About: Growth restriction of an experimental live attenuated human parainfluenza virus type 2 vaccine in human ciliated airway epithelium in vitro parallels attenuation in African green monkeys

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About: Growth restriction of an experimental live attenuated human parainfluenza virus type 2 vaccine in human ciliated airway epithelium in vitro parallels attenuation in African green monkeys Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Growth restriction of an experimental live attenuated human parainfluenza virus type 2 vaccine in human ciliated airway epithelium in vitro parallels attenuation in African green monkeys
Creator	Pickles, Raymond Murphy, Brian Schaap-Nutt, Anne Schmidt, Alexander Scull, Margaret
Source	Elsevier; Medline; PMC
abstract	Human parainfluenza viruses (HPIVs) are common causes of severe pediatric respiratory viral disease. We characterized wild-type HPIV2 infection in an in vitro model of human airway epithelium (HAE) and found that the virus replicates to high titer, sheds apically, targets ciliated cells, and induces minimal cytopathology. Replication of an experimental, live attenuated HPIV2 vaccine strain, containing both temperature sensitive (ts) and non-ts attenuating mutations, was restricted >30-fold compared to rHPIV2-WT in HAE at 32°C and exhibited little productive replication at 37°C. This restriction paralleled attenuation in the upper and lower respiratory tract of African green monkeys, supporting the HAE model as an appropriate and convenient system for characterizing HPIV2 vaccine candidates.
has issue date	2010-03-01(xsd:dateTime)
bibo:doi	10.1016/j.vaccine.2010.01.050
bibo:pmid	20139039
has license	green-oa
sha1sum (hex)	c7482fd487c4a1a40e25b393ba04466922d434b1
schema:url	https://doi.org/10.1016/j.vaccine.2010.01.050
resource representing a document's title	Growth restriction of an experimental live attenuated human parainfluenza virus type 2 vaccine in human ciliated airway epithelium in vitro parallels attenuation in African green monkeys
has PubMed Central identifier	PMC2844349
has PubMed identifier	20139039
schema:publication	Vaccine
resource representing a document's body	covid:c7482fd487c4a1a40e25b393ba04466922d434b1#body_text
is schema:about of	named entity 'AIRWAY EPITHELIUM' named entity 'HUMAN PARAINFLUENZA VIRUS TYPE 2' named entity 'EXPERIMENTAL' named entity 'titer' named entity 'experimental' named entity 'parainfluenza virus' named entity 'live attenuated' named entity 'Growth' named entity 'NON-' named entity 'LITTLE' named entity 'APPROPRIATE' named entity 'LOWER RESPIRATORY TRACT' named entity 'REPLICATES' named entity 'CONTAINING' named entity 'SEVERE' named entity 'CYTOPATHOLOGY' named entity 'CILIATED CELLS' named entity 'RESTRICTION' named entity 'MODEL' named entity 'AIRWAY EPITHELIUM' named entity 'CONVENIENT' named entity 'REPLICATION' named entity 'AFRICAN GREEN MONKEYS' named entity 'ATTENUATION' named entity 'ATTENUATION' named entity 'MINIMAL' named entity 'CILIATED' named entity 'AFRICAN GREEN MONKEYS' named entity 'TITER' named entity 'VIRAL DISEASE' named entity 'COMPARED' named entity 'HUMAN' named entity 'ATTENUATED' named entity 'LIVE' named entity 'IN VITRO' named entity 'SUPPORTING' named entity 'CHARACTERIZED' named entity 'FOLD' named entity 'MUTATIONS' named entity 'LIVE' named entity 'VACCINE' named entity 'TARGETS' named entity 'RESTRICTED' named entity 'HUMAN PARAINFLUENZA VIRUSES' named entity 'UPPER' named entity 'RESPIRATORY' named entity 'CAUSES' named entity 'GROWTH RESTRICTION' named entity 'VACCINE STRAIN' named entity 'HIGH' named entity 'VIRUS' named entity 'VACCINE' named entity 'PEDIATRIC' named entity 'WILD-TYPE' named entity 'MODEL OF' named entity 'COMMON' named entity 'IN VITRO MODEL' named entity 'PRODUCTIVE' named entity 'HUMAN' named entity 'ATTENUATED' named entity 'TEMPERATURE SENSITIVE' named entity 'SYSTEM' named entity 'HAE' named entity 'FOUND' named entity 'INFECTION' named entity 'EXPERIMENTAL' covid:arg/c7482fd487c4a1a40e25b393ba04466922d434b1 named entity 'infection' named entity 'pediatric' named entity 'model' named entity 'productive' named entity 'severe' named entity 'replicates' named entity 'respiratory' named entity 'wild-type' named entity 'live attenuated' named entity 'vaccine strain'

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