About: Post-mortem diagnosis, of cytomegalovirus and varicella zoster virus co-infection by combined histology and tissue molecular biology, in a sudden unexplained infant death

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About: Post-mortem diagnosis, of cytomegalovirus and varicella zoster virus co-infection by combined histology and tissue molecular biology, in a sudden unexplained infant death Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Post-mortem diagnosis, of cytomegalovirus and varicella zoster virus co-infection by combined histology and tissue molecular biology, in a sudden unexplained infant death
Creator	Andreoletti, Laurent Boulagnon, Camille Desmons, Aurore Digeon, Beatrice Fornes, Paul Giusti, Delphine Leveque, Nicolas Nguyen, Yohan Terrade, Caroline
Source	Elsevier; Medline; PMC
abstract	BACKGROUND: An autopsy case of a two-month-old male infant who suddenly and unexpectedly died during his sleep, eight days after the onset of benign varicella. OBJECTIVES: To describe post-mortem combined histological and tissue molecular biological techniques for the diagnosis of cytomegalovirus and varicella zoster virus co-infection as a cause of death. STUDY DESIGN: Real-time quantitative PCR and RT-PCR assays for Herpesviruses, respiratory viruses, Adenovirus, Enterovirus and Parvovirus B19 were performed on multi-organ frozen samples and paraffin-embedded tissues in combination with histology. RESULTS: Cytomegalovirus and varicella zoster virus were detected by molecular biology with highest viral loads detected in the lungs (4.6 × 10(7) and 1.9 × 10(5) genome copies per million of cells, respectively). Pulmonary extensive necrotizing inflammation and immunohistochemistry correlated to virological data. Virological molecular biology was negative on paraffin-embedded tissues. CONCLUSIONS: This case shows that thorough quantitative virological investigations on frozen tissues must be performed in combination with histology and immunohistochemistry for the determination of the cause of a sudden unexplained infant death.
has issue date	2013-08-15(xsd:dateTime)
bibo:doi	10.1016/j.jcv.2013.08.007
bibo:pmid	24001883
has license	no-cc
sha1sum (hex)	c97c091877edc3d7e583abf2f412ae05ca7240ef
schema:url	https://doi.org/10.1016/j.jcv.2013.08.007
resource representing a document's title	Post-mortem diagnosis, of cytomegalovirus and varicella zoster virus co-infection by combined histology and tissue molecular biology, in a sudden unexplained infant death
has PubMed Central identifier	PMC7128706
has PubMed identifier	24001883
schema:publication	J Clin Virol
resource representing a document's body	covid:c97c091877edc3d7e583abf2f412ae05ca7240ef#body_text
is schema:about of	named entity 'molecular biological' named entity 'samples' named entity 'sleep' named entity 'BENIGN' named entity 'THE LUNGS' named entity 'DAYS' named entity 'HERPESVIRUSES' named entity 'STUDY DESIGN' named entity 'OBJECTIVES' named entity 'VIROLOGICAL' named entity '1.9' named entity 'CORRELATED' named entity 'RESPIRATORY VIRUSES' named entity 'POST-MORTEM' named entity 'PER MILLION' named entity 'PERFORMED' named entity 'CYTOMEGALOVIRUS' named entity 'TISSUES' named entity 'CO-INFECTION' named entity 'SLEEP' named entity 'RT-PCR' named entity 'EXTENSIVE' named entity 'HISTOLOGY' named entity 'ADENOVIRUS' named entity 'TECHNIQUES' named entity 'BACKGROUND' named entity 'HISTOLOGICAL' named entity 'TO DESCRIBE' named entity 'VIRAL' named entity 'IMMUNOHISTOCHEMISTRY' named entity 'COMBINED' named entity 'AUTOPSY' named entity 'DIED' named entity 'NEGATIVE' named entity 'GENOME' named entity 'REAL-TIME QUANTITATIVE PCR' named entity 'PULMONARY' named entity 'MULTI' named entity 'COMBINATION' named entity 'DATA' named entity 'MOLECULAR BIOLOGY' named entity 'BIOLOGICAL' named entity 'VARICELLA ZOSTER VIRUS' named entity 'DIAGNOSIS' named entity 'MONTH' named entity 'TISSUE' named entity 'MOLECULAR' named entity 'NECROTIZING INFLAMMATION' named entity 'PARVOVIRUS B19' named entity 'INFANT' named entity 'VARICELLA' named entity 'CELLS' named entity 'SAMPLES' named entity 'CAUSE OF DEATH' named entity 'COPIES' named entity 'FROZEN' named entity 'ONSET OF' named entity 'ENTEROVIRUS' named entity 'ORGAN' named entity 'PARAFFIN-EMBEDDED' named entity 'RESULTS' named entity 'HIGHEST' named entity 'MALE' named entity 'DETECTED' named entity 'OLD' named entity 'CASE' covid:arg/c97c091877edc3d7e583abf2f412ae05ca7240ef named entity 'benign' named entity 'tissue' named entity 'autopsy' named entity 'histological' named entity 'Results' named entity 'Enterovirus'

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