About: Identification of α-fodrin as an autoantigen in experimental coronavirus retinopathy (ECOR)

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About: Identification of α-fodrin as an autoantigen in experimental coronavirus retinopathy (ECOR) Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Identification of α-fodrin as an autoantigen in experimental coronavirus retinopathy (ECOR)
Creator	Detrick, Barbara Chin, Marian Hooks, John Hooper, Laura
Source	Elsevier; Medline; PMC
abstract	The coronavirus, mouse hepatitis virus (MHV), JHM strain induces a biphasic disease in BALB/c mice that consists of an acute retinitis followed by progression to a chronic retinal degeneration with autoimmune reactivity. Retinal degeneration resistant CD-1 mice do not develop either the late phase or autoimmune reactivity. A mouse RPE/choroid DNA expression library was screened using sera from virus infected BALB/c mice. Two clones were identified, villin-2 protein and α-fodrin protein. α-Fodrin protein was used for further analysis and western blot reactivity was seen only in sera from virus infected BALB/c mice. CD4 T cells were shown to specifically react with MHV antigens and with α-fodrin protein. These studies clearly identified both antibody and CD4 T cell reactivities to α-fodrin in sera from virus infected, retinal degenerative susceptible BALB/c mice.
has issue date	2014-07-15(xsd:dateTime)
bibo:doi	10.1016/j.jneuroim.2014.05.002
bibo:pmid	24864013
has license	no-cc
sha1sum (hex)	c927b8b0aa81aaab20b90c8725e8034116958314
schema:url	https://doi.org/10.1016/j.jneuroim.2014.05.002
resource representing a document's title	Identification of α-fodrin as an autoantigen in experimental coronavirus retinopathy (ECOR)
has PubMed Central identifier	PMC7112846
has PubMed identifier	24864013
schema:publication	J Neuroimmunol
resource representing a document's body	covid:c927b8b0aa81aaab20b90c8725e8034116958314#body_text
is schema:about of	named entity 'retinal degeneration' named entity 'choroid' named entity 'progression' named entity 'infected' named entity 'sera' named entity 'IDENTIFICATION' named entity 'EXPERIMENTAL' covid:arg/c927b8b0aa81aaab20b90c8725e8034116958314 named entity 'RETINOPATHY' named entity 'PROGRESSION' named entity 'ANTIBODY' named entity 'THESE' named entity 'CORONAVIRUS' named entity 'ANTIGENS' named entity 'CD-1' named entity 'MOUSE HEPATITIS VIRUS' named entity 'RETINITIS' named entity 'USED' named entity 'LATE PHASE' named entity 'VILLIN-2' named entity 'IDENTIFIED' named entity 'T CELL' named entity 'RPE' named entity 'STUDIES' named entity 'FODRIN' named entity 'WESTERN BLOT' named entity 'SUSCEPTIBLE' named entity 'SEEN' named entity 'AUTOANTIGEN' named entity 'STRAIN' named entity 'RETINAL' named entity 'DNA' named entity 'CHRONIC' named entity 'SERA' named entity 'RETINAL DEGENERATION' named entity 'A MOUSE' named entity 'FOLLOWED BY' named entity 'FODRIN' named entity 'CLONES' named entity 'PROTEIN' named entity 'ACUTE' named entity 'BALB' named entity 'REACTIVITY' named entity 'ANALYSIS' named entity 'RESISTANT' named entity 'CORONAVIRUS' named entity 'EXPRESSION LIBRARY' named entity 'EITHER' named entity 'BIPHASIC DISEASE' named entity 'USING' named entity 'VIRUS' named entity 'MICE' named entity 'DEGENERATIVE' named entity 'DO NOT' named entity 'REACT' named entity 'T CELLS' named entity 'INFECTED' named entity 'PROTEIN ' named entity 'CD4' named entity 'AUTOIMMUNE' named entity 'T cell' named entity 'Retinal degeneration' named entity 'protein' named entity 'library' named entity 'retinal degeneration' named entity 'protein' named entity 'autoimmune' named entity 'virus' named entity 'mice' named entity 'expression library' named entity 'virus' named entity 'mice' named entity 'BALB/c' named entity 'BALB/c' named entity 'mouse hepatitis virus' named entity 'antibody' named entity 'autoimmune' named entity 'mice'

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