About: Functional cell models of the gut and their applications in food microbiology

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About: Functional cell models of the gut and their applications in food microbiology — A review Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Functional cell models of the gut and their applications in food microbiology — A review
Creator	Cencič, Avrelija Langerholc, Tomaž
Source	Elsevier; Medline; PMC
abstract	Abstract Animal experimentation has a long tradition for risk assessment of new drugs before they reach the clinic. To reduce expensive animal experimentation, attempts have been made to build inexpensive and convenient intestinal functional cell models to study toxicity and bioavailability of new substances along with providing relevant models to study interactions between the host, pathogens and intestinal microflora. We review the available cell lines and models of the intestine and their potential uses. Tumor derived cell lines such as Caco-2, T84 and HT-29 are widely used despite many drawbacks, which are discussed with respect to complexity of the gut, where various cell types interact with commensal microbiota and gut-associated lymphoid tissue. To address this complexity, 3D models of human and animal gut represent a promising in vitro system to mimic in vivo situation without the use of transformed cell lines.
has issue date	2010-07-31(xsd:dateTime)
bibo:doi	10.1016/j.ijfoodmicro.2010.03.026
bibo:pmid	20444515
has license	els-covid
sha1sum (hex)	ca2393e13bfbb31f53fbbb4602bc47a2fdc86be1
schema:url	https://doi.org/10.1016/j.ijfoodmicro.2010.03.026
resource representing a document's title	Functional cell models of the gut and their applications in food microbiology — A review
has PubMed Central identifier	PMC7173225
has PubMed identifier	20444515
schema:publication	International Journal of Food Microbiology
resource representing a document's body	covid:ca2393e13bfbb31f53fbbb4602bc47a2fdc86be1#body_text
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