About: COVID-19 patients in a tertiary US hospital: Assessment of clinical course and predictors of the disease severity

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	COVID-19 patients in a tertiary US hospital: Assessment of clinical course and predictors of the disease severity
Creator	Wang, Chang Eng, Margaret Granet, Kenneth Mughal, Mohsin Patton, Chandler Sheraz, Mohsin Dalmacion, Denise Jaffery, Ali Kaur, Kaur, Preet Koyoda, Sai Kramer, Violet Weiner, Sharon
Source	Elsevier
abstract	Introduction Patients with severe COVID-19 can develop ventilator-dependent acute hypoxic respiratory failure (VDAHRF), which is associated with a higher mortality rate. We evaluated the clinical course of hospitalized COVID-19 patients and compared them with the patients who received invasive mechanical ventilation. Characteristics of intubated patients who were successfully weaned from the ventilator were compared with the patients who failed to be extubated or died in the hospital. Objective To investigate the clinical course of hospitalized COVID-19 patients, and assess the possible predictors of the disease severity leading to VDAHRF. Methods This is a single-center, retrospective study. The first 129 patients (18 years or older) with COVID-19 admitted to Monmouth Medical Center from March 1st to April 25th, 2020 were included. Results Out of 129 patients, 23.25% (n = 30) required invasive mechanical ventilation, and of those, six patients were successfully weaned from the ventilator. Multivariable logistic regression analysis showed increased odds of intubation associated with hypoxemia (odds ratio 17.23, 95% CI 5.206–57.088; p < 0.0001), elevated d-dimer by one unit mg/L of FEU (odds ratio 1.515, 95% CI 5.206–57.088; p = 0.0430) and elevated ferritin by one unit ng/ml (odds ratio 1.001, 95% CI 1.000–1.001, p = 0.0051) on admission, adjusted for other covariates. Conclusions Patients who required invasive mechanical ventilation were more likely to have older age, male gender, coronary artery disease, diabetes, and obesity. The patients who were successfully weaned from the ventilator were more likely to be younger in age, and none of them had heart failure or CAD.
has issue date	2020-08-28(xsd:dateTime)
bibo:doi	10.1016/j.rmed.2020.106130
has license	els-covid
sha1sum (hex)	c93e9ed22e538c716763739bc01b1a9d4c393ecf
schema:url	https://doi.org/10.1016/j.rmed.2020.106130
resource representing a document's title	COVID-19 patients in a tertiary US hospital: Assessment of clinical course and predictors of the disease severity
resource representing a document's body	covid:c93e9ed22e538c716763739bc01b1a9d4c393ecf#body_text
is schema:about of	named entity 'Patients' named entity 'coronary artery disease' named entity 'AGE' named entity 'ELEVATED FERRITIN' named entity 'UNIT' named entity 'diabetes' named entity 'odds ratio' named entity 'coronary artery disease' named entity 'Out' named entity 'FEU' named entity 'IQR' named entity 'hypoxemia' named entity 'regression analysis' named entity 'coronary artery disease' named entity 'heart failure' named entity 'odds ratio' named entity 'odds ratio' named entity 'median age' named entity 'COVID-19' named entity 'elevated' named entity 'ventilator' named entity 'inflammatory markers' named entity 'observational study' named entity 'ferritin' named entity 'lymphocyte count' named entity 'median age' named entity 'Multiple imputation' named entity 'PRVC' named entity 'hypertension' named entity 'Monmouth Medical Center' named entity 'COVID' named entity 'COVID' named entity 'D-dimer' named entity 'AKI' named entity 'modified early warning score' named entity 'sample size' named entity 'ventilator' named entity 'cytokine storm syndrome' named entity 'ARDS' named entity 'coronary artery disease' named entity 'Median age' named entity 'secondary infection' named entity 'invasive mechanical ventilation' named entity 'AKI' named entity 'oxygen' named entity 'ventilator' named entity 'dry cough' named entity 'Italy' named entity 'extubation' named entity 'Statistical analysis' named entity 'ferritin' named entity 'weaned' named entity 'pulmonary embolism' named entity 'oxygen' named entity 'inflammatory markers' named entity 'COVID' named entity 'institutional review board' named entity 'invasive mechanical ventilation' named entity 'ventilator' named entity 'septic shock' named entity 'weaned' named entity 'ferritin' named entity 'oxygen' named entity 'critically ill' named entity 'tracheostomy' named entity 'COVID' named entity 'AKI' named entity 'intubation' named entity 'regression analysis' named entity 'respiratory failure' named entity 'mortality rate' named entity 'weaned' named entity 'weaned'

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