About: A Membrane Topology Model for Human Interferon Inducible Transmembrane Protein 1

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A Membrane Topology Model for Human Interferon Inducible Transmembrane Protein 1
Creator	Kellam, P Weston, S Czieso, S Smith, S White, I
Source	Medline; PMC
abstract	InterFeron Inducible TransMembrane proteins 1–3 (IFITM1, IFITM2 and IFITM3) are a family of proteins capable of inhibiting the cellular entry of numerous human and animal viruses. IFITM1-3 are unique amongst the currently described viral restriction factors in their apparent ability to block viral entry. This restrictive property is dependant on the localisation of the proteins to plasma and endosomal membranes, which constitute the main portals of viral entry into cells. The topology of the IFITM proteins within cell membranes is an unresolved aspect of their biology. Here we present data from immunofluorescence microscopy, protease cleavage, biotin-labelling and immuno-electron microscopy assays, showing that human IFITM1 has a membrane topology in which the N-terminal domain resides in the cytoplasm, and the C-terminal domain is extracellular. Furthermore, we provide evidence that this topology is conserved for all of the human interferon-induced IFITM proteins. This model is consistent with that recently proposed for murine IFITM3, but differs from that proposed for murine IFITM1.
has issue date	2014-08-08(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0104341
bibo:pmid	25105503
has license	cc-by
sha1sum (hex)	cddbec166688aaf25aa6e2e6dc76a90668ba9e9d
schema:url	https://doi.org/10.1371/journal.pone.0104341
resource representing a document's title	A Membrane Topology Model for Human Interferon Inducible Transmembrane Protein 1
has PubMed Central identifier	PMC4126714
has PubMed identifier	25105503
schema:publication	PLoS One
resource representing a document's body	covid:cddbec166688aaf25aa6e2e6dc76a90668ba9e9d#body_text
is schema:about of	named entity 'proteins' named entity 'plasma' named entity 'localisation' named entity 'protease' named entity 'microscopy' named entity 'ability' named entity 'endosomal' named entity 'MODEL' named entity 'MEMBRANE TOPOLOGY' named entity 'ANIMAL VIRUSES' named entity 'N-TERMINAL ' named entity 'CELL MEMBRANES' named entity 'DOMAIN' named entity 'PROTEINS' named entity 'INTERFERON ' named entity 'PLASMA' named entity 'THEIR' named entity 'DEPENDANT' named entity 'FAMILY' named entity 'ASPECT' named entity 'IMMUNOFLUORESCENCE MICROSCOPY' named entity 'PRESENT' named entity 'MURINE' named entity 'INDUCIBLE' named entity 'LABELLING' named entity 'VIRAL ENTRY' named entity 'CONSISTENT WITH' named entity 'DESCRIBED' named entity 'HUMAN' named entity 'MAIN' named entity 'PROVIDE' named entity 'LOCALISATION' named entity 'TRANSMEMBRANE PROTEINS' named entity 'ENTRY' named entity 'CELLULAR' named entity 'C-TERMINAL' named entity 'PROTEASE CLEAVAGE' named entity 'RECENTLY' named entity 'MODEL' named entity 'BLOCK' named entity 'PROPOSED' named entity 'RESTRICTIVE' named entity 'IFITM3' named entity 'HERE' named entity 'APPARENT' named entity 'UNIQUE' named entity 'INDUCIBLE' named entity 'HUMAN' named entity 'TRANSMEMBRANE PROTEIN 1' named entity 'PORTALS' named entity 'EVIDENCE' named entity 'BUT' named entity 'PROPERTY' named entity 'CAPABLE' named entity 'MEMBRANES' named entity 'CYTOPLASM' named entity 'MEMBRANE TOPOLOGY' named entity 'UNRESOLVED' named entity 'IFITM1' named entity 'EXTRACELLULAR' named entity 'IMMUNO-ELECTRON MICROSCOPY' named entity 'IFITM2' named entity 'TOPOLOGY' named entity 'CELLS' named entity 'INTERFERON ' named entity 'CONSERVED' named entity 'RESTRICTION' named entity 'INHIBITING' named entity 'CURRENTLY' named entity 'VIRAL' named entity 'BIOLOGY' named entity 'DATA' named entity 'BIOTIN' named entity 'NUMEROUS' covid:arg/cddbec166688aaf25aa6e2e6dc76a90668ba9e9d named entity 'murine' named entity 'data'

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