About: Clinical characteristics and cytokine profiles of children with acute lower respiratory tract infections caused by human rhinovirus

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Clinical characteristics and cytokine profiles of children with acute lower respiratory tract infections caused by human rhinovirus
Creator	Kim, Dong Ahn, Jong Hwan, Ki
Source	Medline; PMC
abstract	The clinical profile of human rhinovirus (HRV) with regard to lower respiratory infections remains unclear. We analyzed the clinical features and cytokine responses of HRV isolates in children with respiratory infections. Quantitative analysis and genotyping of the HRV-positive samples from 601 nasopharyngeal aspirates (NPAs) were performed using VP4/VP2 sequencing. To compare T-helper1 (Th1) type (IFN-γ, TNF-α) and Th2 type (IL-4, IL-10) cytokine responses between HRV-A, B and C, the levels of the four cytokines were measured. The HRV-positive children had shorter fever duration (P = 0.018), and higher frequencies of chest retraction (P = 0.002) and wheezing (P = 0.022) than did the HRV-negative group. HRV-A was identified in 55 cases (58.5%), HRV-B in 8 (8.5%), and HRV-C in 31 (33.0%). There were no significant differences in the clinical data or NPA cytokines levels between patients with HRV-A and HRV-C infections. HRV is an important pathogen of the lower respiratory tract in young children. HRV-A and HRV-C are the dominant species that cause respiratory difficulty in young children.
has issue date	2018-07-03(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0198624
bibo:pmid	29969445
has license	cc-by
sha1sum (hex)	cede7520b86628ae52ae0412da430f44cd9271ed
schema:url	https://doi.org/10.1371/journal.pone.0198624
resource representing a document's title	Clinical characteristics and cytokine profiles of children with acute lower respiratory tract infections caused by human rhinovirus
has PubMed Central identifier	PMC6029759
has PubMed identifier	29969445
schema:publication	PLoS One
resource representing a document's body	covid:cede7520b86628ae52ae0412da430f44cd9271ed#body_text
is schema:about of	named entity 'isolates' named entity 'frequencies' named entity 'rhinovirus' named entity 'IMPORTANT' named entity 'infections' named entity 'Th1' named entity 'respiratory infections' named entity 'nasopharyngeal' named entity 'respiratory tract' named entity 'levels' named entity 'IFN-γ' named entity 'wheezing' named entity 'HRV' named entity 'aspirates' named entity 'HRV' named entity 'cytokine' named entity 'HRV' named entity 'respiratory infections' named entity 'HRV' named entity 'young children' named entity 'HRV' named entity 'normal range' named entity 'HRV' named entity 'solid organ transplantation' named entity 'epidemiological' named entity 'wheezing' named entity 'correlation' named entity 'HRV' named entity 'HRV' named entity 'HRV' named entity 'genotypes' named entity 'ANOVA' named entity 'white blood cell' named entity 'sequenced' named entity 'HRV' named entity 'RSV' named entity 'PCR' named entity 'HRV' named entity 'lower respiratory tract' named entity 'IFN-γ' named entity 'serotypes' named entity 'Korea' named entity 'Seoul' named entity 'cytokines' named entity 'young children' named entity 'HRV' named entity 'PCR' named entity 'HRV' named entity 'enzyme-linked immunosorbent assay' named entity 'HRV' named entity 'Seoul' named entity 'normal range' named entity 'chronic obstructive pulmonary disease' named entity 'lymphocytes' named entity 'HRV' named entity 'pediatric' named entity 'WBC' named entity 'HRV' named entity 'HRV' named entity 'WBC' named entity 'HRV' named entity 'multiplex PCR' named entity 'viral load' named entity 'HRV' named entity 'croup' named entity 'physical examination' named entity 'nasopharyngeal' named entity 'viral load' named entity 'nucleotide' named entity 'HRV' named entity 'respiratory diseases' named entity 'lower respiratory tract infections' named entity 'TNF-α' named entity 'virus' named entity 'retrospective review' named entity 'Germany' named entity 'respiratory symptom' named entity 'HRV' named entity 'young children'

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