About: Detection of central nervous system viral infections in adults in Manado, North Sulawesi, Indonesia

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About: Detection of central nervous system viral infections in adults in Manado, North Sulawesi, Indonesia Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Detection of central nervous system viral infections in adults in Manado, North Sulawesi, Indonesia
Creator	Wiyatno, Ageng Anggreani, Riane Dhenni, Rama Fadhilah, Araniy Feliana, Safari, Dodi Powers, Ann Bernadus, Janno Chairin, Nisa Dewantari, Aghnianditya Jaya, Ungke Ledermann, Jeremy Ma'roef, Mawuntu, Arthur Myintid, Aye Saw, Khin Yudhaputri, Frilasita
source	Medline; PMC
abstract	Central nervous system (CNS) viral infections are important causes of morbidity and mortality worldwide but the systematic survey of patients admitted to hospitals with CNS infections in many countries, including Indonesia, is limited. To obtain more information regarding the causes of CNS infections in Indonesia, this study was performed to detect and identify viral agents associated with CNS infections amongst in-patients at a referral hospital in Manado, North Sulawesi, Indonesia. Adult patients admitted to R.D. Kandou General Hospital with presumed CNS infection were enrolled. Cerebrospinal fluid, serum, and throat swab samples were collected and tested using molecular, serological, and virus isolation assays. A confirmed viral etiology was established in three and a probable/possible in 11 out of 74 patients. The most common was herpes simplex virus 1 (7/74, 9.5%), followed by Epstein-Barr virus (2/74, 2.7%), cytomegalovirus (1/74, 1.4%), enterovirus D68 (1/74, 1.4%), rhinovirus A (1/74, 1.4%), dengue virus (1/64, 1.6%), and Japanese encephalitis virus (1/64, 1.6%). There were 20 fatal cases (27.0%) during hospitalization in which eight were associated with viral causes. We identified herpes simplex virus 1 as the most common cause of CNS infection among adults in North Sulawesi with most of the cases remaining undiagnosed. Our study highlights the challenges in establishing the etiology of viral CNS infections and the importance of using a wide range of molecular and serological detection methods to identify CNS viruses.
has issue date	2018-11-16(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0207440
bibo:pmid	30444898
has license	cc0
sha1sum (hex)	cc146665ee73fa1830b7c42a24cd5844346c0f39
schema:url	https://doi.org/10.1371/journal.pone.0207440
resource representing a document's title	Detection of central nervous system viral infections in adults in Manado, North Sulawesi, Indonesia
has PubMed Central identifier	PMC6239303
has PubMed identifier	30444898
schema:publication	PLoS One
resource representing a document's body	covid:cc146665ee73fa1830b7c42a24cd5844346c0f39#body_text
is schema:about of	named entity 'HERPES SIMPLEX VIRUS 1' named entity 'WORLDWIDE' named entity 'COUNTRIES' named entity 'DETECTION METHODS' named entity 'ESTABLISHED' named entity 'ETIOLOGY' named entity 'ENROLLED' named entity 'VIRAL INFECTIONS' named entity 'IDENTIFIED' named entity 'IMPORTANT' named entity '282' named entity 'STUDY' named entity 'CNS' named entity 'VIRAL' named entity 'FOLLOWED BY' named entity 'MORBIDITY AND MORTALITY' named entity 'CEREBROSPINAL FLUID' named entity 'GENERAL HOSPITAL' named entity 'MANADO' named entity 'CNS INFECTION' named entity 'PERFORMED' named entity 'PROBABLE' named entity 'PATIENTS' named entity '1.6' named entity 'NORTH' named entity 'cytomegalovirus' named entity 'rhinovirus A' named entity 'virus' named entity 'confirmed' named entity 'morbidity' named entity 'DETECTION' named entity 'CHALLENGES' named entity 'DURING HOSPITALIZATION' named entity 'UNDIAGNOSED' named entity 'ADMITTED TO' named entity 'DENGUE VIRUS' named entity 'RANGE' named entity 'BUT' named entity 'USING' named entity 'HOSPITALS' named entity 'TO DETECT' named entity 'SEROLOGICAL' named entity 'FATAL' named entity 'SAMPLES' named entity 'THROAT SWAB' named entity 'ADULT' named entity 'MOST OF' named entity 'OBTAIN' named entity 'WIDE' named entity 'RHINOVIRUS A' named entity 'CNS INFECTIONS' named entity 'MANADO' covid:arg/cc146665ee73fa1830b7c42a24cd5844346c0f39 named entity 'VIRAL INFECTIONS' named entity 'SULAWESI' named entity 'ADULTS' named entity 'ADULTS' named entity 'MOLECULAR' named entity 'CAUSES' named entity 'INDONESIA' named entity 'EPSTEIN-BARR VIRUS' named entity '2.7' named entity 'ENTEROVIRUS D68' named entity 'TO IDENTIFY' named entity 'SURVEY'

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