About: Enteroviruses, type 1 diabetes and hygiene: a complex relationship

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Enteroviruses, type 1 diabetes and hygiene: a complex relationship
Creator	Jackson, J Kim, K Drescher, K Kono, K Tracy, S
source	Medline; PMC
abstract	Type 1 diabetes (T1D) is an autoimmune disease in which the immune system mounts an attack on the host's insulin‐producing β cells. Because most cases of T1D cannot be attributed only to individual genetics, it is strongly inferred that there is a significant environmental contribution, such as infection, impacting disease development. The human enteroviruses (HEV) are common picornaviruses often implicated as triggers of human T1D, although precisely which of the numerous HEV may be involved in human T1D development is unknown. Experiments using non‐obese diabetic (NOD) mice, commonly used to model T1D, show that induction of T1D by HEV infection in NOD mice is a multifactorial process involving both the virus and the host. Interestingly, results demonstrate that HEV infection of NOD mice can also induce long‐term protection from T1D under certain conditions, suggesting that a similar mechanism may occur in humans. Based upon both experimental animal and observational human studies, we postulate that HEV have a dual role in T1D development and can either cause or prevent autoimmune disease. Whichever outcome occurs depends upon multiple variables in the host‐virus equation, many of which can be deduced from results obtained from NOD mouse studies. We propose that the background to the sharply rising T1D incidences observed in the 20th century correlates with increased levels of hygiene in human societies. Viewing T1D in this perspective suggests that potential preventative options could be developed. Copyright © 2009 John Wiley & Sons, Ltd.
has issue date	2010-01-04(xsd:dateTime)
bibo:doi	10.1002/rmv.639
bibo:pmid	20049905
has license	no-cc
sha1sum (hex)	c5626fa53c4443c96cd592e3020d37c99ba54cf2
schema:url	https://doi.org/10.1002/rmv.639
resource representing a document's title	Enteroviruses, type 1 diabetes and hygiene: a complex relationship
has PubMed Central identifier	PMC7169204
has PubMed identifier	20049905
schema:publication	Rev Med Virol
resource representing a document's body	covid:c5626fa53c4443c96cd592e3020d37c99ba54cf2#body_text
is schema:about of	named entity 'HEV' named entity 'postulate' named entity 'development' named entity 'multiple' named entity 'T1D' named entity 'induce' named entity 'rising' named entity 'hygiene' named entity 'T1D' named entity 'commonly' named entity 'century' named entity 'mechanism' named entity 'humans' named entity 'host' named entity 'enteroviruses' named entity 'infection' named entity 'impacting' named entity 'development' named entity 'prevent' named entity 'diabetic' named entity 'T1D' named entity 'host' named entity 'human' named entity 'cases' named entity 'Because' named entity 'NOD mice' named entity 'HEV' named entity 'picornaviruses' named entity 'T1D' named entity 'NOD mice' named entity 'NOD mouse' named entity 'human studies' named entity 'autoimmune disease' named entity 'virus' named entity 'Type 1 diabetes' named entity 'type 1 diabetes' named entity 'complex relationship' named entity 'attack' named entity 'viruses' named entity 'insulitis' named entity 'NOD mice' named entity 'sequence space' named entity 'T1D' named entity 'virus' named entity 'insulitis' named entity 'aetiology' named entity 'pancreatic islets' named entity 'Enteroviral' named entity 'T1D' named entity 'Tregs' named entity 'T1D' named entity 'nucleotide' named entity 'T1D' named entity 'T1D' named entity 'virus' named entity 'IFIH1' named entity 'epidemic' named entity 'T1D' named entity 'T1D' named entity 'poor hygiene' named entity 'T1D' named entity 'insulitis' named entity 'infection' named entity 'ENTEROVIRUSES' named entity 'virus replication' named entity 'NOD mice' named entity 'T1D' named entity 'polioviruses' named entity 'NOD mouse' named entity 'T1D' named entity 'diabetic' named entity 'NOD mice' named entity 'developed countries' named entity 'T1D' named entity 'IFIH1' named entity 'inoculation' named entity 'T1D'

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