About: Replication in the Mononuclear Phagocyte System (MPS) as a Determinant of Hantavirus Pathogenicity

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About: Replication in the Mononuclear Phagocyte System (MPS) as a Determinant of Hantavirus Pathogenicity Goto Sponge NotDistinct Permalink

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Replication in the Mononuclear Phagocyte System (MPS) as a Determinant of Hantavirus Pathogenicity
Creator	Giese, Thomas Clement, Jan Belgium, Krüger, Detlev Leuven, K Ulrich, Rainer Song, Jin Aquino, Victor Kobak, Lidija Lalwani, Pritesh Lütteke, Nina Radosa, Lukas Raftery, Martin Schönrich, Günther
Source	PMC
abstract	Members of different virus families including Hantaviridae cause viral hemorrhagic fevers (VHFs). The decisive determinants of hantavirus-associated pathogenicity are still enigmatic. Pathogenic hantavirus species, such as Puumala virus (PUUV), Hantaan virus (HTNV), Dobrava-Belgrade virus (DOBV), and Sin Nombre virus (SNV), are associated with significant case fatality rates. In contrast, Tula virus (TULV) only sporadically causes mild disease in immunocompetent humans and Prospect Hill virus (PHV) so far has not been associated with any symptoms. They are thus defined here as low pathogenic/apathogenic hantavirus species. We found that productive infection of cells of the mononuclear phagocyte system (MPS), such as monocytes and dendritic cells (DCs), correlated well with the pathogenicity of hantavirus species tested. HTNV (intermediate case fatality rates) replicated more efficiently than PUUV (low case fatality rates) in myeloid cells, whereas low pathogenic/apathogenic hantavirus species did not produce any detectable virus titers. Analysis of PHPUV, a reassortant hantavirus derived from a pathogenic (PUUV) and an apathogenic (PHV) hantavirus species, indicated that the viral glycoproteins are not decisive for replication in MPS cells. Moreover, blocking acidification of endosomes with chloroquine decreased the number of TULV genomes in myeloid cells suggesting a post-entry block for low pathogenic/apathogenic hantavirus species in myeloid cells. Intriguingly, pathogenic but not low pathogenic/apathogenic hantavirus species induced conversion of monocytes into inflammatory DCs. The proinflammatory programming of MPS cells by pathogenic hantavirus species required integrin signaling and viral replication. Our findings indicate that the capacity to replicate in MPS cells is a prominent feature of hantaviral pathogenicity.
has issue date	2020-06-12(xsd:dateTime)
bibo:doi	10.3389/fcimb.2020.00281
has license	cc-by
sha1sum (hex)	c7de17c88a3507fc0da79ffcdc21a14219631bc3
schema:url	https://doi.org/10.3389/fcimb.2020.00281
resource representing a document's title	Replication in the Mononuclear Phagocyte System (MPS) as a Determinant of Hantavirus Pathogenicity
has PubMed Central identifier	PMC7304325
schema:publication	Front Cell Infect Microbiol
resource representing a document's body	covid:c7de17c88a3507fc0da79ffcdc21a14219631bc3#body_text
is schema:about of	named entity 'cells' named entity 'symptoms' named entity 'fatality' named entity 'virus' named entity 'determinants' named entity 'MPS' named entity 'contrast' named entity 'hantavirus' named entity 'correlated' named entity 'Our' named entity 'Hantavirus' named entity 'MPS' named entity 'DENDRITIC CELLS' named entity 'FINDINGS' named entity 'DERIVED' named entity 'MPS' named entity 'HUMANS' named entity 'BLOCK' named entity 'FAR' named entity 'CAUSES' named entity 'ACIDIFICATION' named entity 'DECREASED' named entity 'OUR' named entity 'CONVERSION' named entity 'LOW' named entity 'GENOMES' named entity 'FEATURE' named entity 'DCs' named entity 'species' named entity 'pathogenic' named entity 'cells' named entity 'pathogenic' named entity 'MPS' named entity 'myeloid' named entity 'integrin' named entity 'Sin Nombre virus' named entity 'acidification' named entity 'species' named entity 'endosomes' named entity 'MPS' named entity 'signaling' named entity 'Analysis' named entity 'pathogenicity' named entity 'Hantaan' named entity 'Determinant' named entity 'Puumala' named entity 'myeloid cells' named entity 'monocytes' named entity 'hantavirus' named entity 'genomes' named entity 'Prospect Hill virus' named entity 'viral hemorrhagic fevers' named entity 'Dobrava-Belgrade virus' named entity 'inflammatory' named entity 'hantavirus' named entity 'case fatality rates' named entity 'pathogenicity' named entity 'DCs' named entity 'infection' named entity 'dendritic cells' named entity 'SNV' named entity 'immunocompetent' named entity 'Pathogenicity' named entity 'Mononuclear Phagocyte' named entity 'PBMCs' named entity 'MHC class II' named entity 'pathogenicity' named entity 'Dobrava-Belgrade virus' named entity 'monocyte' named entity 'Vero E6'

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