About: Enhancement of immunostimulatory properties of exosomal vaccines by incorporation of fusion-competent G protein of vesicular stomatitis virus

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About: Enhancement of immunostimulatory properties of exosomal vaccines by incorporation of fusion-competent G protein of vesicular stomatitis virus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Enhancement of immunostimulatory properties of exosomal vaccines by incorporation of fusion-competent G protein of vesicular stomatitis virus
Creator	Nchinda, Godwin Nabi, Ghulam Tenbusch, Matthias Wildner, Oliver Tippler, Bettina Zelenyuk, Maryna Klausüberla, Seraphin Kuate, Temchura, Vladimir
Source	Elsevier; Medline; PMC
abstract	Abstract Exosomes have been proposed as candidates for therapeutic immunization. The present study demonstrates that incorporation of the G protein of vesicular stomatitis virus (VSV-G) into exosome-like vesicles (ELVs) enhances their uptake and induces the maturation of dendritic cells. Targeting of VSV-G and ovalbumin as a model antigen to the same ELVs increased the cross-presentation of ovalbumin via an endosomal acidification mechanism. Immunization of mice with VSV-G and ovalbumin containing ELVs led to an increased IgG2a antibody response, expansion of antigen-specific CD8 T cells, strong in vivo CTL responses, and protection from challenge with ovalbumin expressing tumor cells. Thus, incorporation of VSV-G and targeting of antigens to ELVs are attractive strategies to improve exosomal vaccines.
has issue date	2008-07-04(xsd:dateTime)
bibo:doi	10.1016/j.vaccine.2008.04.069
bibo:pmid	18538453
has license	els-covid
sha1sum (hex)	c568ffb00b959d85bf0e0535c0fb18b08e3e7bf2
schema:url	https://doi.org/10.1016/j.vaccine.2008.04.069
resource representing a document's title	Enhancement of immunostimulatory properties of exosomal vaccines by incorporation of fusion-competent G protein of vesicular stomatitis virus
has PubMed Central identifier	PMC7115564
has PubMed identifier	18538453
schema:publication	Vaccine
resource representing a document's body	covid:c568ffb00b959d85bf0e0535c0fb18b08e3e7bf2#body_text
is schema:about of	named entity 'expressing' named entity 'Exosomes' named entity 'ELVs' named entity 'VESICULAR STOMATITIS VIRUS' named entity 'PROTEIN ' named entity 'FUSION' named entity 'STRONG' named entity 'T CELLS' named entity 'CROSS-PRESENTATION' named entity 'VESICULAR STOMATITIS VIRUS' named entity 'EXOSOMES' named entity 'DENDRITIC CELLS' named entity 'CD8' named entity 'CTL' named entity 'LED' named entity 'PRESENT' named entity 'THERAPEUTIC' named entity 'MATURATION' named entity 'HAVE' named entity 'G PROTEIN' named entity 'MICE' named entity 'CONTAINING' named entity 'ACIDIFICATION' named entity 'RESPONSES' named entity 'UPTAKE' named entity 'G PROTEIN' named entity 'PROTECTION FROM CHALLENGE ' named entity 'INCREASED' named entity 'VACCINES' named entity 'ENHANCEMENT' named entity 'IN VIVO' named entity 'STRATEGIES' named entity 'TUMOR CELLS' named entity 'THEIR' named entity 'ANTIGEN' named entity 'PROTEIN ' named entity 'COMPETENT' named entity 'PROPERTIES' named entity 'IGG2A ANTIBODY' named entity 'ANTIBODY RESPONSE' named entity 'STUDY' named entity 'IMMUNIZATION' named entity 'MECHANISM' named entity 'MODEL' named entity 'VESICLES' named entity 'SPECIFIC' named entity 'VACCINES' named entity 'TARGETING' named entity 'OVALBUMIN' named entity 'LIKE' named entity 'PROPOSED' named entity 'EXPANSION' named entity 'EXOSOME' named entity 'ATTRACTIVE' named entity 'ANTIGENS' named entity 'endosomal' named entity 'ovalbumin' named entity 'antigen' named entity 'phagosomal' named entity 'Sigma-Aldrich' named entity 'fluorescent' named entity 'ELVs' named entity 'OVA' named entity 'cross-presentation' named entity 'mice' named entity 'protein' named entity 'genetic material' named entity 'HSP90' named entity 'IgG2a' named entity 'cytoplasmic domain' named entity 'phenotypic' named entity 'immunogenicity' named entity 'VSV-G'

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