About: Rapid isolation and profiling of a diverse panel of human monoclonal antibodies targeting the SARS-CoV-2 spike protein

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About: Rapid isolation and profiling of a diverse panel of human monoclonal antibodies targeting the SARS-CoV-2 spike protein Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Rapid isolation and profiling of a diverse panel of human monoclonal antibodies targeting the SARS-CoV-2 spike protein
Creator	Baric, Ralph Gilchuk, Pavlo Carnahan, Robert Nargi, Rachel Diamond, Michael Case, James Chu, Helen Crowe, James Ostrowski, Mario Thackray, Larissa Bursky, Jane Lee, Eun-Hyung Binshtein, Elad Chen, Rita Chen, Elaine Day, Samuel Didier, Jonathan Jones, Taylor Macrenaris, Keith Martinez, David Myers, Luke Naveenchandra, Nguyen, Doan Reidy, Sanz, Ignacio Shrihari, Swathi Sutton, Rachel Trivette, Andrew Zost, Seth
Source	BioRxiv; Medline
abstract	Antibodies are a principal determinant of immunity for most RNA viruses and have promise to reduce infection or disease during major epidemics. The novel coronavirus SARS-CoV-2 has caused a global pandemic with millions of infections and hundreds of thousands of deaths to date1,2. In response, we used a rapid antibody discovery platform to isolate hundreds of human monoclonal antibodies (mAbs) against the SARS-CoV-2 spike (S) protein. We stratify these mAbs into five major classes based on their reactivity to subdomains of S protein as well as their cross-reactivity to SARS-CoV. Many of these mAbs inhibit infection of authentic SARS-CoV-2 virus, with most neutralizing mAbs recognizing the receptor-binding domain (RBD) of S. This work defines sites of vulnerability on SARS-CoV-2 S and demonstrates the speed and robustness of new antibody discovery methodologies.
has issue date	2020-05-13(xsd:dateTime)
bibo:doi	10.1101/2020.05.12.091462
bibo:pmid	32511414
has license	biorxiv
sha1sum (hex)	c9628d9ac274d744dd89c708503923943400880a
schema:url	https://doi.org/10.1101/2020.05.12.091462
resource representing a document's title	Rapid isolation and profiling of a diverse panel of human monoclonal antibodies targeting the SARS-CoV-2 spike protein
has PubMed identifier	32511414
schema:publication	bioRxiv
resource representing a document's body	covid:c9628d9ac274d744dd89c708503923943400880a#body_text
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