About: IL-13 is associated with reduced illness and replication in primary respiratory syncytial virus infection in the mouse

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About: IL-13 is associated with reduced illness and replication in primary respiratory syncytial virus infection in the mouse Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	IL-13 is associated with reduced illness and replication in primary respiratory syncytial virus infection in the mouse
Creator	Graham, Barney Moore, Martin Stokes, R Chiappetta, Constance Colasurdo, Giuseppe Durbin, Joan Elias, Jack Goleniewska, Kasia Hashimoto, Koichi O'neal, Jamye Rutigliano, John Zhou, Weisong Zhu, Zhou
source	Elsevier; Medline; PMC
abstract	The role of IL-13 in respiratory syncytial virus (RSV) immunopathogenesis is incompletely described. To assess the effect of IL-13 on primary RSV infection, transgenic mice which either overexpress IL-13 in the lung (IL-13 OE) or nontransgenic littermates (IL-13 NT) were challenged intranasally with RSV. IL-13 OE mice had significantly decreased peak viral titers four days after infection compared to non-transgenic littermates. In addition, the IL-13 OE mice had significantly lower RSV-induced weight loss and reduced lung IFN-γ protein expression compared with IL-13 NT mice. In contrast, primary RSV challenge of IL-13 deficient mice resulted in a small, but statistically significant increase in viral titers on day four after infection, no difference in RSV-induced weight loss compared to wild type mice, and augmented IFN-γ production on day 6 after infection. In STAT1-deficient (STAT1 KO) mice, where primary RSV challenge produced high levels of IL-13 production in the lungs, treatment with an IL-13 neutralizing protein resulted in greater peak viral titers both four and six days after RSV and greater RSV-induced weight loss compared to mice treated with a control protein. These results suggest that IL-13 modulates illness from RSV-infection.
has issue date	2006-11-01(xsd:dateTime)
bibo:doi	10.1016/j.micinf.2006.09.007
bibo:pmid	17110149
has license	green-oa
sha1sum (hex)	c4f21e922fbb2aeeb74b3ea72ef2073fdbb41f48
schema:url	https://doi.org/10.1016/j.micinf.2006.09.007
resource representing a document's title	IL-13 is associated with reduced illness and replication in primary respiratory syncytial virus infection in the mouse
has PubMed Central identifier	PMC1811125
has PubMed identifier	17110149
schema:publication	Microbes and Infection
resource representing a document's body	covid:c4f21e922fbb2aeeb74b3ea72ef2073fdbb41f48#body_text
is schema:about of	named entity 'RSV' named entity 'viral' named entity 'IL-13' named entity 'protein' named entity 'IL-13' covid:arg/c4f21e922fbb2aeeb74b3ea72ef2073fdbb41f48 named entity 'IL-13' named entity 'neutralizing' named entity 'RSV' named entity 'IL-13' named entity 'RSV' named entity 'IL-13' named entity 'infection' named entity 'infection' named entity 'mice' named entity 'IL-13' named entity 'protein expression' named entity 'viral titers' named entity 'RSV' named entity 'transgenic' named entity 'RSV' named entity 'protein' named entity 'lung' named entity 'viral titers' named entity 'overexpress' named entity 'IL-13' named entity 'IL-13' named entity 'IL-13' named entity 'production' named entity 'protein' named entity 'bronchoalveolar lavage fluid' named entity 'Minneapolis' named entity 'RSV' named entity 'RSV infection' named entity 'mice' named entity 'IL-13' named entity 'IL-4 receptor' named entity 'IL-13' named entity 'serum' named entity 'IL-13' named entity 'RSV' named entity 'viral titers' named entity 'RSV' named entity 'IL-13' named entity 'supernatants' named entity 'KO mice' named entity 'mucus production' named entity 'lungs' named entity 'IFN-g' named entity 'RSV' named entity 'RSV' named entity 'STAT1' named entity 'IL-13' named entity 'mice' named entity 'BALB' named entity 'negative control' named entity 'antibodies' named entity 'intracellular' named entity 'immunoglobulin G1' named entity 'CTL' named entity 'IFN-g' named entity 'IL-13' named entity 'Tween 20' named entity 'IL-13' named entity 'cathepsins' named entity 'mice' named entity 'supernatants' named entity 'transgenic' named entity 'IL-13'

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