About: Cell type-specific immune dysregulation in severely ill COVID-19 patients

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Cell type-specific immune dysregulation in severely ill COVID-19 patients
Creator	Stripp, Barry Chen, Peter Friedman, Oren Zaman, Tanzira Lopez, Andres »more»
topic	covid:cd019197cfacedb65672ee2e17fe63f15d999df6#this
source	MedRxiv; Medline; PMC
abstract	Coronavirus disease 2019 (COVID-19) has quickly become the most serious pandemic since the 1918 flu pandemic. In extreme situations, patients develop a dysregulated inflammatory lung injury called acute respiratory distress syndrome (ARDS) that causes progressive respiratory failure requiring mechanical ventilatory support. Recent studies have demonstrated immunologic dysfunction in severely ill COVID-19 patients. To further delineate the dysregulated immune response driving more severe clinical course from SARS-CoV-2 infection, we used single-cell RNA sequencing (scRNAseq) to analyze the transcriptome of peripheral blood mononuclear cells (PBMC) from hospitalized COVID-19 patients having mild disease (n = 5), developing ARDS (n = 6), and recovering from ARDS (n = 6). Our data demonstrated an overwhelming inflammatory response with select immunodeficiencies within various immune populations in ARDS patients. Specifically, their monocytes had defects in antigen presentation and deficiencies in interferon responsiveness that contrasted the higher interferon signals in lymphocytes. Furthermore, cytotoxic activity was suppressed in both NK and CD8 lymphocytes whereas B cell activation was deficient, which is consistent with the delayed viral clearance in severely ill COVID-19 patients. Finally, we identified altered signaling pathways in the severe group that suggests immunosenescence and immunometabolic changes could be contributing to the dysfunctional immune response. Our study demonstrates that COVID-19 patients with ARDS have an immunologically distinct response when compared to those with a more innocuous disease course and show a state of immune imbalance in which deficiencies in both the innate and adaptive immune response may be contributing to a more severe disease course in COVID-19.
has issue date	2020-07-24(xsd:dateTime)
bibo:doi	10.1101/2020.07.23.20161182
bibo:pmid	32743611
has license	cc-by-nc-nd
sha1sum (hex)	cd019197cfacedb65672ee2e17fe63f15d999df6
schema:url	https://doi.org/10.1101/2020.07.23.20161182
resource representing a document's title	Cell type-specific immune dysregulation in severely ill COVID-19 patients
has PubMed Central identifier	PMC7386732
has PubMed identifier	32743611
schema:publication	medRxiv
resource representing a document's body	covid:cd019197cfacedb65672ee2e17fe63f15d999df6#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/cd019197cfacedb65672ee2e17fe63f15d999df6
is schema:about of	named entity 'patients' named entity 'respiratory failure' named entity 'studies' named entity 'COVID-19' named entity 'monocytes' »more»

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