About: The Role of Na/K-ATPase Signaling in Oxidative Stress Related to Obesity and Cardiovascular Disease

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The Role of Na/K-ATPase Signaling in Oxidative Stress Related to Obesity and Cardiovascular Disease
Creator	Sodhi, Komal Srikanthan, Krithika Shapiro, Joseph
Source	PMC
abstract	Na/K-ATPase has been extensively studied for its ion pumping function, but, in the past several decades, has been identified as a scaffolding and signaling protein. Initially it was found that cardiotonic steroids (CTS) mediate signal transduction through the Na/K-ATPase and result in the generation of reactive oxygen species (ROS), which are also capable of initiating the signal cascade. However, in recent years, this Na/K-ATPase/ROS amplification loop has demonstrated significance in oxidative stress related disease states, including obesity, atherosclerosis, heart failure, uremic cardiomyopathy, and hypertension. The discovery of this novel oxidative stress signaling pathway, holds significant therapeutic potential for the aforementioned conditions and others that are rooted in ROS.
has issue date	2016-09-03(xsd:dateTime)
bibo:doi	10.3390/molecules21091172
bibo:pmid	27598118
has license	cc-by
sha1sum (hex)	c7d6dd30a24a63898307d3d9e1dd6ca13a6cf9bd
schema:url	https://doi.org/10.3390/molecules21091172
resource representing a document's title	The Role of Na/K-ATPase Signaling in Oxidative Stress Related to Obesity and Cardiovascular Disease
has PubMed Central identifier	PMC5642908
has PubMed identifier	27598118
schema:publication	Molecules
resource representing a document's body	covid:c7d6dd30a24a63898307d3d9e1dd6ca13a6cf9bd#body_text
is schema:about of	named entity 'function' named entity 'mediate' named entity 'However' named entity 'rooted' named entity 'The' named entity 'Stress' named entity 'ATPASE' named entity 'NOVEL' named entity 'STRESS SIGNALING PATHWAY' named entity 'CARDIOTONIC STEROIDS' named entity 'IDENTIFIED' named entity 'HYPERTENSION' named entity 'INCLUDING' named entity 'THERAPEUTIC' named entity 'INITIALLY' named entity 'RESULT' named entity 'DISEASE' named entity 'RELATED' named entity 'CAPABLE' named entity 'IN THE PAST' named entity 'SCAFFOLDING' named entity 'REACTIVE OXYGEN SPECIES' named entity 'ROS' named entity 'SIGNIFICANCE' named entity 'ATPASE' named entity 'OXIDATIVE STRESS' named entity 'SIGNALING PROTEIN' named entity 'SIGNAL' named entity 'SIGNAL TRANSDUCTION' named entity 'BUT' named entity 'CONDITIONS' named entity 'SIGNIFICANT' named entity 'CASCADE' named entity 'ION' named entity 'STATES' named entity 'FOUND' named entity 'SIGNALING' named entity 'ROLE' named entity 'GENERATION' named entity 'OBESITY' named entity 'RELATED' named entity 'CARDIOVASCULAR DISEASE' named entity 'PUMPING FUNCTION' named entity 'ATHEROSCLEROSIS' named entity 'ITS' named entity 'POTENTIAL' named entity 'DISCOVERY' named entity 'OBESITY' named entity 'LOOP' named entity 'ROOTED' named entity 'CARDIOMYOPATHY' named entity 'HEART FAILURE' named entity 'INITIATING' named entity 'YEARS' named entity 'MOLECULES' named entity 'OXIDATIVE STRESS' named entity 'MEDIATE' named entity 'RECENT' named entity 'AMPLIFICATION' covid:arg/c7d6dd30a24a63898307d3d9e1dd6ca13a6cf9bd named entity 'oxidative stress' named entity 'Cardiovascular Disease' named entity 'oxidative stress' named entity 'atherosclerosis' named entity 'signaling protein' named entity 'ion' named entity 'Na/K-ATPase' named entity 'signaling pathway' named entity 'Obesity' named entity 'Oxidative Stress' named entity 'Na/K-ATPase' named entity 'ROS' named entity 'Src' named entity 'Src family kinase' named entity 'heart failure' named entity 'adipocytes' named entity 'chronic kidney disease' named entity 'oxidative stress' named entity 'negative regulator'

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