About: Anti‐HIV, Anti‐Poxvirus, and Anti‐SARS Activity of a Nontoxic, Acidic Plant Extract from the Trifollium Species Secomet‐V/anti‐Vac Suggests That It Contains a Novel Broad‐Spectrum Antiviral

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About: Anti‐HIV, Anti‐Poxvirus, and Anti‐SARS Activity of a Nontoxic, Acidic Plant Extract from the Trifollium Species Secomet‐V/anti‐Vac Suggests That It Contains a Novel Broad‐Spectrum Antiviral Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Anti‐HIV, Anti‐Poxvirus, and Anti‐SARS Activity of a Nontoxic, Acidic Plant Extract from the Trifollium Species Secomet‐V/anti‐Vac Suggests That It Contains a Novel Broad‐Spectrum Antiviral
Creator	Preiser, Wolfgang Kotwal, Girish Abdu, And Bauer, Gabriele De Beer, Corena Ghebremariam, Yohannes Kaczmarek, Jennifer Kulkarni, Amod Leivers, Steven Mohamed, Rahman
Source	PMC
abstract	Enveloped animal viruses such as human immunodeficiency virus (HIV), hepatitis B virus, hepatitis C virus, human papillomavirus, Marburg, and influenza are major public health concerns around the world. The prohibitive cost of antiretroviral (ARV) drugs for most HIV‐infected patients in sub‐Saharan Africa and the serious side effects in those who have access to ARV drugs make a compelling case for the study of complementary and alternative therapies. Such therapies should have scientifically proved antiviral activity and minimal toxic effects. A plant extract, Secomet‐V, with an anecdotal indication in humans for promise as an anti‐HIV treatment, was investigated. Using a previously described attenuated vaccinia virus vGK5, we established the antiviral activity of Secomet‐V. Chemical analysis showed that it has an acidic pH, nontoxic traces of iron (<10 ppm), and almost undetectable levels of arsenic (<1.0 ppm). The color varies from colorless to pale yellow to dark brown. The active agent is heat stable at least up to sterilizing temperature of 121°C. The crude plant extract is a mixture of several small molecules separable by high‐pressure liquid chromatography. The HIV viral loads were significantly reduced over several months in a few patients monitored after treatment with Secomet‐V. Secomet‐V was also found to have antiviral activity against the SARS virus but not against the West Nile virus. Secomet‐V, therefore, is a broad‐spectrum antiviral, which possibly works by neutralizing viral infectivity, resulting in the prevention of viral attachment.
has issue date	2006-01-22(xsd:dateTime)
bibo:doi	10.1196/annals.1352.014
bibo:pmid	16387696
has license	no-cc
sha1sum (hex)	c9dce95ed63aa1df903562b024e4ce9dd8dc45bf
schema:url	https://doi.org/10.1196/annals.1352.014
resource representing a document's title	Anti‐HIV, Anti‐Poxvirus, and Anti‐SARS Activity of a Nontoxic, Acidic Plant Extract from the Trifollium Species Secomet‐V/anti‐Vac Suggests That It Contains a Novel Broad‐Spectrum Antiviral
has PubMed Central identifier	PMC7167892
has PubMed identifier	16387696
schema:publication	Ann N Y Acad Sci
resource representing a document's body	covid:c9dce95ed63aa1df903562b024e4ce9dd8dc45bf#body_text
is schema:about of	named entity 'HEALTH CONCERNS' named entity 'ANNALS' named entity 'FOUND' named entity 'human immunodeficiency virus' named entity 'antiretroviral' named entity 'plant extract' named entity 'animal viruses' named entity 'iron' named entity 'HIV' named entity 'antiviral activity' named entity 'nontoxic' named entity 'high-pressure liquid chromatography' named entity 'hepatitis B virus' named entity 'Plant Extract' named entity 'SARS' named entity 'Nontoxic' named entity 'viremia' named entity 'herbal medicine' named entity 'cytotoxicity' named entity 'antiviral activity' named entity 'carcinogenic' named entity 'infectivity' named entity 'HIV' named entity 'ultrafiltration' named entity 'health problems' named entity 'factor 8' named entity 'noninfectious' named entity 'vaccinia virus' named entity 'Autoclaving' named entity '1 million' named entity 'cell lines' named entity 'influenza virus' named entity 'HIV' named entity 'cell lines' named entity 'salicylic acid' named entity 'wild-type' named entity 'peptide' named entity 'vaccinia virus' named entity 'phosphate-buffered saline' named entity 'Western Cape' named entity 'attenuated virus' named entity 'antiviral therapy' named entity 'crystal violet' named entity 'virus' named entity 'autoclaved' named entity 'metabolic' named entity 'recombinant' named entity 'HIV' named entity 'enveloped viruses' named entity 'viral infections' named entity 'UNAIDS' named entity 'virus' named entity 'vaccinia virus' named entity '10 million' named entity 'virus' named entity 'viral infections' named entity 'antiviral activity' named entity 'active ingredient' named entity 'titer' named entity 'antiserum' named entity 'Enveloped viruses' named entity 'virus' named entity 'antiviral agent' named entity 'mutagenic activity' named entity 'HIV-1' named entity 'HIV' named entity 'antiviral' named entity 'HIV testing' named entity 'antiretroviral' named entity 'viremia' named entity 'Salmonella' named entity 'recombinant'

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