About: Prospects of brassinosteroids in medicinal applications

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Prospects of brassinosteroids in medicinal applications
Creator	Arora, N Bhardwaj, R Kanwar, M Sharma, I Uppal, P
topic	covid:ce988f6980174e7082b45d93fd369d08ef1306be#this
Source	PMC
abstract	Steroids are an imperative group of hormones which play a key role in the transmission of signals that mediate growth and physiological responses in most pluricellular organisms. Brassinosteroids (BRs), a class of plant-specific steroid hormones, control many of the developmental and physiological processes like their animal counterparts, including regulation of gene expression, cell division and expansion, differentiation, programmed cell death, and homeostasis. Recent studies have indicated that these hormones have antiviral, antifungal, antiproliferative, antibacterial, neuroprotective and immunomodulatory properties in animal system. BRs analogues have been reported to have antiviral activity against herpes simplex virus type 1 (HSV-1), arenaviruses as well as against replication of vesicular stomatitis virus (VSV) in Vero cells. Also, antiherpetic activities both in a human conjunctive cell line (IOBA-NHC) and murine herpetic stromal keratitis (HSK) experimental models have been reported. In human cells, anticancer structure-activity relationship of natural BRs revealed their high cytotoxic activity. Since, BRs and their analogues are reported to inhibit cell growth in cancer cell lines, they may be considered as promising phytohormones for potential anticancer drugs. The use of pollens in folk medicine also indicates scope of steroids of plant pollens in medicines. An attempt has been made in this paper to document the information available on the prospects of BRs in therapeutics.
has issue date	2010-10-15(xsd:dateTime)
bibo:doi	10.1007/978-94-007-0189-2_17
has license	no-cc
sha1sum (hex)	ce988f6980174e7082b45d93fd369d08ef1306be
schema:url	https://doi.org/10.1007/978-94-007-0189-2_17
resource representing a document's title	Prospects of brassinosteroids in medicinal applications
has PubMed Central identifier	PMC7120361
schema:publication	Brassinosteroids: A Class of Plant Hormone
resource representing a document's body	covid:ce988f6980174e7082b45d93fd369d08ef1306be#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/ce988f6980174e7082b45d93fd369d08ef1306be
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