About: SARS-CoV-2 Entry Receptor ACE2 Is Expressed on Very Small CD45(−) Precursors of Hematopoietic and Endothelial Cells and in Response to Virus Spike Protein Activates the Nlrp3 Inflammasome

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About: SARS-CoV-2 Entry Receptor ACE2 Is Expressed on Very Small CD45(−) Precursors of Hematopoietic and Endothelial Cells and in Response to Virus Spike Protein Activates the Nlrp3 Inflammasome Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	SARS-CoV-2 Entry Receptor ACE2 Is Expressed on Very Small CD45(−) Precursors of Hematopoietic and Endothelial Cells and in Response to Virus Spike Protein Activates the Nlrp3 Inflammasome
Creator	Kucia, Magda Ratajczak, Mariusz Bujko, Kamila Ciechanowicz, Andrzej Cymer, Monika Marlicz, Wojciech Sielatycka, Kasia
source	Medline; PMC
abstract	Angiotensin-converting enzyme 2 (ACE2) plays an important role as a member of the renin–angiotensin–aldosterone system (RAAS) in regulating the conversion of angiotensin II (Ang II) into angiotensin (1–7) (Ang [1–7]). But at the same time, while expressed on the surface of human cells, ACE2 is the entry receptor for SARS-CoV-2. Expression of this receptor has been described in several types of cells, including hematopoietic stem cells (HSCs) and endothelial progenitor cells (EPCs), which raises a concern that the virus may infect and damage the stem cell compartment. We demonstrate for the first time that ACE2 and the entry-facilitating transmembrane protease TMPRSS2 are expressed on very small CD133(+)CD34(+)Lin(−)CD45(−) cells in human umbilical cord blood (UCB), which can be specified into functional HSCs and EPCs. The existence of these cells known as very small embryonic-like stem cells (VSELs) has been confirmed by several laboratories, and some of them may correspond to putative postnatal hemangioblasts. Moreover, we demonstrate for the first time that, in human VSELs and HSCs, the interaction of the ACE2 receptor with the SARS-CoV-2 spike protein activates the Nlrp3 inflammasome, which if hyperactivated may lead to cell death by pyroptosis. Based on this finding, there is a possibility that human VSELs residing in adult tissues could be damaged by SARS-CoV-2, with remote effects on tissue/organ regeneration. We also report that ACE2 is expressed on the surface of murine bone marrow-derived VSELs and HSCs, although it is known that murine cells are not infected by SARS-CoV-2. Finally, human and murine VSELs express several RAAS genes, which sheds new light on the role of these genes in the specification of early-development stem cells. [Figure: see text]
has issue date	2020-07-20(xsd:dateTime)
bibo:doi	10.1007/s12015-020-10010-z
bibo:pmid	32691370
has license	cc-by
sha1sum (hex)	c83c365eb064daec1ba261bf9ff4315b5e31af70
schema:url	https://doi.org/10.1007/s12015-020-10010-z
resource representing a document's title	SARS-CoV-2 Entry Receptor ACE2 Is Expressed on Very Small CD45(−) Precursors of Hematopoietic and Endothelial Cells and in Response to Virus Spike Protein Activates the Nlrp3 Inflammasome
has PubMed Central identifier	PMC7370872
has PubMed identifier	32691370
schema:publication	Stem Cell Rev Rep
resource representing a document's body	covid:c83c365eb064daec1ba261bf9ff4315b5e31af70#body_text
is schema:about of	named entity 'progenitor cells' named entity 'bone' named entity 'stem cells' named entity 'adult' named entity 'umbilical cord blood' named entity 'murine' named entity 'cells' named entity 'effects' named entity 'ACE2' named entity 'Nlrp3' named entity 'STEM CELLS' named entity 'KNOWN' named entity 'VIRUS' named entity 'EFFECTS' named entity 'DEVELOPMENT' named entity 'ACE2' named entity 'ROLE' named entity 'BUT' named entity 'RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM' named entity 'ACTIVATES' named entity 'RECEPTOR' named entity 'CD45' named entity 'HEMATOPOIETIC' named entity 'HSCs' named entity 'spike' named entity 'CD45' named entity 'HSCs' named entity 'expressed' named entity 'human' named entity 'hemangioblasts' named entity 'member' named entity 'expressed' named entity 'The' named entity 'tissues' named entity 'damage' named entity 'lead' named entity 'ACE2' named entity 'SARS-CoV-2' named entity 'angiotensin' named entity 'ACE2' named entity 'murine' named entity 'Nlrp3' named entity 'SARS-CoV-2' named entity 'HSCs' named entity 'SARS-CoV-2' named entity 'protease' named entity 'virus' named entity 'postnatal' named entity 'HSCs' named entity 'RAAS' named entity 'Ang II' named entity 'Inflammasome' named entity 'Nlrp3' named entity 'ACE2' named entity 'cells' named entity 'demonstrate' named entity 'receptor' named entity 'CD143' named entity 'viral proteins' named entity 'ACE2' named entity 'cell membranes' named entity 'skeletal muscle cells' named entity 'antibodies' named entity 'Sca-1' named entity 'SARS-CoV' named entity 'HSCs' named entity 'peptides' named entity 'ACE2 receptor' named entity 'immune response' named entity 'cardiomyocytes' named entity 'CD45' named entity 'ACE2' named entity 'Sca-1' named entity 'clone' named entity 'Miltenyi Biotec'

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