About: Longitudinal study of age-specific pattern of coronavirus infection in Lyle’s flying fox (Pteropus lylei) in Thailand

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About: Longitudinal study of age-specific pattern of coronavirus infection in Lyle’s flying fox (Pteropus lylei) in Thailand Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Longitudinal study of age-specific pattern of coronavirus infection in Lyle’s flying fox (Pteropus lylei) in Thailand
Creator	Hemachudha, Thiravat Kaewpom, Thongchai Petcharat, Sininat Rodpan, Apaporn Wacharapluesadee, Supaporn Duengkae, Prateep Yingsakmongkon, Sangchai Chaiyes, Aingorn Maneeorn, Pattarapol Phengsakul, Patcharakiti
Source	Medline; PMC
abstract	BACKGROUND: Bats are natural reservoirs for several highly pathogenic and novel viruses including coronaviruses (CoVs) (mainly Alphacoronavirus and Betacoronavirus). Lyle’s flying fox (Pteropus lylei)‘s roosts and foraging sites are usually in the proximity to humans and animals. Knowledge about age-specific pattern of CoV infection in P. lylei, prevalence, and viral shedding at roosts and foraging sites may have an impact on infection-age-structure model to control CoV outbreak. METHODS: P. lylei bats were captured monthly during January–December 2012 for detection of CoV at three areas in Chonburi province; two human dwellings, S1 and S2, where few fruit trees were located with an open pig farm, 0.6 km and 5.5 km away from the bat roost, S3. Nested RT-PCR of RNA-dependent RNA polymerase (RdRp) gene from rectal swabs was used for CoV detection. The strain of CoV was confirmed by sequencing and phylogenetic analysis. RESULTS: CoV infection was found in both juveniles and adult bats between May and October (January, in adults only and April, in juveniles only). Of total rectal swab positives (68/367, 18.5%), ratio was higher in bats captured at S1 (11/44, 25.0%) and S2 (35/99, 35.4%) foraging sites than at roost (S3) (22/224, 9.8%). Juveniles (forearm length ≤ 136 mm) were found with more CoV infection than adults at all three sites; S1 (9/24, 37.5% vs 2/20, 10%), S2 (22/49, 44.9% vs 13/50, 26.0%), and S3 (10/30, 33.3% vs 12/194, 6.2%). The average BCI of CoV infected bats was significantly lower than uninfected bats. No gender difference related to infection was found at the sites. Phylogenetic analysis of conserved RdRp gene revealed that the detected CoVs belonged to group D betacoronavirus (n = 64) and alphacoronavirus (n = 4). CONCLUSIONS: The fact that CoV infection and shedding was found in more juvenile than adult bats may suggest transmission from mother during peripartum period. Whether viral reactivation during parturition period or stress is responsible in maintaining transmission in the bat colony needs to be explored.
has issue date	2018-02-20(xsd:dateTime)
bibo:doi	10.1186/s12985-018-0950-6
bibo:pmid	29463282
has license	cc-by
sha1sum (hex)	ccde33bdca9b5c7f879f105a4596e5b1ad3f9408
schema:url	https://doi.org/10.1186/s12985-018-0950-6
resource representing a document's title	Longitudinal study of age-specific pattern of coronavirus infection in Lyle’s flying fox (Pteropus lylei) in Thailand
has PubMed Central identifier	PMC5819653
has PubMed identifier	29463282
schema:publication	Virol J
resource representing a document's body	covid:ccde33bdca9b5c7f879f105a4596e5b1ad3f9408#body_text
is schema:about of	named entity 'Alphacoronavirus' named entity 'CORONAVIRUS INFECTION' named entity 'INFECTION' named entity 'PATHOGENIC' named entity 'PATTERN' named entity 'PREVALENCE' named entity 'OUTBREAK' named entity 'FLYING FOX' named entity 'BATS' named entity 'AGE-STRUCTURE' named entity 'VIRAL SHEDDING' named entity 'ANIMALS' named entity 'ALPHACORONAVIRUS' named entity 'VIRUSES' named entity 'SPECIFIC' named entity 'TO CONTROL' named entity 'IMPACT' named entity 'USUALLY' named entity 'AGE' named entity 'PROXIMITY' named entity 'FORAGING' named entity 'MAY HAVE' named entity 'NATURAL' named entity 'ABOUT' named entity 'RESERVOIRS' named entity '27S' named entity 'LONGITUDINAL STUDY' named entity 'BETACORONAVIRUS' named entity '27S' named entity 'SPECIFIC' named entity 'FLYING FOX' named entity 'SITES' named entity 'KNOWLEDGE' named entity 'INCLUDING' named entity 'HIGHLY' named entity 'PATTERN' named entity 'NOVEL' named entity 'CORONAVIRUSES' named entity 'HUMANS' named entity 'THAILAND' named entity 'AGE' named entity 'STRUCTURE MODEL' named entity 'BACKGROUND' covid:arg/ccde33bdca9b5c7f879f105a4596e5b1ad3f9408 named entity 'Betacoronavirus' named entity 'natural reservoirs' named entity 'coronaviruses' named entity 'outbreak' named entity 'control' named entity 'roosts' named entity 'Bats' named entity 'foraging' named entity 'Longitudinal study' named entity 'age-structure' named entity 'viral shedding' named entity 'natural reservoirs' named entity 'Pteropus lylei' named entity 'PCR' named entity 'CoV' named entity 'bat' named entity 'infection' named entity 'bat' named entity 'host species' named entity 'virus' named entity 'Philippines' named entity 'Pipistrellus' named entity 'GUI' named entity 'longitudinal study' named entity 'Pteropus rufus' named entity '0.01' named entity 'Reverse Transcription' named entity 'substitution model'

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