About: Macromolecular Antiviral Agents against Zika, Ebola, SARS, and Other Pathogenic Viruses

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About: Macromolecular Antiviral Agents against Zika, Ebola, SARS, and Other Pathogenic Viruses Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Macromolecular Antiviral Agents against Zika, Ebola, SARS, and Other Pathogenic Viruses
Creator	Münch, Jan Röcker, Annika Harms, Mirja Gajda, Paulina Tolstrup, Martin Zuwala, Kaja Müller, Janis Riber, Camilla Zelikin, Alexander Andersen, Anna Løvschall, Kaja Kreppel, Florian Schandock, Franziska
Source	Medline; PMC
abstract	Viral pathogens continue to constitute a heavy burden on healthcare and socioeconomic systems. Efforts to create antiviral drugs repeatedly lag behind the advent of pathogens and growing understanding is that broad‐spectrum antiviral agents will make strongest impact in future antiviral efforts. This work performs selection of synthetic polymers as novel broadly active agents and demonstrates activity of these polymers against Zika, Ebola, Lassa, Lyssa, Rabies, Marburg, Ebola, influenza, herpes simplex, and human immunodeficiency viruses. Results presented herein offer structure–activity relationships for these pathogens in terms of their susceptibility to inhibition by polymers, and for polymers in terms of their anionic charge and hydrophobicity that make up broad‐spectrum antiviral agents. The identified leads cannot be predicted based on prior data on polymer‐based antivirals and represent promising candidates for further development as preventive microbicides.
has issue date	2017-09-25(xsd:dateTime)
bibo:doi	10.1002/adhm.201700748
bibo:pmid	28945945
has license	no-cc
sha1sum (hex)	c537da32af948fc117eeb863f40ceb8db93c8b87
schema:url	https://doi.org/10.1002/adhm.201700748
resource representing a document's title	Macromolecular Antiviral Agents against Zika, Ebola, SARS, and Other Pathogenic Viruses
has PubMed Central identifier	PMC7161897
has PubMed identifier	28945945
schema:publication	Adv Healthc Mater
resource representing a document's body	covid:c537da32af948fc117eeb863f40ceb8db93c8b87#body_text
is schema:about of	named entity 'Viruses' named entity 'Other' named entity 'Antiviral Agents' named entity 'Pathogenic Viruses' named entity 'HIV-1' named entity 'LTR' named entity 'viruses' named entity 'virus' named entity 'HIV-1' named entity 'LTR' named entity 'anionic' named entity 'firefly luciferase' named entity 'infection' named entity 'polyanions' named entity 'infection' named entity 'Ebola' named entity 'polysaccharides' named entity 'polymers' named entity 'Mammalian Cells' named entity 'SARS' named entity 'ZIKV' named entity 'antiviral effect' named entity 'small molecule drug' named entity 'polyanion' named entity 'macromolecules' named entity 'infection' named entity 'TMB' named entity 'plasmids' named entity 'lipid bilayer' named entity 'HSV-2' named entity 'HIV-1 infection' named entity 'polymers' named entity 'virus' named entity 'antiviral activity' named entity 'hemorrhagic fevers' named entity 'ZIKV' named entity 'ZIKV' named entity 'size-exclusion chromatography' named entity 'polymers' named entity 'Sigma-Aldrich' named entity 'Ebola' named entity 'env gene' named entity 'polymers' named entity 'flow cytometer' named entity 'polymers' named entity 'inoculate' named entity 'polymers' named entity 'glutamine' named entity 'supernatant' named entity 'cell line' named entity 'CXCR4' named entity 'polymers' named entity 'virus' named entity 'SARS epidemic' named entity 'viral pathogens' named entity 'polymer' named entity 'infection' named entity 'Glostrup' named entity 'monomers' named entity 'infection' named entity 'Marburg' named entity 'ZIKV' named entity 'antiviral activity' named entity 'Reporter Gene Assay' named entity 'Live cells' named entity 'ZIKV' named entity 'dispersity' named entity '0.01' named entity 'BSA'

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