About: Immunophenotyping of COVID-19 and influenza highlights the role of type I interferons in development of severe COVID-19

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About: Immunophenotyping of COVID-19 and influenza highlights the role of type I interferons in development of severe COVID-19 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Immunophenotyping of COVID-19 and influenza highlights the role of type I interferons in development of severe COVID-19
Creator	Kim, Sung-Han Shin, Eui-Cheol Kwon, Ji-Soo Ahn, Jin Choi, Jun Jeong, Hye Jeong, Su Lee, Heung Lee, Jeong Park, Sung Choi, Choi, Baekgyu Jung, Inkyung Lee, Hoyoung Nam, Su Park, Seongwan Park, Su-Hyung Sa, Moa Seong, Jin
Source	Medline; PMC
abstract	Although most SARS-CoV-2-infected individuals experience mild coronavirus disease 2019 (COVID-19), some patients suffer from severe COVID-19, which is accompanied by acute respiratory distress syndrome and systemic inflammation. To identify factors driving severe progression of COVID-19, we performed single-cell RNA-seq using peripheral blood mononuclear cells (PBMCs) obtained from healthy donors, patients with mild or severe COVID-19, and patients with severe influenza. Patients with COVID-19 exhibited hyper-inflammatory signatures across all types of cells among PBMCs, particularly up-regulation of the TNF/IL-1β-driven inflammatory response as compared to severe influenza. In classical monocytes from patients with severe COVID-19, type I IFN response co-existed with the TNF/IL-1β-driven inflammation, and this was not seen in patients with milder COVID-19. Interestingly, we documented type I IFN-driven inflammatory features in patients with severe influenza as well. Based on this, we propose that the type I IFN response plays a pivotal role in exacerbating inflammation in severe COVID-19.
has issue date	2020-07-10(xsd:dateTime)
bibo:doi	10.1126/sciimmunol.abd1554
bibo:pmid	32651212
has license	cc-by
sha1sum (hex)	c718ef0cd868b60f5e7cd2d63043f69248efaccc
schema:url	https://doi.org/10.1126/sciimmunol.abd1554
resource representing a document's title	Immunophenotyping of COVID-19 and influenza highlights the role of type I interferons in development of severe COVID-19
has PubMed Central identifier	PMC7402635
has PubMed identifier	32651212
schema:publication	Sci Immunol
resource representing a document's body	covid:c718ef0cd868b60f5e7cd2d63043f69248efaccc#body_text
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