About: Panther Fusion® Respiratory Virus Assays for the detection of influenza and other respiratory viruses()

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About: Panther Fusion® Respiratory Virus Assays for the detection of influenza and other respiratory viruses() Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Panther Fusion® Respiratory Virus Assays for the detection of influenza and other respiratory viruses()
Creator	Stellrecht, Kathleen Butt, Shafiq Cimino, Jesse Maceira, Vincente Wilson, Lisa
topic	covid:c4cb5f051397c82c13605b8f3739e60f5adfcd37#this
Source	Elsevier; Medline; PMC
abstract	BACKGROUND: Nucleic acid amplification tests (NAATs), such as PCR, are preferred for respiratory virus testing, due to superior diagnostic accuracy and faster turnaround time. Panther Fusion® Respiratory Assays (Fusion), which includes FluA/B/RSV (FFABR), Paraflu and AdV/hMPV/RV, offers a modular approach to syndromic testing on a fully automated platform while improving gene targets and expanding the test menu. OBJECTIVES AND STUDY DESIGN: We evaluated Fusion using 275 consecutive nasopharyngeal specimens previously used in an analysis of five PCRs, as well as 225 archived specimens. RESULTS: Of the combined 500 specimens, 134 were positive for influenza A (FluA), 54 for FluB, 65 for RSV, 64 for parainfluenza (PIV), 24 for adenovirus (AdV), 21 for humanmetapneumovirus (hMPV), and 40 for rhinovirus (RV) with Fusion. Of the positive samples Fusion correlated with historical results for all but one, despite multiple freeze-thaws cycles of this collection. Fusion was positive for an additional 33 samples, including 11 FluAs, 7 RSVs, 3 PIV3s, 3 AdV, 6 hMPV and 3 RVs. These samples were retested with corresponding Prodesse (Pro) assays using quadruple sample volume. This resolver test confirmed Fusion results for an additional 4 FluAs, 4 RSVs, 1 PIV3 and 3 AdVs. The sensitivity and specificity ranges of Fusion were 99–100% and 98–100%. Limit of detection (LOD) analyses were performed on a variety of Flu isolates. The LODs ranged from 2.69 to 2.99 log copies/ml and demonstrated superior LOD as compared to previously published data for some assays or to concurrent analyses with two new commercial tests.
has issue date	2019-11-09(xsd:dateTime)
bibo:doi	10.1016/j.jcv.2019.104204
bibo:pmid	31743836
has license	no-cc
sha1sum (hex)	c4cb5f051397c82c13605b8f3739e60f5adfcd37
schema:url	https://doi.org/10.1016/j.jcv.2019.104204
resource representing a document's title	Panther Fusion® Respiratory Virus Assays for the detection of influenza and other respiratory viruses()
has PubMed Central identifier	PMC7172166
has PubMed identifier	31743836
schema:publication	J Clin Virol
resource representing a document's body	covid:c4cb5f051397c82c13605b8f3739e60f5adfcd37#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/c4cb5f051397c82c13605b8f3739e60f5adfcd37
is schema:about of	named entity 'log' named entity 'analyses' named entity 'sensitivity' named entity 'Fusion' named entity 'positive' named entity 'Panther' named entity 'Respiratory' named entity 'tests' named entity 'samples' named entity 'menu' named entity 'specimens' named entity 'test' named entity 'Panther' named entity 'isolates' named entity 'combined' named entity 'Background' named entity 'virus' named entity 'samples' named entity 'Virus' named entity 'AdV' named entity 'rhinovirus' named entity 'influenza' named entity 'AdV' named entity 'adenovirus' named entity 'virus' named entity 'AdV' named entity 'HIV' named entity 'viruses' named entity 'serially diluted' named entity 'AdV' named entity 'viral strain' named entity 'gene' named entity 'virus' named entity 'nucleocapsid' named entity 'Hologic' named entity 'Quidel' named entity 'hexon' named entity 'BioMerieux' named entity 'SPSS' named entity 'subtyping' named entity 'Hologic' named entity 'Influenza' named entity 'genomic drift' named entity 'virus' named entity 'NAATs' named entity 'package insert' named entity 'Respiratory tract infections' named entity 'influenza' named entity 'Hologic' named entity 'genotypes' named entity 'Sanger sequencing' named entity 'sensitivity and specificity' named entity 'viruses' named entity 'Hologic' named entity 'viruses' named entity 'A/B test' named entity 'gene' named entity 'sensitivities and specificities' named entity 'pediatric' named entity 'Hologic' named entity 'influenza' named entity 'gene' named entity 'influenza' named entity 'genotyping' named entity 'Carlsbad, CA' named entity 'Food and Drug Administration' named entity 'LODs' named entity 'viruses' named entity 'PCR' named entity 'test sensitivity' named entity 'true positive' named entity 'serially diluted' named entity 'RP.' named entity 'genetic drift' named entity 'false negative'

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