About: Influenza Virus A/Anhui/1/2013 (H7N9) Replicates Efficiently in the Upper and Lower Respiratory Tracts of Cynomolgus Macaques

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About: Influenza Virus A/Anhui/1/2013 (H7N9) Replicates Efficiently in the Upper and Lower Respiratory Tracts of Cynomolgus Macaques Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Influenza Virus A/Anhui/1/2013 (H7N9) Replicates Efficiently in the Upper and Lower Respiratory Tracts of Cynomolgus Macaques
Creator	Munster, Vincent Feldmann, Heinz Feldmann, Friederike Bushmaker, Trenton Chang, Jean Martellaro, Cynthia Okumura, Atsushi Proll, Sean Haddock, Elaine Gardner, Don De Wit, Emmie Katze, Michael Rasmussen, Angela
Source	Medline; PMC
abstract	In March 2013, three fatal human cases of infection with influenza A virus (H7N9) were reported in China. Since then, human cases have been accumulating. Given the public health importance of this virus, we performed a pathogenicity study of the H7N9 virus in the cynomolgus macaque model, focusing on clinical aspects of disease, radiographic, histological, and gene expression profile changes in the upper and lower respiratory tracts, and changes in systemic cytokine and chemokine profiles during infection. Cynomolgus macaques developed transient, mild to severe disease with radiographic evidence of pulmonary infiltration. Virus replicated in the upper as well as lower respiratory tract, with sustained replication in the upper respiratory tract until the end of the experiment at 6 days after inoculation. Virus shedding occurred mainly via the throat. Histopathological changes in the lungs were similar to those observed in humans, albeit less severe, with diffuse alveolar damage, infiltration of polymorphonuclear cells, formation of hyaline membranes, pneumocyte hyperplasia, and fibroproliferative changes. Analysis of gene expression profiles in lung lesions identified pathways involved in tissue damage during H7N9 infection as well as leads for development of therapeutics targeting host responses rather than virus replication. Overall, H7N9 infection was not as severe in cynomolgus macaques as in humans, supporting the possible role of underlying medical complications in disease severity as discussed for human H7N9 infection (H. N. Gao et al., N. Engl. J. Med. 368:2277–2285, 2013, doi:10.1056/NEJMoa1305584).
has issue date	2014-08-12(xsd:dateTime)
bibo:doi	10.1128/mbio.01331-14
bibo:pmid	25118237
has license	cc-by-nc-sa
sha1sum (hex)	cb5a49679732abf852dec6e61e435602706289c3
schema:url	https://doi.org/10.1128/mbio.01331-14
resource representing a document's title	Influenza Virus A/Anhui/1/2013 (H7N9) Replicates Efficiently in the Upper and Lower Respiratory Tracts of Cynomolgus Macaques
has PubMed Central identifier	PMC4145683
has PubMed identifier	25118237
schema:publication	mBio
resource representing a document's body	covid:cb5a49679732abf852dec6e61e435602706289c3#body_text
is schema:about of	named entity 'UPPER' named entity 'SUPPORTING' named entity 'POLYMORPHONUCLEAR CELLS' named entity 'CLINICAL ASPECTS' named entity 'H7N9' named entity 'UNDERLYING' named entity 'PATHWAYS' named entity 'LUNG' named entity 'CHINA' named entity 'FOCUSING' named entity 'RATHER' named entity 'HYPERPLASIA' named entity 'ANALYSIS' named entity 'LOWER' named entity 'REPLICATION' named entity 'EVIDENCE OF' named entity 'THROAT' named entity 'INVOLVED' named entity 'CHEMOKINE' named entity 'CYNOMOLGUS MACAQUE' named entity 'REPLICATED' named entity 'IDENTIFIED' named entity 'THE LUNGS' named entity 'ROLE' named entity 'INOCULATION' named entity 'CHANGES' named entity 'SYSTEMIC' named entity 'human' named entity 'Engl.' named entity 'disease' named entity 'H7N9' named entity 'upper' named entity 'infection' named entity 'identified' named entity 'humans' named entity 'upper' named entity 'mild' named entity 'disease' named entity 'Influenza' named entity 'H7N9' named entity 'GIVEN' named entity 'HOST' named entity 'HUMAN' named entity 'RESPIRATORY TRACTS' named entity 'SEVERE DISEASE' named entity 'TARGETING' named entity 'MILD' named entity 'ACCUMULATING' named entity 'HUMANS' named entity 'SIMILAR' named entity 'POSSIBLE' named entity 'THERAPEUTICS' named entity 'SUSTAINED' named entity 'LOWER' named entity 'MACAQUES' named entity 'CYNOMOLGUS' named entity '2F1' named entity 'INFLUENZA VIRUS A' named entity 'FORMATION' named entity 'INFLUENZA A VIRUS' named entity 'OVERALL' named entity 'UPPER RESPIRATORY TRACT' named entity 'END' named entity 'RADIOGRAPHIC' named entity 'PATHOGENICITY' named entity 'VIRUS SHEDDING' named entity 'PERFORMED' named entity 'ENGL' named entity 'OBSERVED'

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