About: Association of history of cerebrovascular disease with severity of COVID-19

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Association of history of cerebrovascular disease with severity of COVID-19
Creator	Bornstein, Stefan Barlinn, Kristian Barlinn, Jessica Koch, Thea Pallesen, Lars-Peder Sedghi, Annahita Siepmann, Timo Gruenewald, Thomas Gueldner, Andreas Helbig, Sina Schubert, Joerg Haidar Moustafa, · Katja De With, · Lutz Mirow, · Martin Wolz, · Reichmann, · Rosengarten, · Schroettner, · Simon Winzer, · Simone Von Bonin, · Spieth, · Volker Puetz, ·
Source	Medline; PMC
abstract	OBJECTIVE: To determine whether a history of cerebrovascular disease (CVD) increases risk of severe coronavirus disease 2019 (COVID-19). METHODS: In a retrospective multicenter study, we retrieved individual data from in-patients treated March 1 to April 15, 2020 from COVID-19 registries of three hospitals in Saxony, Germany. We also performed a systematic review and meta-analysis following PRISMA recommendations using PubMed, EMBASE, Cochrane Library databases and bibliographies of identified papers (last search on April 11, 2020) and pooled data with those deriving from our multicenter study. Of 3762 records identified, 11 eligible observational studies of laboratory-confirmed COVID-19 patients were included in quantitative data synthesis. Risk ratios (RR) of severe COVID-19 according to history of CVD were pooled using DerSimonian and Laird random effects model. Between-study heterogeneity was assessed using Cochran’s Q and I2-statistics. Severity of COVID-19 according to definitions applied in included studies was the main outcome. Sensitivity analyses were conducted for clusters of studies with equal definitions of severity. RESULTS: Pooled analysis included data from 1906 laboratory-confirmed COVID-19 patients (43.9% females, median age ranging from 39 to 76 years). Patients with previous CVD had higher risk of severe COVID-19 than those without [RR 2.07, 95% confidence interval (CI) 1.52–2.81; p < 0.0001]. This association was also observed in clusters of studies that defined severe manifestation of the disease by clinical parameters (RR 1.44, 95% CI 1.22–1.71; p < 0.0001), necessity of intensive care (RR 2.79, 95% CI 1.83–4.24; p < 0.0001) and in-hospital death (RR 2.18, 95% CI 1.75–2.7; p < 0.0001). CONCLUSION: A history of CVD might constitute an important risk factor of unfavorable clinical course of COVID-19 suggesting a need of tailored infection prevention and clinical management strategies for this population at risk. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00415-020-10121-0) contains supplementary material, which is available to authorized users.
has issue date	2020-08-06(xsd:dateTime)
bibo:doi	10.1007/s00415-020-10121-0
bibo:pmid	32761508
has license	cc-by
sha1sum (hex)	c65dd9626285e3f147eba0108426ee40a017cb06
schema:url	https://doi.org/10.1007/s00415-020-10121-0
resource representing a document's title	Association of history of cerebrovascular disease with severity of COVID-19
has PubMed Central identifier	PMC7407424
has PubMed identifier	32761508
schema:publication	J Neurol
resource representing a document's body	covid:c65dd9626285e3f147eba0108426ee40a017cb06#body_text
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