About: Role of a fluid-phase PRR in fighting an intracellular pathogen: PTX3 in Shigella infection

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About: Role of a fluid-phase PRR in fighting an intracellular pathogen: PTX3 in Shigella infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Role of a fluid-phase PRR in fighting an intracellular pathogen: PTX3 in Shigella infection
Creator	Cohen, Dani Barbagallo, Marialuisa Bruno, Anna-Karin Ciancarella, Valeria Lembo-Fazio, Luigi Meron-Sudai, Shiri Molinaro, Antonio Bastien Jaillon, Sé Berardiid, Sara Bernardiniid, Maria Garlandaid, Cecilia Paciello Id, Rossiid, Giacomo
Source	PMC
abstract	Shigella spp. are pathogenic bacteria that cause bacillary dysentery in humans by invading the colonic and rectal mucosa where they induce dramatic inflammation. Here, we have analyzed the role of the soluble PRR Pentraxin 3 (PTX3), a key component of the humoral arm of innate immunity. Mice that had been intranasally infected with S. flexneri were rescued from death by treatment with recombinant PTX3. In vitro PTX3 exerts the antibacterial activity against Shigella, impairing epithelial cell invasion and contributing to the bactericidal activity of serum. PTX3 is produced upon LPS-TLR4 stimulation in accordance with the lipid A structure of Shigella. In the plasma of infected patients, the level of PTX3 amount only correlates strongly with symptom severity. These results signal PTX3 as a novel player in Shigella pathogenesis and its potential role in fighting shigellosis. Finally, we suggest that the plasma level of PTX3 in shigellosis patients could act as a biomarker for infection severity.
has issue date	2018-12-07(xsd:dateTime)
bibo:doi	10.1371/journal.ppat.1007469
bibo:pmid	30532257
has license	cc-by
sha1sum (hex)	c8a84384011fca6e1e24511d1b053eef4650fc04
schema:url	https://doi.org/10.1371/journal.ppat.1007469
resource representing a document's title	Role of a fluid-phase PRR in fighting an intracellular pathogen: PTX3 in Shigella infection
has PubMed Central identifier	PMC6317801
has PubMed identifier	30532257
schema:publication	PLoS Pathog
resource representing a document's body	covid:c8a84384011fca6e1e24511d1b053eef4650fc04#body_text
is schema:about of	named entity 'activity' named entity 'intracellular pathogen' covid:arg/c8a84384011fca6e1e24511d1b053eef4650fc04 named entity 'infected' named entity 'Mice' named entity 'key' named entity 'PTX3' named entity 'rectal mucosa' named entity 'antibacterial activity' named entity 'PTX3' named entity 'S. flexneri' named entity 'Shigella' named entity 'bacillary dysentery' named entity 'PTX3' named entity 'infection' named entity 'Here' named entity 'P. aeruginosa' named entity 'dendritic cells' named entity 'Università degli Studi di Milano-Bicocca' named entity 'PTX3' named entity 'Lungs' named entity 'PTX3' named entity 'lipid' named entity 'epithelial cells' named entity 'San Lazzaro' named entity 'Carros' named entity 'mice' named entity 'EDTA' named entity 'serum' named entity 'microbead' named entity 'PTX3' named entity 'Irf3' named entity 'Lonza' named entity 'Miltenyi Biotec' named entity 'T3SS' named entity 'biotinylated' named entity 'Mann-Whitney' named entity 'density gradient' named entity 'serum' named entity 'Shigella' named entity 'PTX3' named entity '8 days' named entity 'mice' named entity 'infection' named entity 'mice' named entity 'Shigella' named entity 'Italy' named entity 'infection' named entity 'TriF' named entity 'PTX3' named entity 'PTX3' named entity 'Secretion' named entity 'PTX3' named entity 'P. aeruginosa' named entity 'chemokine' named entity 'PTX3' named entity 'acylated' named entity 'supernatant' named entity 'lactate dehydrogenase' named entity 'TNF-α' named entity 'acylated' named entity 'mice' named entity 'Caco-2' named entity 'Shigella' named entity 'Shigella' named entity 'IL-1β' named entity 'TNF-α' named entity 'mice' named entity 'therapeutic approaches'

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