About: The great opportunity: Evolutionary applications to medicine and public health

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The great opportunity: Evolutionary applications to medicine and public health
Creator	Nesse, Randolph Stearns, Stephen
Source	Medline; PMC
abstract	Evolutionary biology is an essential basic science for medicine, but few doctors and medical researchers are familiar with its most relevant principles. Most medical schools have geneticists who understand evolution, but few have even one evolutionary biologist to suggest other possible applications. The canyon between evolutionary biology and medicine is wide. The question is whether they offer each other enough to make bridge building worthwhile. What benefits could be expected if evolution were brought fully to bear on the problems of medicine? How would studying medical problems advance evolutionary research? Do doctors need to learn evolution, or is it valuable mainly for researchers? What practical steps will promote the application of evolutionary biology in the areas of medicine where it offers the most? To address these questions, we review current and potential applications of evolutionary biology to medicine and public health. Some evolutionary technologies, such as population genetics, serial transfer production of live vaccines, and phylogenetic analysis, have been widely applied. Other areas, such as infectious disease and aging research, illustrate the dramatic recent progress made possible by evolutionary insights. In still other areas, such as epidemiology, psychiatry, and understanding the regulation of bodily defenses, applying evolutionary principles remains an open opportunity. In addition to the utility of specific applications, an evolutionary perspective fundamentally challenges the prevalent but fundamentally incorrect metaphor of the body as a machine designed by an engineer. Bodies are vulnerable to disease – and remarkably resilient – precisely because they are not machines built from a plan. They are, instead, bundles of compromises shaped by natural selection in small increments to maximize reproduction, not health. Understanding the body as a product of natural selection, not design, offers new research questions and a framework for making medical education more coherent. We conclude with recommendations for actions that would better connect evolutionary biology and medicine in ways that will benefit public health. It is our hope that faculty and students will send this article to their undergraduate and medical school Deans, and that this will initiate discussions about the gap, the great opportunity, and action plans to bring the full power of evolutionary biology to bear on human health problems.
has issue date	2008-02-01(xsd:dateTime)
bibo:doi	10.1111/j.1752-4571.2007.00006.x
bibo:pmid	25567489
has license	no-cc
sha1sum (hex)	cd69df65ac1b519f8032fcc29c7c2506094e0fcf
schema:url	https://doi.org/10.1111/j.1752-4571.2007.00006.x
resource representing a document's title	The great opportunity: Evolutionary applications to medicine and public health
has PubMed Central identifier	PMC3352398
has PubMed identifier	25567489
schema:publication	Evol Appl
resource representing a document's body	covid:cd69df65ac1b519f8032fcc29c7c2506094e0fcf#body_text
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