About: Pyrazolone structural motif in medicinal chemistry: Retrospect and prospect

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Pyrazolone structural motif in medicinal chemistry: Retrospect and prospect Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Pyrazolone structural motif in medicinal chemistry: Retrospect and prospect
Creator	Wang, Xiao Zhang, Yongmin He, Xirui Wu, Shaoping Xie, Jing Zhao, Zefeng Zheng, Xiaohui Li, Chenyang Dai, Xufen Fan, Peinan Feng, Ying Ma, Cong Nie, Zhuang Qian, Mingcheng Tian, Jiale
Source	Elsevier; Medline; PMC
abstract	Abstract The pyrazolone structural motif is a critical element of drugs aimed at different biological end-points. Medicinal chemistry researches have synthesized drug-like pyrazolone candidates with several medicinal features including antimicrobial, antitumor, CNS (central nervous system) effect, anti-inflammatory activities and so on. Meanwhile, SAR (Structure-Activity Relationship) investigations have drawn attentions among medicinal chemists, along with a plenty of analogues have been derived for multiple targets. In this review, we comprehensively summarize the biological activity and SAR for pyrazolone analogues, wishing to give an overall retrospect and prospect on the pyrazolone derivatives.
has issue date	2020-01-15(xsd:dateTime)
bibo:doi	10.1016/j.ejmech.2019.111893
bibo:pmid	31761383
has license	els-covid
sha1sum (hex)	cb16d307afaecebd683e6d74c8b501ed54b0c9a4
schema:url	https://doi.org/10.1016/j.ejmech.2019.111893
resource representing a document's title	Pyrazolone structural motif in medicinal chemistry: Retrospect and prospect
has PubMed Central identifier	PMC7115706
has PubMed identifier	31761383
schema:publication	European Journal of Medicinal Chemistry
resource representing a document's body	covid:cb16d307afaecebd683e6d74c8b501ed54b0c9a4#body_text
is schema:about of	named entity 'element' named entity 'analogues' named entity 'pyrazolone' named entity 'structural motif' named entity 'REVIEW' named entity 'ANTITUMOR' named entity 'ACTIVITY' named entity 'INCLUDING' named entity 'IS A' named entity 'FEATURES' named entity 'END' named entity 'STRUCTURAL MOTIF' named entity 'ANTI-INFLAMMATORY' named entity 'PYRAZOLONE' named entity 'NERVOUS SYSTEM' named entity 'CRITICAL' named entity 'INVESTIGATIONS' named entity 'STRUCTURAL MOTIF' named entity 'PROSPECT' named entity 'PYRAZOLONE' named entity 'MEDICINAL CHEMISTRY' named entity 'SAR' named entity 'DRUG' named entity 'PYRAZOLONE DERIVATIVES' named entity 'ELEMENT' named entity 'HAVE' named entity 'OVERALL' named entity 'PROSPECT' named entity 'CHEMISTS' named entity 'EFFECT' named entity 'DERIVED' named entity 'DRUGS' named entity 'TARGETS' named entity 'POINTS' named entity 'MEDICINAL CHEMISTRY' named entity 'DIFFERENT' named entity 'RELATIONSHIP' named entity 'ANTIMICROBIAL' named entity 'BIOLOGICAL' named entity 'BIOLOGICAL ACTIVITY' named entity 'PLENTY' named entity 'SYNTHESIZED' named entity 'MULTIPLE' named entity 'ACTIVITIES' named entity 'LIKE' named entity 'CNS' named entity 'ATTENTIONS' named entity 'targets' named entity 'anti-inflammatory' named entity 'retrospect' named entity 'CNS' named entity 'Pyrazolone' named entity 'potency' named entity 'E. coli' named entity 'thiourea derivatives' named entity 'protein' named entity 'TNF-a' named entity 'pyrans' named entity 'potency' named entity 'benzyl' named entity 'cytotoxic' named entity 'pharmacological' named entity 'carbonyl group' named entity 'nitrogen' named entity 'heterocyclic' named entity 'potency' named entity 'antitumor'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software