About: The DEAD-Box RNA Helicase DDX1 Interacts with the Viral Protein 3D and Inhibits Foot-and-Mouth Disease Virus Replication

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About: The DEAD-Box RNA Helicase DDX1 Interacts with the Viral Protein 3D and Inhibits Foot-and-Mouth Disease Virus Replication Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The DEAD-Box RNA Helicase DDX1 Interacts with the Viral Protein 3D and Inhibits Foot-and-Mouth Disease Virus Replication
Creator	Zheng, Haixue Xue, Qiao Cai, • Liu, • Xue, • Zeng, Qiaoying
Source	Medline; PMC
abstract	Foot-and-mouth disease virus (FMDV) can infect domestic and wild cloven-hoofed animals. The non-structural protein 3D plays an important role in FMDV replication and pathogenesis. However, the interaction partners of 3D, and the effects of those interactions on FMDV replication, remain incompletely elucidated. In the present study, using the yeast two-hybrid system, we identified a porcine cell protein, DEAD-box RNA helicase 1 (DDX1), which interacted with FMDV 3D. The DDX1-3D interaction was further confirmed by co-immunoprecipitation experiments and an indirect immunofluorescence assay (IFA) in porcine kidney 15 (PK-15) cells. DDX1 was reported to either inhibit or facilitate viral replication and regulate host innate immune responses. However, the roles of DDX1 during FMDV infection remain unclear. Our results revealed that DDX1 inhibited FMDV replication in an ATPase/helicase activity-dependent manner. In addition, DDX1 stimulated IFN-β activation in FMDV-infected cells. Together, our results expand the body of knowledge regarding the role of DDX1 in FMDV infection. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s12250-019-00148-7) contains supplementary material, which is available to authorized users.
has issue date	2019-07-29(xsd:dateTime)
bibo:doi	10.1007/s12250-019-00148-7
bibo:pmid	31359346
has license	no-cc
sha1sum (hex)	cd032cf1c7d6bda8be974e6601b7a1e8d79b25de
schema:url	https://doi.org/10.1007/s12250-019-00148-7
resource representing a document's title	The DEAD-Box RNA Helicase DDX1 Interacts with the Viral Protein 3D and Inhibits Foot-and-Mouth Disease Virus Replication
has PubMed Central identifier	PMC6888807
has PubMed identifier	31359346
schema:publication	Virol Sin
resource representing a document's body	covid:cd032cf1c7d6bda8be974e6601b7a1e8d79b25de#body_text
is schema:about of	named entity 'ATPase' named entity 'helicase' named entity 'However' named entity 'remain' named entity 'effects' named entity 'activation' named entity 'Foot-and-Mouth Disease' named entity 'VIRAL REPLICATION' named entity 'PLAYS' named entity 'WILD' named entity 'ACTIVATION' named entity 'INFECTION' named entity 'INTERACTION' named entity 'KNOWLEDGE' named entity 'IDENTIFIED' named entity 'IMPORTANT' named entity 'INFECTED' named entity 'PORCINE' named entity 'IFN' named entity 'CELL' named entity 'DOMESTIC' named entity 'REVEALED' named entity 'ADDITION' named entity 'PATHOGENESIS' named entity 'ANIMALS' named entity 'CO-IMMUNOPRECIPITATION' named entity 'DEPENDENT' named entity 'ROLES' named entity 'STRUCTURAL PROTEIN' named entity 'EFFECTS' named entity 'INTERACTIONS' named entity 'USING' named entity 'ACTIVITY' named entity 'REPLICATION' named entity 'INHIBITED' named entity 'REPORTED' named entity 'RESULTS' named entity 'INDIRECT IMMUNOFLUORESCENCE' named entity 'BODY' named entity 'FMDV' named entity 'NON-' named entity 'HOOFED' named entity 'PARTNERS' named entity 'ATPASE' named entity 'EITHER' named entity 'UNCLEAR' named entity 'INFECT' named entity 'OUR' named entity 'PROTEIN ' named entity 'DEAD-BOX' named entity 'FOOT-AND-MOUTH DISEASE VIRUS' named entity 'ROLE' named entity 'EXPAND' named entity 'DDX1' named entity 'VIRAL PROTEIN' named entity 'RNA HELICASE' named entity 'CONFIRMED BY' named entity 'RNA HELICASE' named entity 'STUDY' named entity 'PROTEIN ' named entity 'REGULATE' named entity 'VIRUS REPLICATION' named entity 'DDX1' named entity 'DEAD-BOX' named entity 'IMMUNE RESPONSES' named entity 'IMMUNOFLUORESCENCE ASSAY' named entity 'STIMULATED' named entity 'HOST' named entity 'PROTEIN' named entity 'CELLS' named entity 'PRESENT' named entity 'FOOT-AND-MOUTH DISEASE VIRUS' named entity 'EXPERIMENTS' named entity 'KIDNEY' named entity 'YEAST TWO-HYBRID SYSTEM' covid:arg/cd032cf1c7d6bda8be974e6601b7a1e8d79b25de

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