About: ACE2 expression by colonic epithelial cells is associated with viral infection, immunity and energy metabolism

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About: ACE2 expression by colonic epithelial cells is associated with viral infection, immunity and energy metabolism Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	ACE2 expression by colonic epithelial cells is associated with viral infection, immunity and energy metabolism
Creator	Zhang, Yan Zhao, Jincun Wang, Ping Wang, Jun Huang, Bing Liu, Ming Xu, Yanhui Cui, Jun Luo, Hai-Bin Zhang, Yuxia Bai, Fan Chen, Zhanghua Lew, Andrew Lin, Meng Zhao, Zhiyao Xu, Yiping Zhao, Shanmeizi Zuo, Xiaoyu
Source	MedRxiv
abstract	Respiratory disease caused by the 2019 novel coronavirus (2019-nCoV) pneumonia first emerged in Wuhan, Hubei Province, China, in December 2019 and spread rapidly to other provinces and other countries. Angiotensin-converting enzyme 2 (ACE2) is the receptor for SARS-CoV and has been suggested to be also the receptor for 2019-nCoV. Paradoxically, ACE2 expression in the lung protects mice from SARS-CoV spike protein induced lung injury by attenuating the renin-angiotensin system. In the intestine, ACE2 also suppresses intestinal inflammation by maintaining amino acid homeostasis, antimicrobial peptide expression and ecology of the gut microbiome. Upon analysis of single cell-RNA sequencing data from control subjects and those with colitis or inflammatory bowel disease (IBD), we found that ACE2 expression in the colonocytes was positively associated with genes regulating viral infection, innate and cellular immunity, but was negatively associated with viral transcription, protein translation, humoral immunity, phagocytosis and complement activation. In summary, we suggest that ACE2 may play dual roles in mediating the susceptibility and immunity of 2019-nCoV infection.
has issue date	2020-02-07(xsd:dateTime)
bibo:doi	10.1101/2020.02.05.20020545
has license	medrxiv
sha1sum (hex)	ce5e7eeb8df10f0e4fb08b0dc78730fd2630a90c
schema:url	https://doi.org/10.1101/2020.02.05.20020545
resource representing a document's title	ACE2 expression by colonic epithelial cells is associated with viral infection, immunity and energy metabolism
resource representing a document's body	covid:ce5e7eeb8df10f0e4fb08b0dc78730fd2630a90c#body_text
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