About: Role of the GTNGTKR motif in the N-terminal receptor-binding domain of the SARS-CoV-2 spike protein

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About: Role of the GTNGTKR motif in the N-terminal receptor-binding domain of the SARS-CoV-2 spike protein Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Role of the GTNGTKR motif in the N-terminal receptor-binding domain of the SARS-CoV-2 spike protein
Creator	Baha, Sarra Behloul, Nouredine Meng, Jihong Shi, Ruihua
topic	covid:c94ef620e69c5b065486edee798854adb3c3d49b#this
Source	Elsevier; Medline; PMC
abstract	The 2019 novel coronavirus disease (COVID-19) that emerged in China has been declared as public health emergency of international concern by the World Health Organization and the causative pathogen was named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In this report, we analyzed the structural characteristics of the N-terminal domain of the S1 subunit (S1-NTD) of the SARS-CoV-2 spike protein in comparison to the SARS-CoV in particular, and to other viruses presenting similar characteristic in general. Given the severity and the wide and rapid spread of the SARS-CoV-2 infection, it is very likely that the virus recognizes other receptors/co-receptors besides the ACE2. The NTD of the SARS-CoV-2 contains a receptor-binding motif different from that of SARS-CoV, with some insertions that could confer to the new coronavirus new receptor binding abilities. In particular, motifs similar to the insertion 72GTNGTKR78 have been found in structural proteins of other viruses; and these motifs were located in putative regions involved in recognizing protein and sugar receptors, suggesting therefore that similar binding abilities could be displayed by the SARS-CoV-2 S1-NTD. Moreover, concerning the origin of these NTD insertions, our findings point towards an evolutionary acquisition rather than the hypothesis of an engineered virus.
has issue date	2020-06-09(xsd:dateTime)
bibo:doi	10.1016/j.virusres.2020.198058
bibo:pmid	32531235
has license	no-cc
sha1sum (hex)	c94ef620e69c5b065486edee798854adb3c3d49b
schema:url	https://doi.org/10.1016/j.virusres.2020.198058
resource representing a document's title	Role of the GTNGTKR motif in the N-terminal receptor-binding domain of the SARS-CoV-2 spike protein
has PubMed Central identifier	PMC7282740
has PubMed identifier	32531235
schema:publication	Virus Res
resource representing a document's body	covid:c94ef620e69c5b065486edee798854adb3c3d49b#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/c94ef620e69c5b065486edee798854adb3c3d49b
is schema:about of	named entity 'NTD' named entity 'domain' named entity 'protein' named entity 'COMPARED' named entity 'ALLOW' named entity 'PRESENTS' named entity 'IDENTIFIED' named entity 'CURATION' named entity 'DRAFT' named entity 'PROTEIN ' named entity 'ROLE' covid:arg/c94ef620e69c5b065486edee798854adb3c3d49b named entity 'Highlights' named entity 'loop' named entity 'Functional' named entity 'bind' named entity 'Title' named entity 'domain' named entity 'SARS-CoV' named entity 'N-terminal' named entity 'receptor' named entity 'spike protein' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity 'binding site' named entity 'infectivity' named entity 'RNA viruses' named entity 'genome' named entity 'cyclophilin' named entity 'severe acute respiratory syndrome coronavirus 2' named entity 'coronary heart disease' named entity 'SARS-CoV-2' named entity 'COVID' named entity 'cell adhesion molecule' named entity 'protein' named entity 'RMSD' named entity 'SARS-CoV-2' named entity 'U.S. National Library of Medicine' named entity 'Rossmann' named entity 'SARS-CoV' named entity 'coronavirus' named entity 'VCAM-1' named entity 'BCoV' named entity 'sugar' named entity 'angiotensin-converting enzyme 2' named entity 'red sticks' named entity 'C-terminal' named entity 'Mengo' named entity 'murine' named entity 'Protein Data Bank' named entity 'clove' named entity 'coronavirus' named entity '40%' named entity 'cyclophilin' named entity 'World Health Organization' named entity 'coronavirus' named entity 'virus' named entity 'MHV' named entity 'Shang' named entity 'ACE2' named entity 'prolyl isomerase' named entity 'protein' named entity 'ACE2 receptor' named entity 'viruses' named entity 'spike protein' named entity 'cyclophilin' named entity 'protein' named entity 'N-terminal' named entity 'asymmetric unit' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity 'viral particles' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity 'virions' named entity 'cytokines'

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