About: Glycyrrhizic‐Acid‐Based Carbon Dots with High Antiviral Activity by Multisite Inhibition Mechanisms

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About: Glycyrrhizic‐Acid‐Based Carbon Dots with High Antiviral Activity by Multisite Inhibition Mechanisms Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Glycyrrhizic‐Acid‐Based Carbon Dots with High Antiviral Activity by Multisite Inhibition Mechanisms
Creator	Fang, Liurong Xiao, Shaobo Tong, T Zhang, X Zhou, Junwei Zhou, J Deng, S Tang, W Xiao, Fang, Liang, Deng, Shuangfei Hu, H Hu, Hongwei Liang, Jiangong Tang, Wantao Tong, Ting Zhang, Xiaotong
Source	Medline; PMC
abstract	With the gradual usage of carbon dots (CDs) in the area of antiviral research, attempts have been stepped up to develop new antiviral CDs with high biocompatibility and antiviral effects. In this study, a kind of highly biocompatible CDs (Gly‐CDs) is synthesized from active ingredient (glycyrrhizic acid) of Chinese herbal medicine by a hydrothermal method. Using the porcine reproductive and respiratory syndrome virus (PRRSV) as a model, it is found that the Gly‐CDs inhibit PRRSV proliferation by up to 5 orders of viral titers. Detailed investigations reveal that Gly‐CDs can inhibit PRRSV invasion and replication, stimulate antiviral innate immune responses, and inhibit the accumulation of intracellular reactive oxygen species (ROS) caused by PRRSV infection. Proteomics analysis demonstrates that Gly‐CDs can stimulate cells to regulate the expression of some host restriction factors, including DDX53 and NOS3, which are directly related to PRRSV proliferation. Moreover, it is found that Gly‐CDs also remarkably suppress the propagation of other viruses, such as pseudorabies virus (PRV) and porcine epidemic diarrhea virus (PEDV), suggesting the broad antiviral activity of Gly‐CDs. The integrated results demonstrate that Gly‐CDs possess extraordinary antiviral activity with multisite inhibition mechanisms, providing a promising candidate for alternative therapy for PRRSV infection.
has issue date	2020-02-20(xsd:dateTime)
bibo:doi	10.1002/smll.201906206
bibo:pmid	32077621
has license	no-cc
sha1sum (hex)	c6684552e6df800e8e481903ea5c7a7980058b88
schema:url	https://doi.org/10.1002/smll.201906206
resource representing a document's title	Glycyrrhizic‐Acid‐Based Carbon Dots with High Antiviral Activity by Multisite Inhibition Mechanisms
has PubMed Central identifier	PMC7169479
has PubMed identifier	32077621
schema:publication	Small
resource representing a document's body	covid:c6684552e6df800e8e481903ea5c7a7980058b88#body_text
is schema:about of	named entity 'glycyrrhizic acid' named entity '0.45' named entity 'pig' named entity 'PRV' named entity 'Viruses' named entity 'antiviral' named entity 'carbon quantum dots' named entity 'protein expression' named entity 'interferon' named entity 'proteomic analysis' named entity 'isoforms' named entity 'hpi' named entity 'water solubility' named entity 'cardiovascular diseases' named entity 'functional groups' named entity 'citric acid' named entity 'Gly' named entity 'Chinese herbal medicine' named entity 'photodynamic therapy' named entity 'DDX53' named entity 'virus' named entity 'protein' named entity 'Proteomic Analysis' named entity 'Antiviral' named entity 'recombinant' named entity 'cardiomyocyte' named entity 'Western blot' named entity 'nuclei' named entity 'isobaric tag' named entity 'Vero cells' named entity 'aniline' named entity 'oxygen' named entity 'proteomic analysis' named entity 'Gly' named entity 'anti-inflammation' named entity 'Gly' named entity 'DMEM' named entity 'significant difference' named entity 'viral replication' named entity 'antiviral' named entity 'experimental group' named entity 'glycyrrhizic acid' named entity 'Gly' named entity 'fluorescence spectrum' named entity 'glycyrrhizic acid' named entity 'β-adrenergic' named entity 'inoculum' named entity 'Reactive oxygen species' named entity 'cellular immune' named entity 'positive control' named entity 'immunoregulation' named entity 'dispersibility' named entity 'virus' named entity 'antiviral' named entity 'influenza A virus' named entity 'adsorption' named entity 'DNA viruses' named entity 'glycyrrhizic acid' named entity 'fluorescence' named entity 'carbon' named entity 'Gly' named entity 'freeze-dried' named entity 'carbon' named entity '37 °C'

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