About: Phage Displayed Peptides to Avian H5N1 Virus Distinguished the Virus from Other Viruses

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About: Phage Displayed Peptides to Avian H5N1 Virus Distinguished the Virus from Other Viruses Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Phage Displayed Peptides to Avian H5N1 Virus Distinguished the Virus from Other Viruses
Creator	Ren, Xiaofeng Digard, Paul Wu, Dan Qin, Chengfeng Li, Guangxing
Source	Medline; PMC
abstract	The purpose of the current study was to identify potential ligands and develop a novel diagnostic test to highly pathogenic avian influenza A virus (HPAI), subtype H5N1 viruses using phage display technology. The H5N1 viruses were used as an immobilized target in a biopanning process using a 12-mer phage display random peptide library. After five rounds of panning, three phages expressing peptides HAWDPIPARDPF, AAWHLIVALAPN or ATSHLHVRLPSK had a specific binding activity to H5N1 viruses were isolated. Putative binding motifs to H5N1 viruses were identified by DNA sequencing. In terms of the minimum quantity of viruses, the phage-based ELISA was better than antiserum-based ELISA and a manual, semi-quantitative endpoint RT-PCR for detecting H5N1 viruses. More importantly, the selected phages bearing the specific peptides to H5N1 viruses were capable of differentiating this virus from other avian viruses in enzyme-linked immunosorbent assays.
has issue date	2011-08-22(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0023058
bibo:pmid	21887228
has license	cc-by
sha1sum (hex)	c92d4b764634f984f72efccaa63b365bebc10616
schema:url	https://doi.org/10.1371/journal.pone.0023058
resource representing a document's title	Phage Displayed Peptides to Avian H5N1 Virus Distinguished the Virus from Other Viruses
has PubMed Central identifier	PMC3161733
has PubMed identifier	21887228
schema:publication	PLoS One
resource representing a document's body	covid:c92d4b764634f984f72efccaa63b365bebc10616#body_text
is schema:about of	named entity 'avian' named entity 'study' named entity 'technology' named entity 'motifs' named entity 'viruses' named entity 'immobilized' named entity 'Viruses' named entity 'VIRUSES' named entity 'DISPLAY TECHNOLOGY' named entity 'BEARING' named entity 'DIAGNOSTIC TEST' named entity 'BIOPANNING' named entity 'USED' named entity 'ROUNDS' named entity 'TERMS' named entity 'ENZYME-LINKED IMMUNOSORBENT ASSAYS' named entity 'TARGET' named entity 'ISOLATED' named entity 'RT-PCR' named entity 'BINDING ACTIVITY' named entity 'PEPTIDE LIBRARY' named entity 'VIRUS' named entity 'DIFFERENTIATING' named entity 'SPECIFIC' named entity 'RANDOM' named entity 'BETTER' named entity 'USING' named entity 'POTENTIAL' named entity 'AVIAN' named entity 'IDENTIFIED BY' named entity 'ENDPOINT' named entity 'HIGHLY PATHOGENIC AVIAN INFLUENZA' named entity 'MINIMUM' named entity 'DETECTING' named entity 'PROCESS' named entity 'A 12' named entity 'VIRUS' named entity 'BASED' named entity 'PHAGE' named entity 'PHAGE' named entity 'H5N1 VIRUS' named entity 'DISPLAYED' named entity 'AVIAN' named entity 'PEPTIDES' named entity 'CURRENT' named entity 'PURPOSE' named entity 'SELECTED' named entity 'PEPTIDES' named entity 'MANUAL' named entity 'SUBTYPE' named entity 'MOTIFS' named entity 'H5N1' named entity 'PHAGE DISPLAY' named entity 'ANTISERUM' named entity 'STUDY' named entity 'MER' named entity 'ELISA' named entity 'QUANTITY' named entity 'AVIAN INFLUENZA A VIRUS' named entity 'DNA SEQUENCING' named entity 'TO IDENTIFY' named entity 'NOVEL' named entity 'CAPABLE' named entity 'VIRUSES' named entity 'LIGANDS' named entity 'PHAGES ' named entity 'BINDING' covid:arg/c92d4b764634f984f72efccaa63b365bebc10616 named entity 'activity' named entity 'binding' named entity 'manual' named entity 'terms' named entity 'identify' named entity 'subtype' named entity 'quantity' named entity 'H5N1' named entity 'biopanning'

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