About: The CC chemokine ligand 2 (CCL2) and CC chemokine receptor 2 (CCR2) are expressed in the heart after infection with Trypanosoma cruzi suggesting that they play an important role in host defense. Infection of CCR2-deficient (CCR2(−/−)) mice with T. cruzi resulted in increased cardiac parasitism, yet the severity of cardiac inflammation was not affected. In addition, expression of interferon-γ and inducible NO synthase in the heart, which are associated with effective killing of trypomastigotes, was not affected in CCR2(−/−) mice. These observations reveal that CCR2 signaling plays a distinct role that is separate from that of influencing either chemotaxis or previously defined anti-trypomastigote mechanisms for the control of T. cruzi’s replication in the heart

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About: The CC chemokine ligand 2 (CCL2) and CC chemokine receptor 2 (CCR2) are expressed in the heart after infection with Trypanosoma cruzi suggesting that they play an important role in host defense. Infection of CCR2-deficient (CCR2(−/−)) mice with T. cruzi resulted in increased cardiac parasitism, yet the severity of cardiac inflammation was not affected. In addition, expression of interferon-γ and inducible NO synthase in the heart, which are associated with effective killing of trypomastigotes, was not affected in CCR2(−/−) mice. These observations reveal that CCR2 signaling plays a distinct role that is separate from that of influencing either chemotaxis or previously defined anti-trypomastigote mechanisms for the control of T. cruzi’s replication in the heart Goto Sponge NotDistinct Permalink

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type	abstract
value	The CC chemokine ligand 2 (CCL2) and CC chemokine receptor 2 (CCR2) are expressed in the heart after infection with Trypanosoma cruzi suggesting that they play an important role in host defense. Infection of CCR2-deficient (CCR2(−/−)) mice with T. cruzi resulted in increased cardiac parasitism, yet the severity of cardiac inflammation was not affected. In addition, expression of interferon-γ and inducible NO synthase in the heart, which are associated with effective killing of trypomastigotes, was not affected in CCR2(−/−) mice. These observations reveal that CCR2 signaling plays a distinct role that is separate from that of influencing either chemotaxis or previously defined anti-trypomastigote mechanisms for the control of T. cruzi’s replication in the heart
subject	Immune system Chemokine receptors Clusters of differentiation EC 1.14.13 Parasitic excavates »more»
part of	Chemokine CC Receptor 2 Is Important for Acute Control of Cardiac Parasitism but Does Not Contribute to Cardiac Inflammation after Infection with Trypanosoma cruzi
is abstract of	Chemokine CC Receptor 2 Is Important for Acute Control of Cardiac Parasitism but Does Not Contribute to Cardiac Inflammation after Infection with Trypanosoma cruzi
is hasSource of	covid:ann/target/6ea0877193dd0f53aec19a019a9334044aba08a4 covid:ann/target/5916af2c2124faa20e2818a03f93c472ab2115e8 covid:ann/target/dd8924860db42fb830eea156fd9d0de462ec7332 covid:ann/target/6c0560a47fe1d6533567e6a40527740552c87fc1 covid:ann/target/7bf97525e6dd3950f538f2aaf7a1151d1aa09e29 »more»

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