About: Antiviral innate immune response in non-myeloid cells is augmented by chloride ions via an increase in intracellular hypochlorous acid levels

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Antiviral innate immune response in non-myeloid cells is augmented by chloride ions via an increase in intracellular hypochlorous acid levels Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Antiviral innate immune response in non-myeloid cells is augmented by chloride ions via an increase in intracellular hypochlorous acid levels
Creator	Chen, Rui Haas, Jürgen Boote, Toby Cai, Baiyi Ramalingam, Sandeep Twomey, Matthew Wong, Junsheng Fu, Rebecca Griffiths, Samantha Mccaughan, Hugh
topic	covid:ce50fd91c0c1bbd6f3f9de6a231a9cd41700108b#this
Source	Medline; PMC
abstract	Phagocytes destroy ingested microbes by producing hypochlorous acid (HOCl) from chloride ions (Cl(−)) and hydrogen peroxide within phagolysosomes, using the enzyme myeloperoxidase. HOCl, the active ingredient in bleach, has antibacterial/antiviral properties. As myeloperoxidase is needed for HOCl production, non-myeloid cells are considered incapable of producing HOCl. Here, we show that epithelial, fibroblast and hepatic cells have enhanced antiviral activity in the presence of increasing concentrations of sodium chloride (NaCl). Replication of enveloped/non-enveloped, DNA (herpes simplex virus-1, murine gammaherpesvirus 68) and RNA (respiratory syncytial virus, influenza A virus, human coronavirus 229E, coxsackievirus B3) viruses are inhibited in a dose-dependent manner. Whilst treatment with sodium channel inhibitors did not prevent NaCl-mediated virus inhibition, a chloride channel inhibitor reversed inhibition by NaCl, suggesting intracellular chloride is required for antiviral activity. Inhibition is also reversed in the presence of 4-aminobenzoic hydrazide, a myeloperoxidase inhibitor, suggesting epithelial cells have a peroxidase to convert Cl(−) to HOCl. A significant increase in intracellular HOCl production is seen early in infection. These data suggest that non-myeloid cells possess an innate antiviral mechanism dependent on the availability of Cl(−) to produce HOCl. Antiviral activity against a broad range of viral infections can be augmented by increasing availability of NaCl.
has issue date	2018-09-11(xsd:dateTime)
bibo:doi	10.1038/s41598-018-31936-y
bibo:pmid	30206371
has license	cc-by
sha1sum (hex)	ce50fd91c0c1bbd6f3f9de6a231a9cd41700108b
schema:url	https://doi.org/10.1038/s41598-018-31936-y
resource representing a document's title	Antiviral innate immune response in non-myeloid cells is augmented by chloride ions via an increase in intracellular hypochlorous acid levels
has PubMed Central identifier	PMC6134045
has PubMed identifier	30206371
schema:publication	Sci Rep
resource representing a document's body	covid:ce50fd91c0c1bbd6f3f9de6a231a9cd41700108b#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/ce50fd91c0c1bbd6f3f9de6a231a9cd41700108b
is schema:about of	named entity 'CONSIDERED' named entity 'CHLORIDE IONS' named entity 'INHIBITORS' named entity 'CHLORIDE CHANNEL' named entity 'MECHANISM' named entity 'VIRAL INFECTIONS' named entity 'BLEACH' named entity 'RNA' named entity 'SIGNIFICANT' named entity 'INHIBITION' named entity 'ANTIBACTERIAL' named entity 'HYDROGEN PEROXIDE' named entity 'INGESTED' named entity 'TO PRODUCE' named entity 'HAVE' named entity 'TO CONVERT' named entity 'ENHANCED' named entity 'INHIBITED' named entity 'REQUIRED' named entity 'HYPOCHLOROUS ACID' named entity 'DATA' named entity 'INFLUENZA A VIRUS' named entity 'ENZYME' named entity 'USING' named entity 'POSSESS' named entity 'MYELOID CELLS' named entity 'RANGE' named entity 'SUGGEST' named entity 'availability' named entity 'inhibitor' named entity 'presence' named entity 'data' named entity 'chloride channel' named entity 'cells' named entity 'LEVELS' named entity 'PRESENCE OF' named entity 'EPITHELIAL' named entity 'VIRUS' named entity 'INCAPABLE' named entity 'CONCENTRATIONS' named entity 'DNA' named entity 'INCREASE' named entity 'SIMPLEX' named entity 'INTRACELLULAR' named entity 'AUGMENTED' named entity 'PEROXIDASE' named entity 'VIRUSES' named entity 'COXSACKIEVIRUS B3' named entity 'EARLY' named entity 'AVAILABILITY OF' named entity 'NEEDED' named entity 'HYPOCHLOROUS ACID' named entity 'INTRACELLULAR' covid:arg/ce50fd91c0c1bbd6f3f9de6a231a9cd41700108b named entity 'CHLORIDE IONS' named entity 'NON-' named entity 'AUGMENTED' named entity 'MYELOID CELLS' named entity 'PHAGOCYTES' named entity 'REPLICATION' named entity 'REVERSED' named entity 'MYELOPEROXIDASE INHIBITOR' named entity 'HYDRAZIDE' named entity 'EPITHELIAL CELLS' named entity 'FIBROBLAST' named entity 'NON-' named entity 'SYNCYTIAL' named entity 'PREVENT' named entity 'PRODUCTION' named entity 'DOSE-DEPENDENT'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software