About: Bacterial Outer Membrane Vesicles (OMVs)-Based Dual Vaccine for Influenza A H1N1 Virus and MERS-CoV

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About: Bacterial Outer Membrane Vesicles (OMVs)-Based Dual Vaccine for Influenza A H1N1 Virus and MERS-CoV Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Bacterial Outer Membrane Vesicles (OMVs)-Based Dual Vaccine for Influenza A H1N1 Virus and MERS-CoV
Creator	Kayali, Ghazi Chakraborty, Trinad Kandeil, Ahmed Mahmoud, Sara Mostafa, Ahmed Pleschka, Stephan Shehata, Mahmoud Ali, Mohamed Elshesheny, Rabeh Frantz, Renate Osman, Ahmed Teubner, Lisa Boubak, Thamer Mraheil, Mobarak Pietra, Luigi
source	Medline; PMC
abstract	Vaccination is the most functional medical intervention to prophylactically control severe diseases caused by human-to-human or animal-to-human transmissible viral pathogens. Annually, seasonal influenza epidemics attack human populations leading to 290–650 thousand deaths/year worldwide. Recently, a novel Middle East Respiratory Syndrome Coronavirus emerged. Together, those two viruses present a significant public health burden in areas where they circulate. Herein, we generated a bacterial outer membrane vesicles (OMVs)-based vaccine presenting the antigenic stable chimeric fusion protein of the H1-type haemagglutinin (HA) of the pandemic influenza A virus (H1N1) strain from 2009 (H1N1pdm09) and the receptor binding domain (RBD) of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) (OMVs-H1/RBD). Our results showed that the chimeric antigen could induce specific neutralizing antibodies against both strains leading to protection of immunized mice against H1N1pdm09 and efficient neutralization of MERS-CoV. This study demonstrate that OMVs-based vaccines presenting viral antigens provide a safe and reliable approach to protect against two different viral infections.
has issue date	2019-05-28(xsd:dateTime)
bibo:doi	10.3390/vaccines7020046
bibo:pmid	31141982
has license	cc-by
sha1sum (hex)	caacab8201dadba7c322aaebad07309ef12e3c93
schema:url	https://doi.org/10.3390/vaccines7020046
resource representing a document's title	Bacterial Outer Membrane Vesicles (OMVs)-Based Dual Vaccine for Influenza A H1N1 Virus and MERS-CoV
has PubMed Central identifier	PMC6631769
has PubMed identifier	31141982
schema:publication	Vaccines (Basel)
resource representing a document's body	covid:caacab8201dadba7c322aaebad07309ef12e3c93#body_text
is schema:about of	named entity 'BASED' named entity 'BACTERIAL OUTER MEMBRANE' named entity 'H1N1' named entity 'UNI' named entity 'WORK' named entity 'INFLUENZA A' named entity '80%' named entity 'MERS-COV' named entity 'VACCINE' named entity 'DUAL' named entity 'VIRUS' named entity 'MED' named entity 'GIESSEN' named entity 'THESE' named entity 'VESICLES' named entity 'AUTHORS' named entity 'A.M.' covid:arg/caacab8201dadba7c322aaebad07309ef12e3c93 named entity 'BSL2' named entity '20%' named entity 'RBD' named entity 'Invitrogen' named entity 'kDa' named entity 'health topics' named entity 'Syringe Filter' named entity 'control group' named entity 'positive controls' named entity 'MERS-CoV' named entity 'M2e' named entity 'M.A.A' named entity 'Vaccine' named entity 'Bacterial Outer Membrane Vesicles' named entity 'H1N1' named entity 'Chlamydia trachomatis' named entity 'PBS' named entity 'BALB/c' named entity 'Acinetobacter baumannii' named entity 'plaque reduction neutralization test' named entity 'Vibrio cholera' named entity 'LPS' named entity 'immune responses' named entity 'β-mercaptoethanol' named entity 'MERS-CoV' named entity 'outer surface' named entity 'control group' named entity 'infection' named entity 'immunogenic' named entity 'anesthetized' named entity 'titer' named entity 'swine-origin H1N1 influenza' named entity 'fusion protein' named entity 'protein' named entity 'humoral' named entity 'RBD' named entity 'immunogenicity' named entity 'control group' named entity 'immunization' named entity 'PBS' named entity 'euthanasia' named entity 'incubation' named entity 'amino acids' named entity 'plasmids' named entity 'coding sequence' named entity 'vaccine' named entity 'Body weight' named entity 'tissue culture' named entity 'Tris-HCl'

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