About: Salt coatings functionalize inert membranes into high-performing filters against infectious respiratory diseases

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About: Salt coatings functionalize inert membranes into high-performing filters against infectious respiratory diseases Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Salt coatings functionalize inert membranes into high-performing filters against infectious respiratory diseases
Creator	Lee, Dong-Hun Quan, Fu-Shi Choi, Hyo-Jick Lee, Su-Hwa Rubino, Ilaria Chu, Ki-Back Armstrong, Sarah Choudhry, Shivanjali Han, Sumin Hornig, Alex Jeon, Byeonghwa Kaleem, Sana Kang, Hae-Ji Kumaran, Surjith Lalani, Romani Oh, Euna Il Kim, Chun
source	Medline; PMC
abstract	Respiratory protection is key in infection prevention of airborne diseases, as highlighted by the COVID-19 pandemic for instance. Conventional technologies have several drawbacks (i.e., cross-infection risk, filtration efficiency improvements limited by difficulty in breathing, and no safe reusability), which have yet to be addressed in a single device. Here, we report the development of a filter overcoming the major technical challenges of respiratory protective devices. Large-pore membranes, offering high breathability but low bacteria capture, were functionalized to have a uniform salt layer on the fibers. The salt-functionalized membranes achieved high filtration efficiency as opposed to the bare membrane, with differences of up to 48%, while maintaining high breathability (> 60% increase compared to commercial surgical masks even for the thickest salt filters tested). The salt-functionalized filters quickly killed Gram-positive and Gram-negative bacteria aerosols in vitro, with CFU reductions observed as early as within 5 min, and in vivo by causing structural damage due to salt recrystallization. The salt coatings retained the pathogen inactivation capability at harsh environmental conditions (37 °C and a relative humidity of 70%, 80% and 90%). Combination of these properties in one filter will lead to the production of an effective device, comprehensibly mitigating infection transmission globally.
has issue date	2020-08-17(xsd:dateTime)
bibo:doi	10.1038/s41598-020-70623-9
bibo:pmid	32807805
has license	cc-by
sha1sum (hex)	ce0001b7025e972ed141f2cce2d3c730b87752c5
schema:url	https://doi.org/10.1038/s41598-020-70623-9
resource representing a document's title	Salt coatings functionalize inert membranes into high-performing filters against infectious respiratory diseases
has PubMed Central identifier	PMC7431535
has PubMed identifier	32807805
schema:publication	Sci Rep
resource representing a document's body	covid:ce0001b7025e972ed141f2cce2d3c730b87752c5#body_text
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