About: Embryo vaccination of chickens using a novel adjuvant formulation stimulates protective immunity against Eimeria maxima infection

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About: Embryo vaccination of chickens using a novel adjuvant formulation stimulates protective immunity against Eimeria maxima infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Embryo vaccination of chickens using a novel adjuvant formulation stimulates protective immunity against Eimeria maxima infection
Creator	Dominowski, Paul Hong, Yeong-Ho Lee, Sung-Hyen Min, Wongi Jang, Seung Lillehoj, Hyun Yancey, Robert Lillehoj, Erik
Source	Elsevier; Medline; PMC
abstract	Abstract Our previous study demonstrated that chickens immunized subcutaneously with an Eimeria recombinant profilin protein vaccine emulsified in a Quil A/cholesterol/DDA/Carbopol (QCDC) adjuvant developed partial protection against experimental avian coccidiosis compared with animals immunized with profilin alone. Because in ovo vaccination is presently used in commercial applications worldwide throughout the poultry industry, the current study was undertaken to investigate chicken embryo vaccination with profilin plus QCDC adjuvant. Eighteen day-old embryos were immunized with isotonic saline (control), profilin alone, QCDC alone, or profilin plus QCDC, and orally challenged with live Eimeria maxima at 7 days post-hatch. Body weight gain, fecal oocyst output, and intestinal cytokine transcript levels were assessed as measures of protective immunity. While immunization with profilin alone or QCDC alone did not alter body weight gain of infected chickens compared with the saline control group, vaccination with profilin plus QCDC increased body weight gain such that it was equal to the uninfected controls. Immunization with profilin plus QCDC also reduced fecal oocyst shedding compared with unimmunized controls, although in this case QCDC failed to provide an adjuvant effect since no difference was observed between the profilin-only and profilin/QCDC groups. Finally, increased levels of transcripts encoding IL-1β, IL-15, and IFN-γ were seen in the intestinal tissues of animals given profilin plus QCDC compared with the profilin-only or QCDC-only groups. In summary, this study demonstrates an adjuvant effect of QCDC on body weight gain and intestinal cytokine responses following in ovo vaccination of chickens with an Eimeria profilin vaccine.
has issue date	2010-11-16(xsd:dateTime)
bibo:doi	10.1016/j.vaccine.2010.09.051
bibo:pmid	20956029
has license	els-covid
sha1sum (hex)	ce60e4e83bdbb8e5a0a15d7e6816b7de1a6a0de0
schema:url	https://doi.org/10.1016/j.vaccine.2010.09.051
resource representing a document's title	Embryo vaccination of chickens using a novel adjuvant formulation stimulates protective immunity against Eimeria maxima infection
has PubMed Central identifier	PMC7127098
has PubMed identifier	20956029
schema:publication	Vaccine
resource representing a document's body	covid:ce60e4e83bdbb8e5a0a15d7e6816b7de1a6a0de0#body_text
is schema:about of	named entity 'oocyst' named entity 'chickens' named entity 'embryos' named entity 'gain' named entity 'subcutaneously' named entity 'Immunization' named entity 'responses' named entity 'chickens' named entity 'CURRENT' named entity 'COMPARED' named entity 'PROTECTIVE IMMUNITY' named entity 'EIGHTEEN' named entity 'OUTPUT' named entity 'SEEN' named entity 'ORALLY' named entity 'SALINE' named entity 'FAILED' named entity 'LEVELS' named entity 'PROTEIN ' named entity 'WORLDWIDE' named entity 'EFFECT' named entity 'GIVEN' named entity 'OBSERVED' named entity 'SUMMARY' named entity 'BODY WEIGHT GAIN' named entity 'UNINFECTED' named entity 'OOCYST' named entity 'USED' named entity 'PROTECTIVE IMMUNITY' named entity 'FORMULATION' named entity '90%' named entity 'EMBRYOS' named entity 'TO INVESTIGATE' named entity 'EIMERIA MAXIMA' named entity 'GROUPS' named entity 'ANIMALS' named entity 'DID' named entity 'ISOTONIC SALINE' named entity 'LIVE' named entity 'TISSUES' named entity 'NO DIFFERENCE' named entity 'NOVEL' named entity 'INFECTION' named entity 'EMBRYO' named entity 'VACCINATION' named entity 'USING' named entity 'INCREASED' named entity 'MEASURES' named entity 'FOLLOWING' named entity 'RECOMBINANT' named entity 'ADJUVANT' named entity 'IL-15' named entity 'IMMUNIZED' named entity 'ASSESSED' named entity 'FECAL' named entity 'TO PROVIDE' named entity 'PARTIAL' named entity 'EMBRYO' named entity 'IN OVO' named entity 'POST' named entity 'VACCINATION' named entity 'IFN' named entity 'IMMUNIZATION' named entity 'HATCH' named entity 'INFECTED' named entity 'CYTOKINE ' named entity 'ALTER' named entity 'SHEDDING' named entity 'PREVIOUS' named entity 'PRESENTLY' named entity 'RESPONSES' named entity 'COCCIDIOSIS' named entity 'APPLICATIONS' named entity 'CHICKEN'

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