About: DNA microarrays for the diagnosis of infectious diseases

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	DNA microarrays for the diagnosis of infectious diseases
Creator	Donatin, E Drancourt, M
Source	Elsevier; Medline; PMC
abstract	Abstract The diagnosis of bacterial infections relies on isolation of the bacterium, which is rarely achieved when needed for patient management. Furthermore, culture is poorly suited to the diagnosis of polymicrobial infections. Finally, a syndromic approach should target both bacteria and viruses causing the same syndrome. The detection of specific DNA sequences in clinical specimen, using DNA microarrays, is an alternative. Microarrays were first used as a diagnostic tool in 1993, to identify a hantavirus associated with an outbreak of acute respiratory diseases. The main advantage of microarrays is multiplexing, enabling exploration of the microbiota and pathogen detection in bacteremia, respiratory infections, and digestive infections: circumstance in which DNA arrays may lack sensitivity and provide false negatives. Enrichment of sampling can increase sensitivity. Furthermore, chips allow typing Streptococcus pneumoniae and detecting resistance in Staphylococcus aureus (MRSA) and Mycobacterium tuberculosis (rifampicin, isoniazid, fluoroquinolones). However, the cost and high technical requirements remain a problem for routine use of this bacterial infection diagnostic technology.
has issue date	2012-10-31(xsd:dateTime)
bibo:doi	10.1016/j.medmal.2012.07.017
bibo:pmid	23058632
has license	els-covid
sha1sum (hex)	cee2bf479c55843dbe9e07b1656c9bad01a73da9
schema:url	https://doi.org/10.1016/j.medmal.2012.07.017
resource representing a document's title	DNA microarrays for the diagnosis of infectious diseases
has PubMed Central identifier	PMC7127767
has PubMed identifier	23058632
schema:publication	Médecine et Maladies Infectieuses
resource representing a document's body	covid:cee2bf479c55843dbe9e07b1656c9bad01a73da9#body_text
is schema:about of	named entity 'cost' named entity 'suited' named entity 'provide' named entity 'alternative' named entity 'infections' named entity 'problem' named entity 'infectious diseases' named entity 'POUR' named entity 'ADN' named entity 'ROUTINE' named entity 'RESISTANCE' named entity 'USE OF' named entity 'TECHNOLOGY' named entity 'USING' named entity 'ADVANTAGE' named entity 'USED' named entity 'RESPIRATORY DISEASES' named entity 'REQUIREMENTS' named entity 'FLUOROQUINOLONES' named entity 'DIAGNOSTIC TOOL' named entity 'ENABLING' named entity 'INCREASE' named entity 'RESPIRATORY INFECTIONS' named entity 'FALSE NEGATIVES' named entity 'DNA MICROARRAYS' named entity 'DETECTION' named entity 'CAUSING' named entity 'FOR PATIENT' named entity 'TECHNICAL' named entity 'PROVIDE' named entity 'BACTERIAL INFECTIONS' named entity 'ACUTE' named entity 'DNA SEQUENCES' named entity 'MULTIPLEXING' named entity 'POORLY' named entity 'SAMPLING' named entity 'INFECTIONS' named entity 'PATHOGEN DETECTION' named entity 'TARGET' named entity 'COST' named entity 'ALLOW' named entity 'SYNDROMIC' named entity 'HANTAVIRUS' named entity 'PATIENT MANAGEMENT' named entity 'DNA MICROARRAYS' named entity 'MAIN' named entity 'MICROARRAYS' named entity 'POLYMICROBIAL INFECTIONS' named entity 'STREPTOCOCCUS PNEUMONIAE' named entity 'PROBLEM' named entity 'BACTEREMIA' named entity 'BACTERIA ' named entity 'VIRUSES' named entity 'BACTERIUM' named entity 'SENSITIVITY' named entity 'SYNDROME' named entity 'RARELY' named entity 'OUTBREAK' named entity 'INFECTIOUS DISEASES' named entity 'DIAGNOSTIC' named entity 'DIAGNOSIS' named entity 'GENERAL' named entity 'REVIEW' named entity 'ENRICHMENT' named entity 'MICROBIOTA' named entity 'DETECTING' named entity 'ISONIAZID' named entity 'DIAGNOSTIC' named entity 'ASSOCIATED WITH' named entity 'NEEDED' named entity 'SPECIFIC' named entity 'BACTERIAL INFECTION' named entity 'LACK' named entity 'ALTERNATIVE' named entity 'CHIPS' named entity 'DIAGNOSIS' named entity 'TYPING' named entity 'MYCOBACTERIUM TUBERCULOSIS' named entity 'STAPHYLOCOCCUS AUREUS' named entity 'ISOLATION'

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