About: Rapid and Long-Term Immunity Elicited by DNA-Encoded Antibody Prophylaxis and DNA Vaccination Against Chikungunya Virus

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Rapid and Long-Term Immunity Elicited by DNA-Encoded Antibody Prophylaxis and DNA Vaccination Against Chikungunya Virus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Rapid and Long-Term Immunity Elicited by DNA-Encoded Antibody Prophylaxis and DNA Vaccination Against Chikungunya Virus
Creator	Khan, Amir Muthumani, Karuppiah Sarangan, Gopalsamy Srikanth, Padma Tingey, Colleen Wise, Megan Chung, Christopher Block, Peter Flingai, Seleeke Muruganantham, Nagarajan Muthumani, Abirami Vijayachari, Paluru Kim, J Reuschel, Emma Sardesai, Niranjan Ugen, Kenneth Weiner, David Chaaithanya, Itta
Source	Medline; PMC
abstract	Background. Vaccination and passive antibody therapies are critical for controlling infectious diseases. Passive antibody administration has limitations, including the necessity for purification and multiple injections for efficacy. Vaccination is associated with a lag phase before generation of immunity. Novel approaches reported here utilize the benefits of both methods for the rapid generation of effective immunity. Methods. A novel antibody-based prophylaxis/therapy entailing the electroporation-mediated delivery of synthetic DNA plasmids encoding biologically active anti–chikungunya virus (CHIKV) envelope monoclonal antibody (dMAb) was designed and evaluated for antiviral efficacy, as well as for the ability to overcome shortcomings inherent with conventional active vaccination and passive immunotherapy. Results. One intramuscular injection of dMAb produced antibodies in vivo more rapidly than active vaccination with an anti-CHIKV DNA vaccine. This dMAb neutralized diverse CHIKV clinical isolates and protected mice from viral challenge. Combination of dMAb and the CHIKV DNA vaccine afforded rapid and long-lived protection. Conclusions. A DNA-based dMAb strategy induced rapid protection against an emerging viral infection. This method can be combined with DNA vaccination as a novel strategy to provide both short- and long-term protection against this emerging infectious disease. These studies have implications for pathogen treatment and control strategies.
has issue date	2016-03-21(xsd:dateTime)
bibo:doi	10.1093/infdis/jiw111
bibo:pmid	27001960
has license	bronze-oa
sha1sum (hex)	cdaf4366490562074139a826e40ee8ffc01071dc
schema:url	https://doi.org/10.1093/infdis/jiw111
resource representing a document's title	Rapid and Long-Term Immunity Elicited by DNA-Encoded Antibody Prophylaxis and DNA Vaccination Against Chikungunya Virus
has PubMed Central identifier	PMC4936642
has PubMed identifier	27001960
schema:publication	Journal of Infectious Diseases
resource representing a document's body	covid:cdaf4366490562074139a826e40ee8ffc01071dc#body_text
is schema:about of	named entity 'RAPID' named entity 'immunity' named entity 'Antibody' named entity 'DNA' named entity 'VACCINATION' named entity 'LAG PHASE' named entity 'EFFICACY' named entity 'BACKGROUND' named entity 'IMMUNITY' named entity 'NOVEL' named entity 'ANTIBODY' named entity 'APPROACHES' named entity 'GENERATION' named entity 'CRITICAL' named entity 'METHODS' named entity 'CONTROLLING' named entity 'LIMITATIONS' named entity 'BENEFITS' named entity 'PASSIVE' named entity 'INJECTIONS' named entity 'ANTIBODY THERAPIES' named entity 'EFFECTIVE' named entity 'MULTIPLE' named entity 'REPORTED' named entity 'DNA VACCINATION' named entity 'RAPID' named entity 'CHIKUNGUNYA VIRUS' named entity 'LONG-TERM' named entity 'ENCODED' named entity 'DNA' named entity 'IMMUNITY' named entity 'PURIFICATION' named entity 'NECESSITY' named entity 'ELICITED BY' named entity 'JOURNAL ' named entity 'ANTIBODY' named entity 'PROPHYLAXIS' named entity 'INFECTIOUS DISEASES' named entity 'INFECTIOUS DISEASES' named entity 'ASSOCIATED WITH' named entity 'INCLUDING' named entity 'ADMINISTRATION' named entity 'HERE' covid:arg/cdaf4366490562074139a826e40ee8ffc01071dc named entity 'controlling' named entity 'antibody' named entity 'Vaccination' named entity 'generation' named entity 'infection' named entity 'IL-6' named entity 'CHIKV' named entity 'Cell nuclei' named entity 'antibody' named entity 'IgG' named entity 'Vero cells' named entity 'mice' named entity 'coding sequences' named entity 'Env' named entity 'mice' named entity 'antibody therapy' named entity 'CHIKV' named entity 'immunoglobulins' named entity 'negative control' named entity 'IgG'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software