About: Serum Amyloid A Protein Concentration in Blood is Influenced by Genetic Differences in the Cheetah (Acinonyx jubatus)

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About: Serum Amyloid A Protein Concentration in Blood is Influenced by Genetic Differences in the Cheetah (Acinonyx jubatus) Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Serum Amyloid A Protein Concentration in Blood is Influenced by Genetic Differences in the Cheetah (Acinonyx jubatus)
Creator	Marker, Laurie Schmidt-Küntzel, Anne Terio, Karen Crosier, Adrienne Franklin, Ashley
source	PMC
abstract	Systemic amyloid A (AA) amyloidosis is a major cause of morbidity and mortality among captive cheetahs. The self-aggregating AA protein responsible for this disease is a byproduct of serum amyloid A (SAA) protein degradation. Transcriptional induction of the SAA1 gene is dependent on both C/EBPβ and NF-κB cis-acting elements within the promoter region. In cheetahs, 2 alleles exist for a single guanine nucleotide deletion in the putative NF-κB binding site. In this study, a novel genotyping assay was developed to screen for the alleles. The results show that the SAA1A(−97delG) allele is associated with decreased SAA protein concentrations in the serum of captive cheetahs (n = 58), suggesting genetic differences at this locus may be affecting AA amyloidosis prevalence. However, there was no significant difference in the frequency of the SAA1A(−97delG) allele between individuals confirmed AA amyloidosis positive versus AA amyloidosis negative at the time of necropsy (n = 48). Thus, even though there is evidence that having more copies of the SAA1A(−97delG) allele results in a potentially protective decrease in serum concentrations of SAA protein in captive cheetahs, genotype is not associated with this disease within the North American population. These results suggest that other factors are playing a more significant role in the pathogenesis of AA amyloidosis among captive cheetahs.
has issue date	2015-11-19(xsd:dateTime)
bibo:doi	10.1093/jhered/esv089
bibo:pmid	26585380
has license	bronze-oa
sha1sum (hex)	c6a4e5bb096c02107ee35adeda5d0b0137514ca7
schema:url	https://doi.org/10.1093/jhered/esv089
resource representing a document's title	Serum Amyloid A Protein Concentration in Blood is Influenced by Genetic Differences in the Cheetah (Acinonyx jubatus)
has PubMed Central identifier	PMC5994965
has PubMed identifier	26585380
schema:publication	Journal of Heredity
resource representing a document's body	covid:c6a4e5bb096c02107ee35adeda5d0b0137514ca7#body_text
is schema:about of	named entity 'pathogenesis' named entity 'assay' named entity 'serum' named entity 'North American' named entity 'allele' named entity 'induction' named entity 'PROMOTER' named entity 'NEGATIVE' named entity 'IS A' named entity 'AMYLOIDOSIS' named entity 'COPIES' named entity 'SCREEN' named entity 'PROTEIN DEGRADATION' named entity 'DIFFERENCE' named entity 'CIS' named entity 'A MAJOR' named entity 'ROLE' named entity 'SELF' named entity 'ALLELE' named entity 'LOCUS' named entity 'IN BLOOD' named entity 'PROTEIN CONCENTRATION' named entity 'SERUM AMYLOID A PROTEIN' named entity 'MORBIDITY AND MORTALITY' named entity 'FREQUENCY' named entity 'GENETIC' named entity 'CHEETAH' named entity 'DEPENDENT' named entity 'RESPONSIBLE' named entity 'NUCLEOTIDE DELETION' named entity 'AA PROTEIN' named entity 'SERUM' named entity 'ALLELES' named entity 'GENOTYPE' named entity 'SINGLE' named entity 'PREVALENCE' named entity 'GENETIC' named entity 'CAUSE' named entity 'CONFIRMED' named entity 'PLAYING' named entity 'CHEETAHS' named entity 'POSITIVE' named entity 'ASSOCIATED WITH' named entity 'SIGNIFICANT' named entity 'SUGGEST' named entity 'AA AMYLOIDOSIS' named entity 'SAA1' named entity 'PROTEIN ' named entity 'DISEASE' named entity 'AGGREGATING' named entity 'SYSTEMIC' named entity 'PATHOGENESIS' named entity 'NORTH AMERICAN' named entity 'MAY BE' named entity 'DECREASED' named entity 'EXIST' named entity 'TIME' named entity 'RESULTS' named entity 'CONCENTRATIONS' named entity 'DECREASE' named entity 'GENOTYPING ASSAY' named entity 'POPULATION' named entity 'GENE' named entity 'BINDING SITE' named entity 'GUANINE NUCLEOTIDE' named entity 'TRANSCRIPTIONAL INDUCTION' named entity 'NOVEL' named entity 'AFFECTING' named entity 'SAA' named entity 'SERUM AMYLOID A' named entity 'THESE' named entity 'BAB' named entity 'NECROPSY' named entity 'AMYLOID A' named entity 'ELEMENTS' named entity 'INDIVIDUALS' named entity 'REGION'

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