About: The determination of treatment effect of chitosan oligosaccharide in lambs with experimentally cryptosporidiosis

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The determination of treatment effect of chitosan oligosaccharide in lambs with experimentally cryptosporidiosis
Creator	Aydogdu, Ugur Basbug, Onur Coskun, Alparslan Agaoglu, Zahid Duran Atas, Ahmet
Source	Elsevier; Medline; PMC
abstract	Abstract In this study, it was aimed to investigate the efficacy of chitosan oligosaccharide administrations in different doses of experimental infected lambs with Cryptosporidium parvum. 32 male lambs were used in the study and the lambs were divided into 4 groups with 8 lambs in each group. Groups 1, 2 and 3, twice a day, were administered chitosan oligosaccharide at a dose of 100, 500, and 1000 mg/kg for 7 days, respectively, with milk replacer. In group 4, lambs with cryptosporidiosis were subjected to normal feeding as control without drug administration. Clinical examinations of lambs were made before treatment (day 0) and on days 1, 3, 5 and 7 after treatment and 5 ml of blood was collected from vena jugularis for blood analysis of all lambs. Weight changes of lambs were recorded at 0, 7, 14, and 21 days. Stool specimens were collected pre-treatment (day 0) and on days 1, 3, 5, 7, 14 and 21 post-treatment to determine oocyst excretion of lambs with cryptosporidiosis. Lambs with a mean oocyte counts >10 after stool examination were included to the treatment. Changes in clinical hematology, blood gases and biochemical parameters were observed during the course of treatment, but these changes were limited. Weight loss was observed at 7th day according to 0th day the lambs with experimental cryptosporidiosis but gradually weight increase was observed at 14th and 21st days and these changes were similar in all groups. Oocyst excretion decreased in all groups during treatment. According to 0th day, there was a significant (p < 0.05) decrease in oocyte excretions in the third day in group 1 and 2, and in day 5 in the group 3 and 4. Significant changes (p < 0.05) were observed in oocyst excretions on the third and fifth days among the groups. As a result, in lambs with experimental cryptosporidiosis, chitosan oligosaccharide improved in clinical signs and stool character shorter than the positive control group and the administration of chitosan oligosaccharide at doses of 100, 500 and 1000 mg/kg for 7 days significantly reduced oocyst excretion but not enough to remove cryptosporidiosis completely.
has issue date	2019-11-30(xsd:dateTime)
bibo:doi	10.1016/j.smallrumres.2019.09.021
bibo:pmid	32288211
has license	els-covid
sha1sum (hex)	cc0b240ce6015c9bc86ef54a44416c52f5ab27a6
schema:url	https://doi.org/10.1016/j.smallrumres.2019.09.021
resource representing a document's title	The determination of treatment effect of chitosan oligosaccharide in lambs with experimentally cryptosporidiosis
has PubMed Central identifier	PMC7135297
has PubMed identifier	32288211
schema:publication	Small Ruminant Research
resource representing a document's body	covid:cc0b240ce6015c9bc86ef54a44416c52f5ab27a6#body_text
is schema:about of	named entity 'stool examination' named entity 'observed' named entity 'collected' named entity 'groups' named entity 'Cryptosporidium parvum' named entity 'Groups' named entity 'groups' named entity 'specimens' named entity 'cryptosporidiosis' covid:arg/cc0b240ce6015c9bc86ef54a44416c52f5ab27a6 named entity 'days' named entity 'lambs' named entity 'male' named entity 'recorded' named entity 'day' named entity 'weight' named entity 'excretion' named entity 'oligosaccharide' named entity 'days' named entity 'shorter' named entity 'day' named entity 'cryptosporidiosis' named entity 'lambs' named entity 'milk' named entity 'experimental' named entity 'oocyte' named entity 'oligosaccharide' named entity 'chitosan' named entity 'excretion' named entity 'control group' named entity 'oocyte' named entity 'chitosan' named entity 'cryptosporidiosis' named entity 'drug administration' named entity 'excretion' named entity 'clinical hematology' named entity 'cryptosporidiosis' named entity 'clinical signs' named entity 'cryptosporidiosis' named entity 'oligosaccharide' named entity 'cryptosporidiosis' named entity 'control group' named entity 'hypoglycemia' named entity 'severe diarrhea' named entity 'Infection' named entity 'Mindray' named entity 'medical field' named entity 'Istanbul' named entity 'chitosan' named entity 'oligosaccharide' named entity 'electrolytes' named entity 'oocysts' named entity 'chitosan' named entity 'Urea' named entity 'gas analyzer' named entity 'ruminants' named entity 'diarrhea' named entity 'oocysts' named entity 'neonatal' named entity 'biochemical' named entity 'Halofuginone' named entity 'HCO' named entity 'chitosan' named entity 'diarrhea' named entity 'diarrhea' named entity 'statistically significant' named entity 'partial pressure' named entity 'mucus' named entity 'Navarre' named entity 'mortality rates' named entity 'excretion' named entity 'blood pH' named entity 'intestines' named entity 'mucus' named entity 'lactate' named entity 'C. parvum' named entity 'clinical findings'

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