About: Isolation and Identification of a Natural Reassortant Mammalian Orthoreovirus from Least Horseshoe Bat in China

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About: Isolation and Identification of a Natural Reassortant Mammalian Orthoreovirus from Least Horseshoe Bat in China Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Isolation and Identification of a Natural Reassortant Mammalian Orthoreovirus from Least Horseshoe Bat in China
Creator	Wang, Lihua Cao, Lei Cao, Yuxi Feng, Yun Fu, Shihong Lei, Wenwen Liang, Guodong Song, Jingdong Tang, Qing Yang, Weihong Zhang, Hailin
source	Medline; PMC
abstract	BACKGROUND: Mammalian orthoreoviruses (MRVs) have a wide geographic distribution and can infect virtually all mammals. Infections in humans may be either symptomatic or asymptomatic. This study describes the isolation and identification of a natural reassortant MRV from least horseshoe bats (Rhinolophus pusillu) in China, referred to as RpMRV-YN2012. METHODS AND RESULTS: The RpMRV-YN2012 was obtained from urine samples of Rhinolophus pusillus by cell culture. Negative-staining electron microscopy revealed that RpMRV-YN2012 was a non-enveloped icosahedral virus with ∼75 nm in diameter. Polyacrylamide gel electrophoresis (PAGE) migration patterns of the genome segments showed that RpMRV-YN2012 contained 10 segments in a 3:3:4 arrangement. The whole genome sequence of RpMRV2012 was determined. The consensus terminal sequences of all segments of 5’-GCUAh…yUCAUC-3’ (h = A, U or C; y = C or U) were similar to the MRV species within the genus Orthoreovirus. Its evolution and evidence of genetic reassortment were analyzed by sequence comparison and phylogenetic analysis. The results showed that RpMRV-YN2012 is a novel serotype 2 MRV that may have originated from reassortment among bat, human, and/or pig MRV strains which associated with diarrhea, acute gastroenteritis and necrotizing encephalopathy in animals and humans. CONCLUSIONS: RpMRV-YN2012 is a novel bat reassortant MRV, which may have resulted from a reassortment involving MRVs known to infect humans and animals. It is necessary to identify whether RpMRV-YN2012 is associated with diarrhea, acute gastroenteritis and necrotizing encephalopathy in clinical patients. In addition, we should carefully monitor its evolution and virulence in real time.
has issue date	2015-03-17(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0118598
bibo:pmid	25781475
has license	cc-by
sha1sum (hex)	cde537507323b28a413a559c934c435b24546c63
schema:url	https://doi.org/10.1371/journal.pone.0118598
resource representing a document's title	Isolation and Identification of a Natural Reassortant Mammalian Orthoreovirus from Least Horseshoe Bat in China
has PubMed Central identifier	PMC4364601
has PubMed identifier	25781475
schema:publication	PLoS One
resource representing a document's body	covid:cde537507323b28a413a559c934c435b24546c63#body_text
is schema:about of	named entity 'CHINA' named entity 'China' named entity 'Bat' named entity 'IDENTIFICATION' covid:arg/cde537507323b28a413a559c934c435b24546c63 named entity 'ISOLATION' named entity 'STUDY' named entity 'INFECT' named entity 'MAMMALIAN ORTHOREOVIRUSES' named entity 'SYMPTOMATIC' named entity 'INFECTIONS' named entity 'IDENTIFICATION' named entity 'HORSESHOE BAT' named entity 'ISOLATION' named entity 'MAMMALIAN ORTHOREOVIRUS' named entity 'MAMMALS' named entity 'HUMANS' named entity 'CHINA' named entity 'REFERRED TO' named entity 'GEOGRAPHIC DISTRIBUTION' named entity 'NATURAL' named entity 'ASYMPTOMATIC' named entity 'HAVE' named entity 'NATURAL' named entity 'MAY BE' named entity 'EITHER' named entity 'HORSESHOE BATS' named entity 'WIDE' named entity 'natural' named entity 'horseshoe bats' named entity 'Rhinolophus' named entity 'Horseshoe' named entity 'MRVs' named entity 'asymptomatic' named entity 'cytoplasm' named entity 'serotype' named entity 'urine samples' named entity 'protein' named entity 'serotype' named entity 'electron microscopy' named entity 'genome sequences' named entity 'genome sequences' named entity 'Myotis daubentonii' named entity 'SARS' named entity 'diarrhea' named entity 'urine' named entity 'China' named entity 'orthoreovirus' named entity 'viruses' named entity 'urine samples' named entity 'serotype' named entity 'MRVs' named entity 'Yunnan Province' named entity 'phylogenetic trees' named entity 'genome' named entity 'hexamers' named entity 'protein' named entity 'cell culture media' named entity 'phylogenetic trees' named entity '37°C' named entity 'genome' named entity 'Orthoreovirus' named entity 'serotype' named entity 'MRVs' named entity 'primers' named entity 'species group' named entity 'bat' named entity 'MRVs' named entity 'evolution' named entity '37°C' named entity 'amino acid'

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