About: Antagonistic Pleiotropy and Fitness Trade-Offs Reveal Specialist and Generalist Traits in Strains of Canine Distemper Virus

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Antagonistic Pleiotropy and Fitness Trade-Offs Reveal Specialist and Generalist Traits in Strains of Canine Distemper Virus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Antagonistic Pleiotropy and Fitness Trade-Offs Reveal Specialist and Generalist Traits in Strains of Canine Distemper Virus
Creator	Anderson, D Hofer, H Nikolin, V Osterrieder, K Von Messling, V
topic	covid:cb43de0358c05aba59dfb4957432fc2cbe31b30e#this
Source	PMC
abstract	Theoretically, homogeneous environments favor the evolution of specialists whereas heterogeneous environments favor generalists. Canine distemper is a multi-host carnivore disease caused by canine distemper virus (CDV). The described cell receptor of CDV is SLAM (CD150). Attachment of CDV hemagglutinin protein (CDV-H) to this receptor facilitates fusion and virus entry in cooperation with the fusion protein (CDV-F). We investigated whether CDV strains co-evolved in the large, homogeneous domestic dog population exhibited specialist traits, and strains adapted to the heterogeneous environment of smaller populations of different carnivores exhibited generalist traits. Comparison of amino acid sequences of the SLAM binding region revealed higher similarity between sequences from Canidae species than to sequences from other carnivore families. Using an in vitro assay, we quantified syncytia formation mediated by CDV-H proteins from dog and non-dog CDV strains in cells expressing dog, lion or cat SLAM. CDV-H proteins from dog strains produced significantly higher values with cells expressing dog SLAM than with cells expressing lion or cat SLAM. CDV-H proteins from strains of non-dog species produced similar values in all three cell types, but lower values in cells expressing dog SLAM than the values obtained for CDV-H proteins from dog strains. By experimentally changing one amino acid (Y549H) in the CDV-H protein of one dog strain we decreased expression of specialist traits and increased expression of generalist traits, thereby confirming its functional importance. A virus titer assay demonstrated that dog strains produced higher titers in cells expressing dog SLAM than cells expressing SLAM of non-dog hosts, which suggested possible fitness benefits of specialization post-cell entry. We provide in vitro evidence for the expression of specialist and generalist traits by CDV strains, and fitness trade-offs across carnivore host environments caused by antagonistic pleiotropy. These findings extend knowledge on CDV molecular epidemiology of particular relevance to wild carnivores.
has issue date	2012-12-11(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0050955
bibo:pmid	23239996
has license	cc-by
sha1sum (hex)	cb43de0358c05aba59dfb4957432fc2cbe31b30e
schema:url	https://doi.org/10.1371/journal.pone.0050955
resource representing a document's title	Antagonistic Pleiotropy and Fitness Trade-Offs Reveal Specialist and Generalist Traits in Strains of Canine Distemper Virus
has PubMed Central identifier	PMC3519774
has PubMed identifier	23239996
schema:publication	PLoS One
resource representing a document's body	covid:cb43de0358c05aba59dfb4957432fc2cbe31b30e#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/cb43de0358c05aba59dfb4957432fc2cbe31b30e
is schema:about of	named entity 'FITNESS' named entity 'traits' named entity 'SLAM' named entity 'species' named entity 'carnivores' named entity 'heterogeneous' named entity 'homogeneous' named entity 'demonstrated' named entity 'cooperation' named entity 'dog' named entity 'evolution' named entity 'changing' named entity 'syncytia' named entity 'caused' named entity 'expressing' named entity 'titers' named entity 'CARNIVORES' named entity 'LION' named entity 'HETEROGENEOUS' named entity 'WILD' named entity 'CELL TYPES' named entity 'HIGHER' named entity 'POPULATION' named entity 'FUNCTIONAL' named entity 'TITER' named entity 'CELL' named entity 'SPECIALIST' named entity 'LARGE' named entity 'OBTAINED' named entity 'FAMILIES' named entity 'ENVIRONMENT' named entity 'FAVOR' named entity 'EVOLVED' named entity 'STRAIN' named entity 'AMINO ACID SEQUENCES' named entity 'PROVIDE' named entity 'DISEASE' named entity 'SMALLER' named entity 'EVOLUTION' named entity 'VIRUS' named entity 'CAUSED BY' named entity 'H PROTEIN' named entity 'FUSION PROTEIN' named entity 'CARNIVORE' named entity 'COOPERATION' named entity 'VALUES' named entity 'CANINE DISTEMPER VIRUS' named entity 'IS A' named entity 'BUT' named entity 'INVESTIGATED' named entity 'SIMILARITY' named entity 'SEQUENCES' named entity 'IN VITRO' named entity 'THESE' named entity 'HOST' named entity 'VIRUS ENTRY' named entity 'ENVIRONMENTS' named entity 'DECREASED EXPRESSION' named entity 'CHANGING' named entity 'CONFIRMING' named entity 'SPECIALISTS' named entity 'REVEALED' named entity 'PARTICULAR' named entity 'SPECIALIZATION' named entity 'PLEIOTROPY' named entity 'COMPARISON' named entity 'MULTI' named entity 'FUSION' named entity 'POSSIBLE' named entity 'RECEPTOR' named entity 'SPECIES' named entity 'CDV' named entity 'POST' covid:arg/cb43de0358c05aba59dfb4957432fc2cbe31b30e named entity 'GENERALIST'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software