About: Quantitative Analysis of Cellular Proteome Alterations in CDV-Infected Mink Lung Epithelial Cells

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About: Quantitative Analysis of Cellular Proteome Alterations in CDV-Infected Mink Lung Epithelial Cells Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Quantitative Analysis of Cellular Proteome Alterations in CDV-Infected Mink Lung Epithelial Cells
Creator	Cao, Zhigang Cheng, Shipeng Cheng, Yuening Li, Shuang Lin, Peng Sun, Yaru Tong, Mingwei Wang, Jianke Yi, Li Li, J Sun, Na Adachi, Akio Sarute, Nicolas Cheng, Sun Wang, Cao
Source	PMC
abstract	Canine distemper virus (CDV), a paramyxovirus, causes a severe highly contagious lethal disease in carnivores, such as mink. Mink lung epithelial cells (Mv.1.Lu cells) are sensitive to CDV infection and are homologous to the natural host system of mink. The current study analyzed the response of Mv.1.Lu cells to CDV infection by iTRAQ combined with LC–MS/MS. In total, 151 and 369 differentially expressed proteins (DEPs) were markedly up-regulated or down-regulated, respectively. Thirteen DEPs were validated via real-time RT-PCR or western blot analysis. Network and KEGG pathway analyses revealed several regulated proteins associated with the NF-κB signaling pathway. Further validation was performed by western blot analysis and immunofluorescence assay, which demonstrated that different CDV strains induced NF-κB P65 phosphorylation and nuclear translocation. Moreover, the results provided interesting information that some identified DEPs possibly associated with the pathogenesis and the immune response upon CDV infection. This study is the first overview of the responses to CDV infection in Mv.1.Lu cells, and the findings will help to analyze further aspects of the molecular mechanisms involved in viral pathogenesis and the immune responses upon CDV infection.
has issue date	2017-12-22(xsd:dateTime)
bibo:doi	10.3389/fmicb.2017.02564
bibo:pmid	29312244
has license	cc-by
sha1sum (hex)	c5157f9976942d166a600cb570a5a8fa9ab91e57
schema:url	https://doi.org/10.3389/fmicb.2017.02564
resource representing a document's title	Quantitative Analysis of Cellular Proteome Alterations in CDV-Infected Mink Lung Epithelial Cells
has PubMed Central identifier	PMC5743685
has PubMed identifier	29312244
schema:publication	Front Microbiol
resource representing a document's body	covid:c5157f9976942d166a600cb570a5a8fa9ab91e57#body_text
is schema:about of	named entity 'INFECTED' named entity 'QUANTITATIVE ANALYSIS' named entity 'MINK' named entity 'MOLECULAR' named entity 'SIGNALING PATHWAY' named entity 'CDV' named entity 'DEMONSTRATED' named entity 'OVERVIEW' named entity 'IMMUNE RESPONSE' named entity 'CARNIVORES' named entity 'PROVIDED' named entity 'CDV' named entity 'CANINE DISTEMPER VIRUS' named entity 'DIFFERENT' named entity 'NETWORK' named entity 'PERFORMED BY' named entity 'NUCLEAR TRANSLOCATION' named entity 'PARAMYXOVIRUS' named entity 'DOWN-REGULATED' named entity 'REAL-TIME RT-PCR' named entity 'MECHANISMS' named entity 'PATHWAY' named entity 'CAUSES' named entity 'MARKEDLY' named entity 'REGULATED' named entity 'VALIDATION' named entity 'TOTAL' named entity 'RESPONSES' named entity 'COMBINED' named entity 'THIRTEEN' named entity 'ALTERATIONS' named entity 'CELLULAR' named entity 'INFECTION' named entity 'BAB' named entity 'ITRAQ' named entity 'DISEASE' named entity 'HELP' named entity 'SEVERE' named entity 'NATURAL' named entity 'ANALYZED' named entity 'LUNG' named entity 'FINDINGS' named entity 'POSSIBLY' named entity 'HIGHLY' named entity 'EXPRESSED' named entity 'RESPONSE' named entity 'CELLS' named entity 'CURRENT' named entity 'LC-MS' named entity 'ASSOCIATED WITH' named entity 'UP-REGULATED' named entity 'EPITHELIAL CELLS' named entity 'INTERESTING' named entity 'IDENTIFIED' named entity 'IMMUNOFLUORESCENCE ASSAY' named entity 'MINK' named entity 'DEPS' named entity 'SYSTEM' named entity 'KEGG' named entity 'P65' named entity 'RESULTS' named entity 'LETHAL' named entity 'SENSITIVE TO' named entity 'INDUCED' named entity 'STUDY' named entity 'REVEALED' named entity 'PATHOGENESIS'

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