About: Molecular Mimicry, Microbial Infection, and Autoimmune Disease: Evolution of the Concept

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Molecular Mimicry, Microbial Infection, and Autoimmune Disease: Evolution of the Concept
Creator	Oldstone, M
Source	Medline; PMC
abstract	Molecular mimicry is defined as similar structures shared by molecules from dissimilar genes or by their protein products. Either several linear amino acids or their conformational fit may be shared, even though their origins are separate. Hence, during a viral or microbe infection, if that organism shares cross-reactive epitopes for B or T cells with the host, then the response to the infecting agent will also attack the host, causing autoimmune disease. A variation on this theme is when a second, third, or repeated infection(s) shares cross-reactive B or T cell epitopes with the first (initiating) virus but not necessarily the host. In this instance, the secondary infectious agents increase the number of antiviral/antihost effector antibodies or T cells that potentiate or precipitate the autoimmune assault. The formation of this concept initially via study of monoclonal antibody or clone T cell cross-recognition in vitro through its evolution to in vivo animal models and to selected human diseases is explored in this mini-review.
has issue date	2005-01-01(xsd:dateTime)
bibo:doi	10.1007/3-540-30791-5_1
bibo:pmid	16329189
has license	no-cc
sha1sum (hex)	c5806ec68ef524f362779ff78c997568b1359051
schema:url	https://doi.org/10.1007/3-540-30791-5_1
resource representing a document's title	Molecular Mimicry, Microbial Infection, and Autoimmune Disease: Evolution of the Concept
has PubMed Central identifier	PMC7120699
has PubMed identifier	16329189
schema:publication	Molecular Mimicry: Infection-Inducing Autoimmune Disease
resource representing a document's body	covid:c5806ec68ef524f362779ff78c997568b1359051#body_text
is schema:about of	named entity 'Concept' named entity 'Autoimmune Disease' named entity 'Microbial' named entity 'hemagglutinin' named entity 'Guillain-Barré' named entity 'ankylosing spondylitis' named entity 'vimentin' named entity 'NZB' named entity 'EAE' named entity 'perforin' named entity 'streptococcus' named entity 'virus' named entity 'inoculated' named entity 'peptide' named entity 'AChR' named entity 'myelin basic protein' named entity 'IDDM' named entity 'MHC' named entity 'HLA B27' named entity 'clonal anergy' named entity 'cross-reacts' named entity 'autoimmune diseases' named entity 'immune complex' named entity 'immunologist' named entity 'virus' named entity 'coronaviruses' named entity 'myasthenia gravis' named entity 'diabetes' named entity 'humoral' named entity 'clonal deletion' named entity 'bacteriologic' named entity 'molecular mimicry' named entity 'multiple sclerosis' named entity 'EAE' named entity 'immune response' named entity 'microbial' named entity 'inside cells' named entity 'parasites' named entity 'autoimmune disorders' named entity 'herpes simplex virus' named entity 'transgenic mice' named entity 'immunologic tolerance' named entity 'antibodies' named entity 'immune attack' named entity 'RNA viruses' named entity 'Shigella' named entity 'genetics' named entity 'cell receptor' named entity 'virus' named entity 'mice' named entity 'microbes' named entity 'polyclonal antibody' named entity 'self-antigens' named entity 'cell recognition' named entity 'cell receptor' named entity 'Shigella flexneri' named entity 'viral proteins' named entity 'peptides' named entity 'Coxsackie B virus' named entity 'epidemiological' named entity 'lysis' named entity 'Klebsiella pneumoniae' named entity 'autoimmune disease' named entity 'peptide' named entity 'HLA B27' named entity 'experimental autoimmune encephalomyelitis' named entity 'peptides' named entity 'protein products' named entity 'Steve Miller' named entity 'molecular mimicry' named entity 'variety of diseases' named entity 'immune responses' named entity 'John Stuart' named entity 'monoclonal antibodies' named entity 'myelin basic protein' named entity 'Strominger' named entity 'humoral' named entity 'MHC' named entity 'antigenic determinants' named entity 'peptide' named entity 'persistent infections'

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