About: Activated macrophages are the main inflammatory cell in COVID-19 interstitial pneumonia infiltrates. Is it possible to show their metabolic activity and thus the grade of inflammatory burden with (18)F-Fluorocholine PET/CT?

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About: Activated macrophages are the main inflammatory cell in COVID-19 interstitial pneumonia infiltrates. Is it possible to show their metabolic activity and thus the grade of inflammatory burden with (18)F-Fluorocholine PET/CT? Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Activated macrophages are the main inflammatory cell in COVID-19 interstitial pneumonia infiltrates. Is it possible to show their metabolic activity and thus the grade of inflammatory burden with (18)F-Fluorocholine PET/CT?
Creator	Rizzo, A Bonacina, M Savelli, G Zaniboni, A
source	Elsevier; Medline; PMC
abstract	The recent outbreak of Covid-19 has represented a major challenge for the countries affected by the disease, not only in terms of loss of human life, economic downturn, and constraint on individual freedom, but also for the great pressure on the national health systems and hospitals. The 380 kDa virus has been a perfect storm, especially for those national health systems used to working with limited resources and high intensity rhythms, such as Italy. For the first time in the new century, a virtually unknown fast-spreading disease has caused a public health emergency thus forcing most countries to deal with an insurmountable logistic gap. Hence, every branch of Medicine, even though not directly involved in the treatment, has been called upon to provide its contribution to resolve the crisis. It is now becoming more apparent that Covid-19 is not solely a lung disease, but a complex systemic disease involving several organs and systems. This is due to an abnormal inflammatory response which eventually leads to multisystemic coagulopathy which mainly, but not uniquely, targets the lungs. Although the pathophysiology of this syndrome is still not fully understood, macrophages and their immune complex system seem to play a key role. It is not yet clear why some patients develop the violent immune response which results in pneumonitis while others do not. There are clues indicating that the systemic hyper-inflammation defined as macrophage activation syndrome (MAS), or cytokine storm, requires an increase in choline consumption to synthesize phosphatidylcholine and stimulate phagocytosis, organelle biogenesis, secretory functions, and endocytosis. (18)F-Fluorocholine is a synthetic analog of the naturally occurring choline normally used for PET/CT imaging of prostate cancer patients. (18)F-Fluorocholine could image and quantify the macrophage activity in pulmonary interstitial infiltrates of Covid-19 pneumonia. If the hypothesis is confirmed experimentally, (18)F-Fluorocholine PET/CT could be used to in vivo image and quantify the degree of lung inflammation and potentially stratify the gravity of this disease.
has issue date	2020-05-27(xsd:dateTime)
bibo:doi	10.1016/j.mehy.2020.109885
bibo:pmid	32540605
has license	no-cc
sha1sum (hex)	ca3c2aefff5b7bf30c223da9eb2411ca0efd6ddc
schema:url	https://doi.org/10.1016/j.mehy.2020.109885
resource representing a document's title	Activated macrophages are the main inflammatory cell in COVID-19 interstitial pneumonia infiltrates. Is it possible to show their metabolic activity and thus the grade of inflammatory burden with (18)F-Fluorocholine PET/CT?
has PubMed Central identifier	PMC7252431
has PubMed identifier	32540605
schema:publication	Med Hypotheses
resource representing a document's body	covid:ca3c2aefff5b7bf30c223da9eb2411ca0efd6ddc#body_text
is schema:about of	named entity 'high' named entity 'national health' named entity 'human' named entity 'Title' named entity 'COVID-19' named entity 'HEALTH SYSTEMS' named entity 'perfect storm' named entity 'health systems' named entity 'high intensity' named entity 'health systems' named entity 'Covid-19' named entity 'interstitial pneumonia' named entity 'inflammatory cell' named entity 'inflammatory' named entity 'national health' named entity 'hyperplasia' named entity 'macrophage' named entity 'public health' named entity 'Phospholipids' named entity 'immune complex' named entity 'pneumonitis' named entity 'severe acute respiratory syndrome' named entity 'macrophages' named entity 'macrophages' named entity 'MAS' named entity 'respiratory symptoms' named entity 'inflammatory cytokine' named entity 'ground-glass opacities' named entity 'phospholipid' named entity 'spreading disease' named entity 'inflammation' named entity 'Covid' named entity 'ageusia' named entity 'biogenesis' named entity 'prostate cancer' named entity 'alveolar' named entity 'cell membranes' named entity 'inflammatory response' named entity 'global pandemic' named entity 'choline' named entity 'organelle' named entity 'fatigue' named entity 'biogenesis' named entity 'Covid-19' named entity 'choline' named entity 'choline' named entity 'lung inflammation' named entity 'noxa' named entity 'PET' named entity 'immune response' named entity 'phagocytosis' named entity 'systemic disease' named entity 'Coronavirus disease' named entity 'macrophages' named entity 'cough' named entity 'organelle' named entity 'Fluorocholine' named entity 'macrophage activation syndrome' named entity 'Fluorocholine' named entity 'subpleural' named entity 'dysgeusia' named entity 'prostate adenocarcinoma' named entity 'China' named entity 'cytokine storm' named entity 'branch of Medicine' named entity 'infection' named entity 'type II pneumocyte' named entity 'pathogenetic' named entity 'mild fever' named entity 'follow-up' named entity 'anosmia' named entity 'Covid' named entity 'lung disease' named entity 'Covid' named entity 'alveolar' named entity 'U.S.' named entity 'Europe' named entity 'choline'

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