About: An outbreak of acute respiratory disease caused by a virus associated RNA II gene mutation strain of human adenovirus 7 in China, 2015

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About: An outbreak of acute respiratory disease caused by a virus associated RNA II gene mutation strain of human adenovirus 7 in China, 2015 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	An outbreak of acute respiratory disease caused by a virus associated RNA II gene mutation strain of human adenovirus 7 in China, 2015
Creator	Li, Peng Li, Hao Xie, Jing Liu, Hongbo Du, Xinying Jia, Leili Liang, Beibei Ma, Qiuxia Qiu, Shaofu Sheng, Chunyu Song, Hongbin Wang, Ligui Wang, Qiongshu Wu, Fuli Yang, Chaojie Yang, Xiaoxia
Source	Medline; PMC
abstract	Human adenovirus 7 (HAdV-7) strains are a major cause of acute respiratory disease (ARD) among adults and children, associated with fatal pneumonia. An ARD outbreak caused by HAdV-7 that involved 739 college students was reported in this article. To better understand the underlying cause of this large-scale epidemic, virus strains were isolated from infected patients and sequence variations of the whole genome sequence were detected. Evolutionary trees and alignment results indicated that the major capsid protein genes hexon and fibre were strongly conserved among serotype 7 strains in China at that time. Instead, the HAdV-7 strains presented three thymine deletions in the virus associated RNA (VA RNA) II terminal region. We also found that the mutation might lead to increased mRNA expression of an adjacent gene, L1 52/55K, and thus promoted faster growth. These findings suggest that sequence variation of VA RNA II gene was a potential cause of such a severe HAdV-7 infection and this gene should be a new-emerging factor to be monitored for better understanding of HAdV-7 infection.
has issue date	2017-02-22(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0172519
bibo:pmid	28225804
has license	cc-by
sha1sum (hex)	c53d3d043454289602f4177bb5125ef3d9d0df38
schema:url	https://doi.org/10.1371/journal.pone.0172519
resource representing a document's title	An outbreak of acute respiratory disease caused by a virus associated RNA II gene mutation strain of human adenovirus 7 in China, 2015
has PubMed Central identifier	PMC5321423
has PubMed identifier	28225804
schema:publication	PLoS One
resource representing a document's body	covid:c53d3d043454289602f4177bb5125ef3d9d0df38#body_text
is schema:about of	named entity 'STRAIN' named entity 'VIRUS ASSOCIATED' named entity 'fibre' named entity 'strains' named entity 'time' named entity 'virus' named entity 'RNA' named entity 'adults' named entity 'capsid' named entity 'gene' named entity 'respiratory disease' named entity 'serotype' named entity 'caused' named entity 'CHINA' named entity 'EPIDEMIC' named entity 'VIRUS ASSOCIATED' named entity 'ISOLATED' named entity 'ADJACENT' named entity 'ADULTS' named entity 'FATAL' named entity 'FACTOR' named entity 'ARTICLE' named entity 'WAS A' named entity 'SEROTYPE' named entity 'STRAINS' named entity 'UNDERLYING' named entity 'HEXON' named entity 'INDICATED' named entity 'GENES' named entity 'FOUND' named entity 'POTENTIAL' named entity 'CHILDREN' named entity 'HUMAN ADENOVIRUS 7' named entity 'RNA II' named entity 'OUTBREAK' named entity 'MONITORED' named entity 'LARGE' named entity 'II GENE MUTATION' named entity '2015' named entity 'CAUSED BY' named entity 'FASTER GROWTH' named entity 'VA RNA' named entity 'RNA' named entity 'INCREASED' named entity 'SUGGEST' named entity 'CAUSE' named entity 'DETECTED' named entity 'SEQUENCE VARIATION' named entity 'CHINA' named entity 'PRESENTED' named entity 'REGION' named entity 'WHOLE GENOME' named entity 'GENOME SEQUENCE' named entity 'MRNA EXPRESSION' named entity 'A MAJOR' named entity 'OUTBREAK' named entity 'VIRUS' named entity 'RNA II' named entity 'PROTEIN ' named entity 'THYMINE' named entity 'PNEUMONIA' named entity 'INFECTED' named entity 'SCALE' named entity 'RESULTS' named entity 'LEAD' named entity 'TREES'

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