About: Incidence, significance, and persistence of human coronavirus infection in hematopoietic stem cell transplant recipients

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About: Incidence, significance, and persistence of human coronavirus infection in hematopoietic stem cell transplant recipients Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Incidence, significance, and persistence of human coronavirus infection in hematopoietic stem cell transplant recipients
Creator	Douglass, Claire Eichenberger, Emily Michael, • Small, Catherine Soave, Rosemary Westblade, Lars Zappetti, Dana Koen Van Besien, • Satlin, J Tsiporah Shore, •
Source	Medline; PMC
abstract	Hematopoietic stem cell transplant (HSCT) recipients are at increased risk of respiratory viral infections and their associated complications. Unlike other respiratory viruses, little is known about the clinical significance of human coronavirus infection (HCoV) in this population. We retrospectively identified all HSCT recipients who were transplanted between May 2013 and June 2017 at our institution and characterized the cumulative incidence of post-transplant HCoV infection. Of 678 patients who underwent HSCT during the study period, 112 (17%) developed HCoV infection, making HCoV the fourth most common respiratory viral infection. Thirty-four (30%) HCoV-infected patients progressed to proven or probable lower respiratory tract infection (LRTI). Age ≥50, graft-versus-host disease, corticosteroids, hypoalbuminemia, and inpatient status at the time of infection were independently associated with progression to LRTI. Twenty-seven (59%) patients who underwent repeat NP swab had persistent viral shedding for ≥21 days, with a median duration of 4 weeks of viral shedding. We conclude that HCoV is common and clinically significant in HSCT recipients, with nearly one-third of patients progressing to proven or probable LRTI. Evaluating for LRTI risk factors found in this study may identify patients who require closer surveillance and aggressive supportive care when infected with HCoV.
has issue date	2018-11-01(xsd:dateTime)
bibo:doi	10.1038/s41409-018-0386-z
bibo:pmid	30385869
has license	no-cc
sha1sum (hex)	ce15555c20f5df43071def9f766f6c724cce1cfb
schema:url	https://doi.org/10.1038/s41409-018-0386-z
resource representing a document's title	Incidence, significance, and persistence of human coronavirus infection in hematopoietic stem cell transplant recipients
has PubMed Central identifier	PMC7091595
has PubMed identifier	30385869
schema:publication	Bone Marrow Transplant
resource representing a document's body	covid:ce15555c20f5df43071def9f766f6c724cce1cfb#body_text
is schema:about of	named entity 'retrospectively' named entity 'study' named entity 'viral infections' named entity 'supportive care' named entity 'hematopoietic stem cell' named entity 'SIGNIFICANCE' named entity 'DAYS' named entity 'POPULATION' named entity 'IDENTIFY' named entity 'INFECTED' named entity 'SURVEILLANCE' named entity 'INFECTION' named entity 'INCREASED RISK' named entity 'CORONAVIRUS INFECTION' named entity 'RISK OF' named entity 'CORTICOSTEROIDS' named entity 'CUMULATIVE INCIDENCE' named entity 'CLINICAL SIGNIFICANCE' named entity 'DURATION' named entity 'ABOUT' named entity 'LITTLE' named entity 'PROBABLE' named entity 'FOURTH' named entity 'PROGRESSING TO' named entity 'INSTITUTION' named entity 'LOWER RESPIRATORY TRACT INFECTION' named entity 'THEIR' named entity 'NEARLY' named entity 'SUPPORTIVE CARE' named entity '4 WEEKS' named entity 'PERSISTENT' named entity 'HSCT' named entity 'RESPIRATORY VIRAL INFECTION' named entity 'TIME' named entity 'IDENTIFIED' named entity 'COMPLICATIONS' named entity 'CONCLUDE' named entity 'RESPIRATORY VIRUSES' named entity 'LRTI' named entity 'CHARACTERIZED' named entity '112' named entity 'ASSOCIATED WITH' named entity 'TRANSPLANT RECIPIENTS' named entity 'EVALUATING' named entity 'HYPOALBUMINEMIA' named entity 'PERIOD' named entity 'MEDIAN' named entity 'PROVEN' named entity 'THIRTY' named entity 'RISK FACTORS' named entity 'GRAFT-VERSUS-HOST DISEASE' named entity 'HEMATOPOIETIC STEM CELL' named entity 'JUNE' named entity 'OUR' named entity 'PERSISTENCE' named entity 'REPEAT' named entity 'PROGRESSED' named entity 'HUMAN CORONAVIRUS' named entity 'HEMATOPOIETIC STEM CELL' named entity 'CORONAVIRUS INFECTION' named entity 'INPATIENT STATUS' named entity 'AGGRESSIVE' named entity 'PROGRESSION' named entity 'ASSOCIATED' named entity 'SIGNIFICANT' named entity 'COMMON' named entity '2859' named entity 'VIRAL INFECTIONS' named entity 'HUMAN CORONAVIRUS' named entity '678' named entity 'STEM CELL TRANSPLANT' named entity 'KNOWN'

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