About: Private specificities of CD8 T cell responses control patterns of heterologous immunity

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Private specificities of CD8 T cell responses control patterns of heterologous immunity
Creator	Cornberg, Markus Kim, Sung-Kwon Chen, Hong Selin, Liisa Welsh, Raymond Wang, Xiaoting
Source	Medline; PMC
abstract	CD8 T cell cross-reactivity between viruses can play roles in protective heterologous immunity and damaging immunopathology. This cross-reactivity is sometimes predictable, such as between lymphocytic choriomeningitis virus (LCMV) and Pichinde virus, where cross-reactive epitopes share six out of eight amino acids. Here, however, we demonstrate more subtle and less predictable cross-reactivity between LCMV and the unrelated vaccinia virus (VV). Epitope-specific T cell receptor usage differed between individual LCMV-infected C57BL/6 mice, even though the mice had similar epitope-specific T cell hierarchies. LCMV-immune mice challenged with VV showed variations, albeit in a distinct hierarchy, in proliferative expansions of and down-regulation of IL-7Rα by T cells specific to different LCMV epitopes. T cell responses to a VV-encoded epitope that is cross-reactive with LCMV fluctuated greatly in VV-infected LCMV-immune mice. Adoptive transfers of splenocytes from individual LCMV-immune donors resulted in nearly identical VV-induced responses in each of several recipients, but responses differed depending on the donor. This indicates that the specificities of T cell responses that are not shared between individuals may influence cross-reactivity with other antigens and play roles in heterologous immunity upon encounter with another pathogen. This variability in cross-reactive T cell expansion that is unique to the individual may underlie variation in the pathogenesis of infectious diseases.
has issue date	2005-02-21(xsd:dateTime)
bibo:doi	10.1084/jem.20041337
bibo:pmid	15710651
has license	cc-by-nc-sa
sha1sum (hex)	c761570812ca07ce01397ebabc220556f51e786e
schema:url	https://doi.org/10.1084/jem.20041337
resource representing a document's title	Private specificities of CD8 T cell responses control patterns of heterologous immunity
has PubMed Central identifier	PMC2213046
has PubMed identifier	15710651
schema:publication	J Exp Med
resource representing a document's body	covid:c761570812ca07ce01397ebabc220556f51e786e#body_text
is schema:about of	named entity 'PRIVATE' covid:arg/c761570812ca07ce01397ebabc220556f51e786e named entity 'IMMUNITY' named entity 'RESPONSES' named entity 'UNRELATED' named entity 'EPITOPES' named entity 'SHARE' named entity 'SPECIFIC' named entity 'IMMUNITY' named entity 'T CELL RECEPTOR' named entity 'HIERARCHIES' named entity 'VACCINIA VIRUS' named entity 'HETEROLOGOUS' named entity 'T CELL' named entity 'CONTROL' named entity 'PATTERNS' named entity 'CD8' named entity 'WHERE' named entity 'IMMUNOPATHOLOGY' named entity 'CD8' named entity 'USAGE' named entity 'VIRUSES' named entity 'PICHINDE VIRUS' named entity 'LCMV' named entity 'EPITOPE' named entity 'AMINO ACIDS' named entity 'INFECTED' named entity 'CROSS' named entity 'DAMAGING' named entity 'SPECIFICITIES' named entity 'SIMILAR' named entity 'C57BL' named entity 'LYMPHOCYTIC CHORIOMENINGITIS VIRUS' named entity 'MICE' named entity 'PLAY ROLES' named entity 'HETEROLOGOUS' named entity 'REACTIVITY' named entity 'INDIVIDUAL' named entity 'T CELL' named entity 'HERE' named entity 'Epitope' named entity 'CD8 T cell' named entity 'cross-reactivity' named entity 'LCMV' named entity 'viruses' named entity 'LCMV' named entity 'cross-reactivity' named entity 'mice' named entity 'mice' named entity 'epitope' named entity 'CD8' named entity 'peptide' named entity 'immune cells' named entity 'mice' named entity 'MHC' named entity 'infection' named entity 'CD8 T cells' named entity 'MHC' named entity 'CD8 T cells' named entity 'viruses' named entity 'mice' named entity 'fluorescently' named entity 'clones' named entity 'epitope' named entity 'LCMV' named entity 'cross-reactive' named entity 'epitope' named entity 'assay' named entity 'HBBS' named entity 'LCMV' named entity 'dengue' named entity 'Flow cytometry' named entity 'PerkinElmer' named entity 'incubation' named entity 'host response' named entity 'epitope'

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