infection
Creator	Müller, Thomas Breithaupt, Angele Beer, Martin Höper, Dirk Hoffmann, Donata Wylezich, Claudia Aebischer, Andrea Freuling, Conrad Dorhoi, Anca Mettenleiter, Thomas Rissmann, Melanie Sehl, Julia Balkema-8 Buschmann, Anne Friedrichs, Virginia Klein, Antonia
source	BioRxiv
abstract	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in China at the end of 2019, and became pandemic. The zoonotic virus most likely originated from bats, but definite intermediate hosts have not yet been identified. Raccoon dogs (Nyctereutes procyonoides) are kept for fur production, in particular in China, and were suspected as potential intermediate host for both SARS-CoV6 and SARS-CoV2. Here we demonstrate susceptibility of raccoon dogs for SARS-CoV-2 infection after intranasal inoculation and transmission to direct contact animals. Rapid, high level virus shedding, in combination with minor clinical signs and pathohistological changes, seroconversion and absence of viral adaptation highlight the role of raccoon dogs as a potential intermediate host. The results are highly relevant for control strategies and emphasize the risk that raccoon dogs may represent a potential SARS-CoV-2 reservoir. Our results support the establishment of adequate surveillance and risk mitigation strategies for kept and wild raccoon dogs. Article Summary Line Raccoon dogs are susceptible to and efficiently transmit SARS-CoV2 and may serve as intermediate host
has issue date	2020-08-20(xsd:dateTime)
bibo:doi	10.1101/2020.08.19.256800
has license	biorxiv
sha1sum (hex)	cf36add27c879d804acc14d4e475745ee5371e2e
schema:url	https://doi.org/10.1101/2020.08.19.256800
resource representing a document's title	Susceptibility of raccoon dogs for experimental SARS-CoV-2 infection
schema:publication	bioRxiv
resource representing a document's body	covid:cf36add27c879d804acc14d4e475745ee5371e2e#body_text
is schema:about of	named entity 'originated' named entity 'suspected' named entity 'Identification' named entity 'SARS-CoV-2' named entity 'RESERVOIR' named entity '2019' named entity 'Raccoon' named entity 'emphasize' named entity 'minor' named entity 'bats' named entity 'raccoon dogs' named entity 'infection' named entity 'clinical signs' named entity 'virus' named entity 'transmission' named entity 'support' named entity 'risk' named entity 'viral' named entity 'Title' named entity 'China' named entity 'infection' named entity 'Raccoon dogs' named entity 'Severe acute respiratory syndrome coronavirus 2' named entity 'Nyctereutes procyonoides' named entity 'SARS-CoV-2' named entity 'intermediate host' named entity 'raccoon dogs' named entity 'raccoon dogs' named entity 'SARS-CoV-2' named entity 'infection' named entity 'inoculum' named entity 'RNA' named entity 'macroscopic' named entity 'ad libitum' named entity 'fruit bats' named entity 'Friedrich-Loeffler-Institut' named entity 'stainless-steel' named entity '28 days' named entity 'raccoon dogs' named entity 'clinical sign' named entity 'Inoculation' named entity 'Germany' named entity 'Langenargen' named entity 'room temperature' named entity 'Germany' named entity 'defecation' named entity 'SARS-CoV-2' named entity 'virus shedding' named entity 'immunoglobulins' named entity 'virus' named entity 'SARS-CoV-2' named entity 'infection' named entity 'oropharyngeal' named entity 'serological' named entity 'raccoon dogs' named entity 'France' named entity 'dynamic increase' named entity 'BSL3' named entity 'SARS-CoV2' named entity 'raccoon dogs' named entity 'raccoon dogs' named entity 'seroconversion' named entity 'SARS-CoV-2' named entity 'RBD' named entity 'Our' named entity 'TCID50' named entity 'inoculation' named entity 'autopsy' named entity 'intermediate host' named entity 'SARS-CoV-2'

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